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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Polygonum multiflorum, known as Fo-Ti or He Shou Wu, is a traditional Chinese medicinal herb used for anti-aging and various systemic conditions, though it is strongly associated with hepatotoxicity [PMID:31644102, PMID:30895364].
Contexte
Polygonum multiflorum (Fo-Ti, He Shou Wu, Chinese knotweed) is a perennial plant native to China [PMID:31644102, PMID:38953108]. It is widely used in East Asia and North America as a traditional medicine [PMID:26130933].
Usages traditionnels
Traditional uses include treatment for backache, dizziness, liver disease, graying of the hair, constipation [PMID:31644102], as well as serving as a liver and kidney tonic for longevity and hair blackening [PMID:30895364, PMID:25449462].
Composés actifs
The herb contains stilbenes (notably 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside or TSG), quinones (including anthraquinones like emodin, aloe-emodin, rhein, and physcion), flavonoids, phospholipids, and polysaccharides [PMID:30895364, PMID:31644102, PMID:31680350, PMID:26185519, PMID:35069206, PMID:42191038].
Mécanisme d'action
TSG exhibits anti-aging effects by alleviating oxidative stress, inflammation, and apoptosis [PMID:40244282]. Extracellular vesicle-like nanovesicles from the plant reduce UV-induced oxidative stress, inhibit matrix metalloproteinase production, and promote collagen synthesis [PMID:39703536]. Emodin is involved in modulating inflammatory responses, apoptosis, and oxidative damage in cardiovascular contexts [PMID:36618923].
Preuves cliniques
Preuve DSkin Photoaging
Plant-derived extracellular vesicle-like nanovesicles (PMELNVs) showed antioxidative properties and anti-photoaging effects by reducing extracellular matrix degradation [PMID:39703536]
Preuve DAlzheimer's Disease
A formula combining Panax ginseng and Polygonum multiflorum (GSPM) showed potential neuroprotective effects in SAMP8 mice, improving cognitive function [PMID:40051562]
Preuve AAging and Age-related diseases
TSG demonstrates comprehensive anti-aging effects, including lifespan extension, neuroprotection (Alzheimer's and Parkinson's), cardiovascular protection, and promotion of hair regrowth [PMID:40244282]
Preuve CPeriodontitis
TSG possesses anti-inflammatory properties and is suggested as a possible complementary treatment for Porphyromonas gingivalis-induced inflammatory responses [PMID:28856691]
Sécurité et effets indésirables
Polygonum multiflorum is implicated in numerous reports of clinically apparent acute liver injury, which can be severe or fatal [PMID:31644102]. Hepatotoxicity may be immune-mediated idiosyncratic liver injury [PMID:32123300] and is associated with components such as free anthraquinones (emodin, chrysophanol, physcion), cis-stilbene glycosides, and dianthrones [PMID:42278266]. Clinical features of liver injury include jaundice (79.3% of cases in one study) and patterns of acute cholestatic hepatitis or hepatocellular injury [PMID:30066422]. Nephrotoxicity has also been reported in relation to aloe-emodin [PMID:31680350].
Synthèse des preuves
Evidence for anti-aging and neuroprotective effects is supported by systematic reviews and animal models, while evidence for hepatotoxicity is strong across multiple clinical reports and reviews.
Sources PubMed
1.PMID: 31644102 (2012) — Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics. · CITED REFERENCE
2.PMID: 31680350 (2020) — Aloe-emodin: A review of its pharmacology, toxicity, and pharmacokinetics. · Phytotherapy research : PTR
3.PMID: 39703536 (2024) — Polygonum multiflorum Extracellular Vesicle-Like Nanovesicle for Skin Photoaging Therapy. · Biomaterials research
4.PMID: 34307603 (2021) — Herb-induced liver injury: Systematic review and meta-analysis. · World journal of clinical cases
5.PMID: 30895364 (2019) — Attributes of Polygonum multiflorum to transfigure red biotechnology. · Applied microbiology and biotechnology
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 30066422 (2019) — Clinicopathological features of He Shou Wu-induced liver injury: This ancient anti-aging therapy is not liver-friendly. · Liver international : official journal of the International Association for the Study of the Liver
7.PMID: 26185519 (2015) — Rhein: A Review of Pharmacological Activities. · Evidence-based complementary and alternative medicine : eCAM
8.PMID: 39038664 (2024) — Research progress on hepatotoxicity mechanism of polygonum multiflorum and its main components. · Toxicon : official journal of the International Society on Toxinology
9.PMID: 28920378 (2016) — [Chemical constituents from Polygonum multiflorum]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
10.PMID: 40051562 (2025) — Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer's disease. · Frontiers in pharmacology
11.PMID: 29713283 (2018) — Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity. · Frontiers in pharmacology
12.PMID: 32123300 (2021) — The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury. · Acta pharmacologica Sinica
13.PMID: 38953108 (2024) — Phytochemistry, pharmacology, toxicology and detoxification of Polygonum multiflorum Thunb.: a comprehensive review. · Frontiers in pharmacology
14.PMID: 36119015 (2020) — New phenolic constituents obtained from Polygonum multiflorum. · Chinese herbal medicines
15.PMID: 35069206 (2021) — A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside. · Frontiers in pharmacology
16.PMID: 40244282 (2025) — 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging. · International journal of molecular sciences
17.PMID: 26130933 (2015) — Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds. · Pharmacognosy research
18.PMID: 33485980 (2021) — Polygonum multiflorum: Recent updates on newly isolated compounds, potential hepatotoxic compounds and their mechanisms. · Journal of ethnopharmacology
19.PMID: 42191038 (2026) — Polysaccharides from Polygonum multiflorum Thunb. and its processed products: A review on traditional uses, extraction, structural characteristics, pharmacological activities, structure-activity relationships, and drug delivery applications. · Fitoterapia
21.PMID: 31920657 (2019) — Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges. · Frontiers in pharmacology
22.PMID: 38087457 (2024) — Phytochemical analysis and hepatotoxicity assessment of braised Polygoni Multiflori Radix (Wen-He-Shou-Wu). · Biomedical chromatography : BMC
23.PMID: 36618923 (2022) — Emodin in cardiovascular disease: The role and therapeutic potential. · Frontiers in pharmacology
24.PMID: 33261537 (2021) — Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review. · Current drug metabolism
25.PMID: 25449462 (2015) — Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review. · Journal of ethnopharmacology
26.PMID: 28856691 (2017) — Therapeutic applications of resveratrol and its derivatives on periodontitis. · Annals of the New York Academy of Sciences
27.PMID: 42278266 (2026) — Hepatotoxic Compounds and Mechanisms of Polygonum Multiflorum: A Narrative Review of Recent Advances. · International journal of molecular sciences
28.PMID: 35183691 (2022) — Pharmacokinetics and metabolism of trans-emodin dianthrones in rats. · Journal of ethnopharmacology