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Corydalis yanhusuo works primarily through L-tetrahydropalmatine (THP), a dopamine antagonist that blocks dopamine receptors in the central nervous system. This mechanism inhibits pain signal transmission and produces analgesic effects. THP also interacts with opioid receptors, enhancing pain relief. Additional compounds like corydaline and dehydrocorydaline contribute anti-inflammatory properties. This dual action on dopaminergic and opioid pathways makes it effective for various pain types. Evidence Level: C.
Does Corydalis interact with medications like antidepressants or sedatives?
Yes, Corydalis has significant drug interactions. It should never be combined with MAOIs (monoamine oxidase inhibitors), as this combination can cause dangerous hypertensive reactions. Because THP is a dopamine antagonist, it may interfere with dopamine agonists used for Parkinson's disease or certain antidepressants. Concurrent use with sedatives, benzodiazepines, or alcohol can cause excessive CNS depression. Always consult a healthcare provider before combining with prescription medications.
What is the recommended dosage for Corydalis yanhusuo?
The typical adult dosage is 5-10 grams of dried tuber as a decoction, or 500mg of standardized extract taken twice daily. Standardized extracts should contain verified levels of tetrahydropalmatine (THP). For acute pain, practitioners may recommend the higher dosage range. The herb is traditionally decocted with other Chinese herbs to enhance effects and reduce side effects. Evidence Level: Traditional/C.
Is Corydalis safe during pregnancy and breastfeeding?
No, Corydalis yanhusuo is contraindicated during pregnancy and breastfeeding. The active alkaloids, particularly THP, may stimulate uterine contractions and potentially cause miscarriage. These compounds cross the blood-brain barrier and may affect fetal neurological development. Women attempting to conceive should also avoid this herb. Traditional Chinese Medicine classifies Corydalis as a blood-moving herb, which is prohibited during pregnancy. Evidence Level: Traditional.
What are the side effects of taking Corydalis?
Common side effects include sedation, drowsiness, and dizziness due to its effects on the central nervous system. Users should not drive or operate heavy machinery after taking Corydalis. Some individuals may experience gastrointestinal upset, nausea, or headache. Side effects are typically dose-dependent and more common with higher doses. Discontinue use if experiencing severe dizziness, allergic reactions, or persistent digestive issues. Evidence Level: C.
What conditions does Corydalis yanhusuo treat?
Corydalis is used for acute and chronic pain management, including menstrual cramps (dysmenorrhea), chest pain from qi and blood stagnation, and traumatic injury pain. In Traditional Chinese Medicine, it promotes blood circulation and relieves pain. It also functions as a mild sedative and sleep aid. Modern research has explored its use for neuropathic pain and headache, though clinical evidence remains limited. Evidence Level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Corydalis yanhusuo is a traditional Asian medicinal herb primarily utilized for its potent analgesic properties [PMID:34946576, PMID:32223481].
Contexte
Corydalis yanhusuo (also known as yanhusuo, yuanhu, yanhu, or xuanhu) is a member of the Papaveraceae family, with the dried tuber serving as the primary medicinal organ [PMID:37729733, PMID:35003289, PMID:38004347]. It is distributed in regions of China such as Zhe Jiang, Shaan Xi, and Jiang Su [PMID:40708495].
Usages traditionnels
Traditionally used across Asia to relieve pain, motivate blood and Qi circulation, and treat digestive system diseases [PMID:34946576, PMID:37729733, PMID:36681166]. Specific traditional applications include the treatment of headache, abdominal pain, and epigastric pain [PMID:32223481].
Composés actifs
The herb contains over 160 compounds, including organic acids, volatile oils, amino acids, alcohols, and sugars [PMID:34946576, PMID:40708495]. The primary bioactive constituents are alkaloids (over 80 identified), categorized into protoberberine, aporphine, and opiate alkaloids [PMID:34946576, PMID:37729733]. Specific identified compounds include tetrahydropalmatine, corydaline, protopine, dehydrocorydaline, berberine, coptisine, and cavidine [PMID:20234973, PMID:34329130, PMID:40792414]. Polysaccharides (e.g., CYHSP-1 and CYHSP-2) are also present [PMID:40023428].
