Cinquefoil (Potentilla reptans): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Cinquefoil work as an astringent?

Cinquefoil root contains high concentrations of tannins and ellagitannins, which are polyphenolic compounds responsible for its astringent activity. When applied topically or ingested, these compounds bind to proteins in mucous membranes or wound surfaces, creating a protective layer that reduces secretions and promotes tissue tightening. This mechanism explains its traditional use for treating diarrhea and wound healing. Evidence Level: C/Traditional.

Does Cinquefoil interact with any medications?

Due to its significant tannin content, Cinquefoil may interfere with the absorption of certain oral medications if taken simultaneously. Tannins can bind to alkaloids and other drug compounds in the digestive tract, potentially reducing their effectiveness. It is recommended to separate the intake of Cinquefoil preparations from prescription medications by at least two hours to avoid absorption issues. Evidence Level: Theoretical.

What is the recommended dosage for Cinquefoil root?

For adults, the standard traditional dosage involves consuming 2 to 3 grams of the dried root prepared as a decoction, or taking 2 to 3 mL of tincture daily. For external application, the root can be made into a poultice for wound care. Dosage information is based on traditional use rather than clinical trials. Evidence Level: Traditional.

Is Cinquefoil safe to use during pregnancy?

Cinquefoil is considered unsafe during pregnancy, particularly in large oral doses. The herb's strong astringent properties and uterine stimulation potential pose risks to the pregnancy. Additionally, the tannins may cause constipation, which is often already a concern for pregnant women. Pregnant individuals should avoid internal use of this herb and consult a healthcare provider before considering topical applications. Evidence Level: C/Traditional.

Can Cinquefoil help treat diarrhea?

Yes, European folk medicine traditions have long used Cinquefoil root to manage diarrhea. The herb's high tannin content acts as an intestinal astringent, helping to reduce fluid loss and tighten intestinal tissues. While this use is well-documented in ethnobotanical texts, robust clinical trials confirming its efficacy are lacking, so it should not replace standard medical treatments for severe conditions. Evidence Level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Potentilla reptans is a medicinal herb with demonstrated antioxidant, anti-inflammatory, and cardioprotective properties in animal and in silico models [PMID:25850209, 33866888, 34823510].

Contexte

Potentilla reptans L., also known as silverweed cinquefoil, is a plant of the Rosaceae family [PMID:24147362, 34288682].

Usages traditionnels

Traditionally, it has been used as an anti-inflammatory and anti-infective agent [PMID:24147362]. In western areas of China, specifically in the Tibet Autonomous Region and Gansu and Qinghai Provinces, the roots are used as dietary supplements, foods, and medicines [PMID:34288682].

Composés actifs

Active compounds isolated from the root include six new triterpenoids (tormentic acid ester glucosides derivatives, 3-oxoursane ester glycoside, and 11-methoxy-ursane ester glycosides), catechin [PMID:33866888], and pentacyclic triterpenoid saponins known as poterinasides A-J [PMID:34288682]. Other identified components include chlorogenic acid [PMID:39648840].

Mécanisme d'action

The herb may exert cardioprotective effects by inhibiting GSK-3β and SGK1 protein kinases [PMID:33866888] and by activating the Nrf2 pathway and scavenging reactive oxygen species (ROS) [PMID:30419282]. It may also protect cardiomyocytes by regulating lncRNAs H19 and MIAT [PMID:37525174] and acting via RISK/SAFE pathways [PMID:34823510].

Preuves cliniques

Preuve DInflammation

Rhizome aqueous extract showed a maximum anti-inflammatory effect of 61.37% in a mice ear edema model [PMID:25850209].

Preuve DMyocardial Ischemia/Reperfusion Injury

Root extracts demonstrated cardioprotective and anti-apoptotic effects in isolated rat hearts [PMID:30419282, 34823510] and enhanced H9C2 myoblast viability [PMID:37525174].

Preuve DBrain Ischemia/Reperfusion

Root extract was investigated for neuroprotective, antioxidative, anti-inflammatory, and antiapoptotic effects in a rat brain model [PMID:37642540].

Preuve DBreast Cancer (4T1 cell line)

Aqueous extracts of rhizome and aerial parts showed concentration-dependent cytotoxic effects (IC50: 280.51 and 310.79 μg/mL respectively) [PMID:24147362].

Preuve DProtozoan infections

Extracts showed antiprotozoal activity against Tetrahymena pyriformis [PMID:36786997].

Synthèse des preuves

The current evidence is based on in vitro studies, in silico molecular docking, and animal models (rats/mice); there are no human clinical trials provided.

Sources PubMed

1.PMID: 33866888 (2022) — Six new triterpenoids from the root of Potentilla reptans and their cardioprotective effects in silico. · Natural product research
2.PMID: 37642540 (2023) — Neuroprotective effect of Potentilla reptans L. root in the rat brain global ischemia/reperfusion model. · Archiv der Pharmazie
3.PMID: 34823510 (2021) — Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart. · BMC complementary medicine and therapies
4.PMID: 36786997 (2022) — New Plant Species Showing Antiprotozoian Activity. · Doklady. Biochemistry and biophysics
5.PMID: 24147362 (2013) — Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts. · Acta poloniae pharmaceutica

Cinquefoil

Sources et citations

Calculer une dose sûre de Cinquefoil

Callistemon citrinus

Bistort Root

Cranesbill Geranium

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Cinquefoil

Sources et citations

Calculer une dose sûre de Cinquefoil

Plantes associées

Callistemon citrinus

Bistort Root

Cranesbill Geranium

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales