Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 22 articles PubMed · modèle : gemma4:31b
Résumé
Contexte
Usages traditionnels
Composés actifs
Mécanisme d'action
Preuves cliniques
Ethanolic extract and ultra-highly diluted Condurango 30C showed ameliorating effects on benzo[a]pyrene-induced lung cancer in rats via caspase-3-mediated apoptosis [PMID:25780671, PMID:25780694].
In vitro studies show that Condurango extract and condurangogenin A induce ROS-dependent apoptosis and cell-cycle arrest [PMID:23807740, PMID:26389000].
In vitro studies suggest Gonolobus condurango may act as a histone deacetylase inhibitor (HDACi) in TNBC cell lines [PMID:40375313].
Pregnane glycosides from condurango cortex acted as differentiation inducers, transforming M1 cells into phagocytic cells [PMID:8004709].
Synthèse des preuves
Sources PubMed
- 1.PMID: 40375313 (2025) — Exploring the potential of Gonolobus condurango as a histone deacetylase inhibitor in triple-negative breast cancer cell lines: in vitro study. · BMC complementary medicine and therapies
- 2.PMID: 26389000 (2015) — Condurango (Gonolobus condurango) Extract Activates Fas Receptor and Depolarizes Mitochondrial Membrane Potential to Induce ROS-dependent Apoptosis in Cancer Cells in vitro: CE-treatment on HeLa: a ROS-dependent mechanism. · Journal of pharmacopuncture
- 3.PMID: 25780677 (2013) — Evidence of an Epigenetic Modification in Cell-cycle Arrest Caused by the Use of Ultra-highly-diluted Gonolobus Condurango Extract. · Journal of pharmacopuncture
- 4.PMID: 26088552 (2015) — Condurango 30C Induces Epigenetic Modification of Lung Cancer-specific Tumour Suppressor Genes via Demethylation. · Forschende Komplementarmedizin (2006)
- 5.PMID: 23807740