Mécanisme d'action
Analgesic effects are mediated through the inhibition of voltage-gated sodium channels [PMID:34329712] and the P2X3 receptor [PMID:39461390]. Other mechanisms include modulating neurotransmitters, ion channels, the HPA axis, and signaling pathways [PMID:37729733]. Specific compounds like yanhusanine J and tetrahydroberberine inhibit the NF-κB pathway [PMID:34839130, PMID:39238071], while others act as acetylcholinesterase (AChE) inhibitors [PMID:20234973, PMID:36758275]. Polysaccharides may regulate HPA-axis mediated microglia activation and 5-HT signaling via gut microbiota-derived short-chain fatty acids [PMID:40513699, PMID:38010856].
Preuves cliniques
Preuve CPain Management
Used as an analgesic agent for various conditions including headache, migraine, chest pain, abdominal pain, low back pain, and neuropathic pain [PMID:32054304, PMID:32223481].
Preuve CDrug Addiction
Rhizoma Corydalis may be used to prevent relapse to chronic drug dependence [PMID:28807162].
Preuve DMyocardial Ischemia
Quaternary ammonium alkaloids show significant effects on myocardial ischemia [PMID:28647508]; total alkaloids in Shuangshen Ningxin Capsule improved left ventricular function in rat models [PMID:37951149].
Preuve DDepression-like behavior
Corydalis yanhusuo polysaccharides improved depression-like behaviors and ameliorated hippocampal damage in CUMS-induced mice models [PMID:40513699, PMID:38010856].
Preuve DPostmenopausal Osteoporosis
Tetrahydroberberine (THB) mitigated ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis in vitro and in vivo [PMID:39238071].
Preuve D
Sécurité et effets indésirables
Processing and compatibility may alter the efficacy and safety of the herb [PMID:35003289]. No specific adverse effects are detailed in the provided abstracts, though the need for quality control is emphasized [PMID:32193434].
Synthèse des preuves
The evidence is primarily based on review articles (Level C) and preclinical animal or in vitro studies (Level D). There is strong preclinical evidence for analgesic, anti-inflammatory, and neuroprotective effects, but high-level clinical trial data (Level A/B) is not provided in the abstracts.
Sources PubMed
1.PMID: 34946576 (2021) — The Analgesic Properties of Corydalis yanhusuo. · Molecules (Basel, Switzerland)
2.PMID: 37729733 (2023) — The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
3.PMID: 32054304 (2020) — Effects of Herbal Medicines on Pain Management. · The American journal of Chinese medicine
4.PMID: 35003289 (2021) — Processing and Compatibility of Corydalis yanhusuo: Phytochemistry, Pharmacology, Pharmacokinetics, and Safety. · Evidence-based complementary and alternative medicine : eCAM
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Dehydrocorydaline attenuated bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation in mouse models [PMID:40221718].
Preuve DPeripheral Nerve Injury
Tetrahydropalmatine (THP) ameliorated peripheral nerve regeneration by enhancing macrophage anti-inflammatory response in rats [PMID:39765002].
· Brain research
6.PMID: 39238071 (2024) — Tetrahydroberberine Prevents Ovariectomy-Induced Bone Loss by Inhibiting RANKL-Induced Osteoclastogenesis and Promoting Osteoclast Apoptosis. · Journal of agricultural and food chemistry
7.PMID: 28807162 (2017) — Chinese Herbal Medicine for the Treatment of Drug Addiction. · International review of neurobiology
8.PMID: 28647508 (2017) — Fingerprint-efficacy study of the quaternary alkaloids in Corydalis yanhusuo. · Journal of ethnopharmacology
9.PMID: 34839130 (2022) — 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity. · Phytochemistry
10.PMID: 20234973 (2011) — Acetylcholinesterase inhibitors from Corydalis yanhusuo. · Natural product research
11.PMID: 40221718 (2025) — Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation. · Respiratory research
12.PMID: 38910886 (2024) — Exploring the role of Chinese herbal medicine in the long-term management of postoperative ovarian endometriotic cysts: a systematic review and meta-analysis. · Frontiers in pharmacology
13.PMID: 38004347 (2023) — Integrating Full-Length and Second-Generation Transcriptomics to Reveal Differentially Expressed Genes Associated with the Development of Corydalis yanhusuo Tuber. · Life (Basel, Switzerland)
14.PMID: 39461390 (2025) — The analgesic effect and mechanism of the active components screening from Corydalis yanhusuo by P2X3 receptors. · Journal of ethnopharmacology
15.PMID: 36681166 (2023) — Gastroprotective action of the extract of Corydalis yanhusuo in Helicobacter pylori infection and its bioactive component, dehydrocorydaline. · Journal of ethnopharmacology
16.PMID: 37951149 (2024) — Investigation of the active ingredients of Shuangshen Ningxin Fomula and the mechanism underlying their protective effects against myocardial ischemia-reperfusion injury by mass spectrometric imaging. · Phytomedicine : international journal of phytotherapy and phytopharmacology
17.PMID: 40792414 (2025) — Investigating the Components Change of Steamed Corydalis yanhusuo via Mass Spectrometry Imaging, HS-GC-IMS, HPLC, and Network Pharmacology to Unveil Mechanism for Antichronic Atrophic Gastritis. · Biomedical chromatography : BMC
18.PMID: 28911575 (2016) — Recent progress on the traditional Chinese medicines that regulate the blood. · Journal of food and drug analysis
19.PMID: 39765002 (2025) — Tetrahydropalmatine ameliorates peripheral nerve regeneration by enhancing macrophage anti-inflammatory response. · International immunopharmacology
20.PMID: 36758275 (2023) — (±)-Yanhusuomide A, a pair of ornithine-fused benzylisoquinoline enantiomers from Corydalis yanhusuo. · Bioorganic chemistry
21.PMID: 32193434 (2020) — Quality Evaluation of Corydalis yanhusuo by High-Performance Liquid Chromatography Fingerprinting Coupled with Multicomponent Quantitative Analysis. · Scientific reports
22.PMID: 32223481 (2020) — Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis. · Pharmaceutical biology
23.PMID: 35069636 (2021) — Peanut Rotation and Flooding Induce Rhizobacteriome Variation With Opposing Influences on the Growth and Medicinal Yield of Corydalis yanhusuo. · Frontiers in plant science
24.PMID: 40023428 (2025) — Structural characterization of Corydalis yanhusuo polysaccharides and its bioactivity in vitro. · International journal of biological macromolecules
25.PMID: 38876472 (2024) — Fu'cupping Physical Permeation-Enhancing Technique Enhances the Therapeutic Efficacy of Corydalis yanhusuo Gel Plaster. · Planta medica
26.PMID: 38010856 (2023) — Corydalis yanhusuo Polysaccharides Ameliorate Chronic Stress-Induced Depression in Mice through Gut Microbiota-Derived Short-Chain Fatty Acid Activation of 5-Hydroxytryptamine Signaling. · Journal of medicinal food
27.PMID: 40708495 (2025) — Ethnomedicine, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Rhizoma Corydalis: A Systematic Review. · The American journal of Chinese medicine
28.PMID: 34329712 (2021) — Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels. · Journal of ethnopharmacology
29.PMID: 41220036 (2025) — Rotation of Corydalis yanhusuo with different crops enhances its quality and soil nutrients: a multi-dimensional analysis of rhizosphere microecology. · BMC plant biology