Croton tiglium (Croton tiglium): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Croton tiglium work as a purgative?

Croton tiglium works through its active phorbol esters, which are potent irritants to the gastrointestinal mucosa. These compounds, particularly 12-O-tetradecanoylphorbol-13-acetate (TPA), stimulate smooth muscle contraction and increase intestinal secretion via activation of protein kinase C. This intense irritation triggers a violent cathartic effect. Unlike gentle laxatives, the mechanism relies on chemical irritation, which accounts for its severe side effects and why it is no longer used therapeutically (Evidence Level: C, Mechanism: Phorbol esters irritate GI mucosa).

Can I take Croton tiglium with other medications?

Croton tiglium should not be taken with any medications due to its extreme toxicity and contraindication for internal use. The severe gastrointestinal irritation it causes can alter the absorption of oral drugs, potentially leading to unpredictable plasma levels. Furthermore, combining it with other laxatives or GI-irritating substances would compound toxicity risks. Because modern medical practice strongly advises against internal use, drug interaction studies are limited, but the theoretical risk of dangerous interactions is considered high (Evidence Level: D).

What is the safe dosage for Croton tiglium?

There is no safe recommended dosage for self-medication with Croton tiglium. The plant and its oil are classified as extremely toxic, with a very narrow margin between a therapeutic dose and a lethal one. Historical texts mention doses as low as 1-2 drops of croton oil, but even these minute amounts can cause severe gastrointestinal distress, blistering, and systemic toxicity. Modern herbalists and medical professionals strongly advise against any internal or topical use (Evidence Level: C/D).

Is Croton tiglium safe during pregnancy?

Croton tiglium is absolutely unsafe during pregnancy and breastfeeding. The phorbol esters present in the plant are potent toxins that can cause severe irritation to the digestive tract and skin. Internal use induces violent purgation, which can stimulate uterine contractions and lead to miscarriage or premature labor. Additionally, the risk of systemic toxicity and severe dehydration from purging poses a significant threat to fetal development. It is strictly contraindicated (Evidence Level: D).

Why is Croton tiglium used in cancer research?

Croton tiglium is used in cancer research primarily because of its phorbol esters, specifically TPA. These compounds act as potent tumor promoters in laboratory models, making them valuable tools for studying cell signaling pathways, particularly the protein kinase C (PKC) pathway. Researchers use these compounds to understand how cells become malignant and to investigate mechanisms of carcinogenesis. This research application is distinct from any therapeutic use, as the compounds themselves are not used to treat cancer in humans (Evidence Level: A, for research tool utility).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Croton tiglium is an ancient medicinal plant used primarily for its purgative effects and in deep chemical peels [PMID:35723937, PMID:30550827].

Contexte

Croton tiglium Linn. (Euphorbiaceae) is a plant widely distributed in tropical and subtropical regions [PMID:35723937].

Usages traditionnels

It has been used traditionally for defecation, inducing labour, treating gastrointestinal diseases, headache, and rheumatoid arthritis [PMID:35723937]. In Traditional Chinese Medicine, it is used as a laxative, analgesic, and antibacterial agent [PMID:32357169, PMID:37923254].

Composés actifs

The plant contains approximately 150 compounds, including fatty acids (linoleic, oleic, and eicosenoic acid), terpenoids, alkaloids, and proteins [PMID:35723937, PMID:23252276]. Key bioactive components include phorbol esters (such as phorbol 12-tiglate 13-decanoate) and tigliane-type diterpenes [PMID:1251193, PMID:38257314, PMID:36795010].

Mécanisme d'action

Tiglium seed extract may inhibit gap junctional intercellular communication (GJIC) via the phosphorylation of connexin43 (Cx43) and ERK1/2, a process regulated by protein kinase C (PKC) and MAPK signaling pathways [PMID:25391291]. In lung cancer cells, it induces apoptosis via the Bax/Bcl-2 pathway [PMID:28032492].

Preuves cliniques

Preuve CDeep facial resurfacing/Wrinkles

Phenol-croton oil peels are used for deep facial resurfacing to improve wrinkles and tighten skin; the depth of penetration can be modified by varying croton oil concentration [PMID:30550827].

Preuve DConstipation

Processed Croton tiglium seeds (Crotonis Semen Pulveratum) ameliorate loperamide-induced constipation in mouse models [PMID:37923254].

Preuve DDermatophytosis

Ethanolic extracts of stems, leaves, and seeds show antifungal activity against Trichophyton mentagrophytes, T. rubrum, and Epidermophyton floccosum [PMID:27446946].

Preuve DLung Cancer (A549 cells)

Essential oil and methanol extracts exhibit anti-proliferative and pro-apoptotic effects in vitro [PMID:32357169, PMID:28032492].

Sécurité et effets indésirables

Croton tiglium is known for its toxicity and severe purgative action [PMID:25538350]. Seed extracts have demonstrated mutagenic potential in Ames assays [PMID:25391291] and developmental toxicity in zebrafish, causing pericardial edema, yolk sac edema, and spinal curvature [PMID:31902256]. Phorbol esters are identified as irritants and cocarcinogens [PMID:4609865].

Synthèse des preuves

The evidence consists primarily of in vitro studies, animal models, and literature reviews. There is a strong emphasis on the plant's toxicity and the necessity of purification processes (Shodhana) to reduce cytotoxicity and mutagenicity [PMID:37230917, PMID:25538350].

Sources PubMed

1.PMID: 30216064 (2018) — Phorbol Rearrangements. · Journal of natural products
2.PMID: 30550827 (2019) — Advanced chemical peels: Phenol-croton oil peel. · Journal of the American Academy of Dermatology
3.PMID: 35723937 (2022) — Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review. · The Journal of pharmacy and pharmacology
4.PMID: 38257314 (2024) — Diterpenoids with Schistosomula-Killing and Anti-Fibrosis Activities In Vitro from the Leaves of Croton tiglium. · Molecules (Basel, Switzerland)
5.PMID: 37230917 (2023) — Impact of Shodhana an Ayurvedic purification process on cytotoxicity and mutagenicity of Croton tiglium Linn. · Journal of Ayurveda and integrative medicine

Croton tiglium

Sources et citations

Calculer une dose sûre de Croton tiglium

Manihot esculenta

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Cassia sieberiana

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Croton tiglium

Sources et citations

Calculer une dose sûre de Croton tiglium

Plantes associées

Manihot esculenta

Gleditsia japonica

Cassia sieberiana

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales