Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 12 articles PubMed · modèle : gemma4:31b
Résumé
Citri Reticulatae Pericarpium Viride (Qing Pi) is a traditional Chinese medicinal herb used for Qi-regulation and the treatment of anxiety and depression [PMID:38735421].
Contexte
Citri Reticulatae Pericarpium Viride, also known as Qing Pi or green tangerine peel, is a plant in the Rutaceae family [PMID:38735421]. It is categorized into different commodity specifications, such as Si Hua Qing Pi (SHQP) and Ge Qing Pi (GQP), based on harvesting time [PMID:33977590].
Usages traditionnels
It is used as a traditional Qi-regulating medicine in Chinese medicine and has extensive clinical practice in treating anxiety and depression [PMID:38735421].
Composés actifs
The herb contains biologically valuable flavonoids [PMID:33977590], specifically polymethoxylated flavones (PMFs) including nobiletin (40.5%), tangeretin (45.6%), 5-demethylnobiletin (8.7%), and sinensetin (1.7%) [PMID:17367982]. Other identified compounds include hesperidin, neohesperidin, and naringenin [PMID:12212096, PMID:41475204].
Mécanisme d'action
Qing Pi essential oil may improve anxiety-like behavior by regulating Glu/NMDAR on the olfactory bulb [PMID:38735421]. Its pharmacological benefits are attributed to antioxidant capacities and neuroprotective effects [PMID:38735421]. Certain polymethoxylated flavonoids in the peel are noted for strong antitumor activity [PMID:35668040].
Preuves cliniques
Preuve DAnxiety
Essential oil of Citri Reticulata Pericarpium Viride was evaluated for its ability to improve anxiety-like behavior via Glu/NMDAR regulation in animal models [PMID:38735421]
Preuve BChronic viral hepatitis B with compensated liver cirrhosis
Green tangerine peel was used as a component of the Xiaozhang Recipe (XR) in a clinical trial to assess efficacy alongside lamivudine [PMID:22013800]
Synthèse des preuves
The evidence consists primarily of phytochemical profiling and animal-based pharmacological studies (Level D), with limited clinical trial data (Level B) where the herb is used as part of a multi-ingredient formula.
Sources PubMed
- 1.PMID: 33977590 (2021) — Simultaneous quantitative analysis of ten bioactive flavonoids in Citri Reticulatae Pericarpium Viride (Qing Pi) by ultrahigh-performance liquid chromatography and high-resolution mass spectrometry combined with chemometric methods. · Phytochemical analysis : PCA
- 2.PMID: 38735421 (2024) — Neuro-stimulating effect of Citri Reticulata Pericarpium Viride essential oil through regulating Glu/NMDAR on olfactory bulb to improve anxiety-like behavior. · Journal of ethnopharmacology
- 3.PMID: 35668040 (2022) — Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering-based high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. · Phytochemical analysis : PCA
- 4.PMID: 17367982 (2007) — Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. · Journal of pharmaceutical and biomedical analysis