Cleome Gynandra (Cleome gynandra): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Cleome gynandra work as a pain reliever?

Cleome gynandra contains glucosinolates and flavonoids that exhibit anti-inflammatory and analgesic properties. These compounds appear to inhibit inflammatory pathways and may modulate pain signaling. The plant's alkaloids and saponins contribute additional therapeutic effects. Research suggests the anti-inflammatory action occurs through suppression of pro-inflammatory mediators, though the exact molecular mechanisms require further investigation (Evidence Level C, preliminary studies).

Does Cleome gynandra interact with any medications?

There are no well-documented drug interactions for Cleome gynandra in current scientific literature. However, due to its potential effects on inflammation, caution is advised when taking anti-inflammatory medications. The glucosinolate content may theoretically affect thyroid function, so individuals on thyroid medications should consult a healthcare provider before use. Always inform your doctor about herbal supplements you are taking.

What is the recommended dosage for Cleome gynandra?

For adults, the typical dosage is fresh leaves consumed as a vegetable in normal dietary amounts, or 5-10 grams of dried leaves prepared as tea daily. Traditional use involves incorporating the leaves into soups and stews. Standardized extracts are not widely available, so dosing relies primarily on traditional preparation methods. Consult a qualified herbalist for personalized recommendations (Evidence Level C, Traditional use).

Is Cleome gynandra safe to take during pregnancy?

Cleome gynandra is generally considered safe when consumed in normal dietary amounts during pregnancy, as it is traditionally eaten as a vegetable across sub-Saharan Africa. However, high doses or concentrated preparations should be avoided due to insufficient safety data. Women who are pregnant or breastfeeding should stick to food-level consumption. Those with allergies to plants in the Cleomaceae family should avoid this herb entirely.

What is Cleome gynandra used for in traditional medicine?

Cleome gynandra has been used traditionally across sub-Saharan Africa and Asia for treating headaches, fever, wounds, respiratory infections, and digestive disorders. The leaves are commonly prepared as decoctions, teas, or incorporated into foods. These traditional applications are supported by the plant's glucosinolate, flavonoid, and alkaloid content, though clinical evidence remains limited (Evidence Level C, Traditional use).

What side effects can Cleome gynandra cause?

Cleome gynandra is generally well-tolerated when consumed in food amounts. Reported side effects are typically mild and may include digestive upset such as nausea or stomach discomfort, particularly when consumed in large quantities. Some individuals may experience allergic reactions, especially those sensitive to plants in the Cleomaceae family. Discontinue use if adverse reactions occur and consult a healthcare provider.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 29 articles PubMed · modèle : gemma4:31b

Résumé

Cleome gynandra, also known as the spider plant, is a nutrient-dense, climate-resilient indigenous leafy vegetable predominantly used in Africa [PMID:36212376, PMID:37662144]. It is valued for its nutritional and medicinal properties, serving as a resource to combat malnutrition [PMID:36119621, PMID:40972038].

Contexte

Cleome gynandra (also referred to as Gynandropsis gynandra) is an erect annual herb that can grow up to 150 cm tall, characterized by a long taproot and strong branching [PMID:36212376]. It is a drought-tolerant plant utilizing a C4 carbon fixation pathway [PMID:37662144, PMID:22289126].

Usages traditionnels

It is used as a traditional leafy vegetable throughout Africa [PMID:36212376] and is used in Uganda topically for presumed antifungal activity against Tinea capitis [PMID:27391957]. In India, it is traditionally used for the treatment of tumors and inflammatory conditions [PMID:20307641].

Composés actifs

The plant contains vitamins, minerals, proteins, and secondary metabolites [PMID:36119621, PMID:36212376]. Specific identified compounds include flavonoids, terpene glycosides, glucosinolates, phenolic compounds (specifically rutin and astragalin), and a novel dammarane triterpenoid called cleogynol [PMID:32771676, PMID:34943055, PMID:10217723]. It is rich in potassium, calcium, magnesium, phosphorus, iron, manganese, zinc, and ascorbic acid [PMID:28873690, PMID:29354633].

Mécanisme d'action

The plant exhibits free radical scavenging activity and can suppress the levels of lysosomal enzymes and protein-bound carbohydrates in arthritic models [PMID:16132687, PMID:17276570].

Preuves cliniques

Preuve DTinea capitis

In vitro evaluation showed antifungal activity; ethanol extracts had MICs ranging from 0.0313 to 0.5 mg/ml depending on the strain [PMID:27391957]

Preuve DAdjuvant-induced arthritis (rat model)

Oral administration of leaf extract (150 mg/kg) significantly decreased paw edema and restored hematological and biochemical parameters to near normal [PMID:15857216, PMID:17276570]

Preuve DEhrlich's Ascites Carcinoma (mice model)

Methanol extract (200 and 400 mg/kg) showed a significant decrease in tumor volume [PMID:20307641]

Synthèse des preuves

The current evidence consists primarily of in vitro studies and animal models (rats and mice) as well as botanical reviews. There are no human clinical trials provided in the source material.

Sources PubMed

1.PMID: 36212376 (2022) — Cleome gynandra: A wonder climate-smart plant for nutritional security for millions in semi-arid areas. · Frontiers in plant science
2.PMID: 38446931 (2022) — Nutritional, phytochemical and diverse health-promoting qualities of Cleome gynandra. · Critical reviews in food science and nutrition
3.PMID: 36119621 (2022) — Leaf elemental composition analysis in spider plant [Gynandropsis gynandra L. (Briq.)] differentiates three nutritional groups. · Frontiers in plant science
4.PMID: 40972038 (2026) — Spinning together agricultural and evo-devo research for Gynandropsis gynandra (spider plant). · Annals of botany
5.PMID: 22289126 (2012) — The dicotyledonous NAD malic enzyme C4 plant Cleome gynandra displays age-dependent plasticity of C4 decarboxylation biochemistry.

Cleome Gynandra

Sources et citations

Calculer une dose sûre de Cleome Gynandra

Phlomis fruticosa

Lavandula latifolia

Calamintha nepeta

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Cleome Gynandra

Sources et citations

Calculer une dose sûre de Cleome Gynandra

Plantes associées

Phlomis fruticosa

Lavandula latifolia

Calamintha nepeta

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales