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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Croton tiglium
Euphorbiaceae asiatique ; huile de croton issue des graines est un purgatif ; esters phorbol utilisés en recherche sur le cancer.
Croton tiglium is a highly toxic plant from the Euphorbiaceae family, historically used as a drastic purgative and for skin conditions. Its seeds contain phorbol esters, which are potent tumor promoters and are used in cancer research to study signal transduction pathways. Despite traditional applications, its extreme toxicity precludes any internal or external medicinal use in modern practice.
The primary active compounds are phorbol esters (e.g., 12-O-tetradecanoylphorbol-13-acetate, TPA) that activate protein kinase C (PKC) by mimicking diacylglycerol, leading to downstream effects on cell proliferation, differentiation, and inflammation. This PKC activation also induces prostaglandin synthesis and intestinal peristalsis, explaining the purgative action. Additionally, croton oil causes severe irritation and inflammation via activation of NF-κB and MAPK pathways, resulting in vesication and tissue damage.
Euphorbiaceae asiatique ; huile de croton issue des graines est un purgatif ; esters phorbol utilisés en recherche sur le cancer.
Croton tiglium is a highly toxic plant from the Euphorbiaceae family, historically used as a drastic purgative and for skin conditions. Its seeds contain phorbol esters, which are potent tumor promoters and are used in cancer research to study signal transduction pathways. Despite traditional applications, its extreme toxicity precludes any internal or external medicinal use in modern practice.
The primary active compounds are phorbol esters (e.g., 12-O-tetradecanoylphorbol-13-acetate, TPA) that activate protein kinase C (PKC) by mimicking diacylglycerol, leading to downstream effects on cell proliferation, differentiation, and inflammation. This PKC activation also induces prostaglandin synthesis and intestinal peristalsis, explaining the purgative action. Additionally, croton oil causes severe irritation and inflammation via activation of NF-κB and MAPK pathways, resulting in vesication and tissue damage.