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Dryopteris filix-mas
Parme historique utilisée pour expulser les vers solitaires ; toxicité en excès ; anthelminthique historique significatif.
Dryopteris filix-mas, a European fern historically used as an anthelmintic for tapeworm expulsion, contains phloroglucinol derivatives such as filicin and flavaspidic acid. Its use is now obsolete due to significant toxicity, including hepatotoxicity and neurotoxicity, and has been replaced by safer modern anthelmintics.
The anthelmintic action of Dryopteris filix-mas is attributed to phloroglucinol compounds (e.g., filicin, flavaspidic acid) that inhibit mitochondrial oxidative phosphorylation in parasitic tapeworms, leading to energy depletion and paralysis. These compounds also interfere with glucose uptake and disrupt the tegument integrity of the parasite. In humans, the same mitochondrial toxicity can cause severe hepatotoxicity and, at high doses, optic nerve damage leading to blindness, likely due to inhibition of complex I of the electron transport chain.
Parme historique utilisée pour expulser les vers solitaires ; toxicité en excès ; anthelminthique historique significatif.
Dryopteris filix-mas, a European fern historically used as an anthelmintic for tapeworm expulsion, contains phloroglucinol derivatives such as filicin and flavaspidic acid. Its use is now obsolete due to significant toxicity, including hepatotoxicity and neurotoxicity, and has been replaced by safer modern anthelmintics.
The anthelmintic action of Dryopteris filix-mas is attributed to phloroglucinol compounds (e.g., filicin, flavaspidic acid) that inhibit mitochondrial oxidative phosphorylation in parasitic tapeworms, leading to energy depletion and paralysis. These compounds also interfere with glucose uptake and disrupt the tegument integrity of the parasite. In humans, the same mitochondrial toxicity can cause severe hepatotoxicity and, at high doses, optic nerve damage leading to blindness, likely due to inhibition of complex I of the electron transport chain.