Evodia Rutaecarpa (Evodia rutaecarpa): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Evodia rutaecarpa work in the body?

Evodia rutaecarpa contains bioactive alkaloids, primarily evodiamine and rutaecarpine, which act on transient receptor potential vanilloid (TRPV1) channels. These compounds stimulate calcium influx and promote vasodilation, contributing to their warming and analgesic effects. Evodiamine also modulates serotonin receptors and exhibits anti-inflammatory activity by inhibiting NF-κB signaling. These mechanisms support its traditional use for warming the liver, relieving pain, and dispersing cold stagnation in Traditional Chinese Medicine. Evidence level: C.

Does Evodia rutaecarpa interact with any medications?

Evodia rutaecarpa may interact with medications metabolized by cytochrome P450 enzymes, particularly CYP1A2, CYP2C9, and CYP3A4. Evodiamine and rutaecarpine can inhibit these enzymes, potentially increasing blood levels of drugs like theophylline, warfarin, and certain statins. Additionally, its potential blood pressure-lowering effects may enhance antihypertensive medications. Patients taking prescription medications should consult a healthcare provider before using Evodia rutaecarpa. Evidence level: C.

What is the recommended dosage for Evodia rutaecarpa?

The typical adult dosage of Evodia rutaecarpa is 1.5–4.5 grams of dried fruit as a decoction, taken 2-3 times daily. Standardized extracts containing approximately 100mg of evodiamine are also available. Due to potential hepatotoxicity at higher doses, treatment duration should be limited, and dosing should be supervised by a qualified practitioner. Dosage adjustments may be necessary based on individual tolerance and the specific condition being treated. Evidence level: Traditional/C.

Is Evodia rutaecarpa safe during pregnancy and breastfeeding?

Evodia rutaecarpa is contraindicated during pregnancy and breastfeeding. The herb has emmenagogue properties that may stimulate uterine contractions, potentially leading to miscarriage. Traditional Chinese Medicine classifies it as unsafe for pregnant women due to its warming and moving properties. Insufficient safety data exists for lactating women and children. Women who are pregnant, planning pregnancy, or breastfeeding should avoid this herb entirely. Evidence level: Traditional.

What are the side effects of Evodia rutaecarpa?

Common side effects of Evodia rutaecarpa include nausea, dry mouth, and mild gastrointestinal discomfort. More serious concerns involve potential hepatotoxicity at high doses or with prolonged use, as the alkaloids evodiamine and rutaecarpine may stress liver function. The herb is contraindicated in individuals with heat conditions, yin deficiency, or existing liver disease. Discontinue use if jaundice, dark urine, or persistent abdominal pain occurs. Evidence level: C.

What conditions is Evodia rutaecarpa traditionally used to treat?

Evodia rutaecarpa is traditionally used in Chinese Medicine to warm the liver, relieve pain, stop vomiting, and treat cold-stagnation conditions. Common applications include cold abdominal pain, chronic diarrhea from cold, headache, and nausea. It is also used for hypertension in modern herbal practice due to its vasodilatory effects. The herb's warming properties make it particularly suited for conditions characterized by cold and stagnation in the middle and lower jiao. Evidence level: Traditional/C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Evodia rutaecarpa is a traditional Chinese medicinal herb used for various ailments, containing bioactive indole alkaloids with cardiovascular, gastrointestinal, and neuroprotective properties [PMID:30616017, PMID:37741256].

Contexte

Evodia rutaecarpa (also known as Wu Zhu Yu) is a tree native to China and Korea, from which the near-ripe or dry unripened fruit is used as a medicinal herb [PMID:30616017, PMID:37741256, PMID:27771931, PMID:35463684].

Usages traditionnels

In China, it is clinically used to treat headache, abdominal pain, abdominal distension, vomiting, diarrhea, postpartum hemorrhage, dysentery, and amenorrhea [PMID:30616017, PMID:37741256, PMID:35379148].

Composés actifs

The major bioactive compounds are indole alkaloids, specifically evodiamine (EVO), rutaecarpine (RUT), and dehydroevodiamine (DHE) [PMID:37741256, PMID:19471205]. Other identified components include evodol (a furanoid) [PMID:37092795].

Mécanisme d'action

Rutaecarpine targets TRPV1, CGRP, AMPK, ABCA1, and β1-AR [PMID:30616017], and protects endothelial cells via TRPV1- and AhR-mediated Nrf2 activation [PMID:40427497]. Evodiamine may induce PANoptosis in microglia to reduce neuroinflammation [PMID:41242627], induce ferroptosis in prostate cancer cells by inhibiting TRIM26-mediated stabilization of GPX4 [PMID:40420092], and regulate the C/EBP-β-COX2 axis to attenuate neuroinflammation [PMID:39798734].

Preuves cliniques

Preuve BChemotherapy-induced nausea and vomiting (CINV)

Hezhong granules (containing Evodia rutaecarpa) are used to prevent CINV in patients with advanced colorectal cancer [PMID:38341113]

Preuve ADigestive system diseases

Evodiamine has a positive therapeutic effect on various digestive system diseases, including colorectal cancer, gastric ulcers, liver cancer, liver fibrosis, and ulcerative colitis [PMID:39018943]

Preuve CAlzheimer's Disease

Bioactive alkaloid components can ameliorate cognitive impairments and neurological damage through anti-inflammatory, antioxidant, and anti-acetylcholinesterase activities [PMID:38173117]

Preuve DIschemic Stroke

Rutaecarpine showed therapeutic effects against ischemic stroke, involving the MAPK pathway and targets such as MMP-9 and caspase 3 [PMID:40577347]

Preuve DSevere Traumatic Brain Injury (sTBI)

Evodiamine attenuated cerebral edema and reduced neuroinflammation in murine models [PMID:41242627]

Sécurité et effets indésirables

Evodiamine has been reported to have potential toxic effects, including hepatotoxicity, nephrotoxicity, and cardiac toxicity [PMID:39345907].

Interactions médicamenteuses

Pretreatment with rutaecarpine, Evodia rutaecarpa extract, or Wu-Chu-Yu-Tang significantly decreased caffeine levels in rats [PMID:16041650]. Evodol, a furanoid from the fruit, inactivates cytochrome P450 3A (CYP3A) [PMID:37092795].

Synthèse des preuves

The evidence consists primarily of in vitro studies, animal models (D), and systematic reviews of experimental data (A/C), with limited clinical trial data (B) regarding specific formulations for nausea.

Sources PubMed

1.PMID: 30616017 (2019) — Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu). · Pharmacological research
2.PMID: 21579570 (2010) — 2-[2-(Methyl-amino)-benzo-yl]-2,3,4,9-tetra-hydro-1H-pyrido[3,4-b]indol-1-one. · Acta crystallographica. Section E, Structure reports online
3.PMID: 22346943 (2012) — Evodiamide. · Acta crystallographica. Section E, Structure reports online
4.PMID: 37741256 (2023) — Major Indole Alkaloids in Evodia Rutaecarpa: The Latest Insights and Review of Their Impact on Gastrointestinal Diseases. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
5.PMID: 18305418 (2008) — Progress in the studies on rutaecarpine. · Molecules (Basel, Switzerland)

Evodia Rutaecarpa

Sources et citations

Calculer une dose sûre de Evodia Rutaecarpa

Alpinia Katsumadai

Cassytha Filiformis

Rauvolfia vomitoria

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Evodia Rutaecarpa

Sources et citations

Calculer une dose sûre de Evodia Rutaecarpa

Plantes associées

Alpinia Katsumadai

Cassytha Filiformis

Rauvolfia vomitoria

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales