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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Celastrus orbiculatus
Vigne invasif d'Amérique du Nord utilisée en médecine traditionnelle chinoise pour les arthralgies et le cancer.
Celastrus orbiculatus, an invasive Asian vine naturalized in North America, is used in traditional Chinese and Korean medicine primarily for arthritis and cancer. Its key active compound, celastrol, has demonstrated potent anti-inflammatory and anticancer properties in preclinical studies, while wilforic acid, flavonoids, and alkaloids contribute to its pharmacological profile. The herb is also being investigated for neuroprotective effects.
Celastrol, a triterpenoid quinone methide, inhibits the NF-κB pathway by targeting IKK complex, thereby reducing pro-inflammatory cytokine production. It also activates the Nrf2/ARE pathway, enhancing antioxidant defenses. Additionally, celastrol induces apoptosis in cancer cells via mitochondrial dysfunction and caspase activation, and modulates the proteasome and heat shock response. Flavonoids and alkaloids may contribute to anti-inflammatory and neuroprotective effects through inhibition of COX-2 and iNOS.
Vigne invasif d'Amérique du Nord utilisée en médecine traditionnelle chinoise pour les arthralgies et le cancer.
Celastrus orbiculatus, an invasive Asian vine naturalized in North America, is used in traditional Chinese and Korean medicine primarily for arthritis and cancer. Its key active compound, celastrol, has demonstrated potent anti-inflammatory and anticancer properties in preclinical studies, while wilforic acid, flavonoids, and alkaloids contribute to its pharmacological profile. The herb is also being investigated for neuroprotective effects.
Celastrol, a triterpenoid quinone methide, inhibits the NF-κB pathway by targeting IKK complex, thereby reducing pro-inflammatory cytokine production. It also activates the Nrf2/ARE pathway, enhancing antioxidant defenses. Additionally, celastrol induces apoptosis in cancer cells via mitochondrial dysfunction and caspase activation, and modulates the proteasome and heat shock response. Flavonoids and alkaloids may contribute to anti-inflammatory and neuroprotective effects through inhibition of COX-2 and iNOS.