PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 27 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Methanol-aqueous extract (150-300 mg/kg bw) in rats significantly reduced blood glucose (by ~20%), lipase activity (by 52%), total cholesterol (by 50%), and triglycerides (by 57%) [PMID:39124206].
Leaf extract (150-300 mg/kg) in diabetic rats decreased blood glucose, lowered systolic pressure, reduced urea and creatinine levels, and alleviated proteinuria [PMID:40699692].
Parthenolide inhibited cytotoxicity and cardiomyocyte apoptosis in H9c2 cells and C57BL/6J mice [PMID:41262674].
Parthenolide improved peritoneal fibrosis in PD mice by selectively inhibiting the phosphorylation of Smad2/3 [PMID:36307537].
Parthenolide (100 uM and 200 uM) significantly accelerated wound repair in diabetic mouse models by enhancing keratinocyte proliferation and angiogenesis [PMID:42337164].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 36616151 (2022) — An In-Depth Study of Metabolite Profile and Biological Potential of Tanacetum balsamita L. (Costmary). · Plants (Basel, Switzerland)
- 2.PMID: 40805755 (2025) — Sustainable Agronomical Practices Affect Essential Oil Composition of Tanacetum balsamita L. · Plants (Basel, Switzerland)
- 3.PMID: 34961198 (2021) — Allelopathic Effects of Essential Oils on Seed Germination of Barley and Wheat. · Plants (Basel, Switzerland)
- 4.PMID: 36616147 (2022) — Antiviral Activity of Selected Essential Oils against Cucumber Mosaic Virus. · Plants (Basel, Switzerland)
- 5.PMID: 34791965 (2023) — A new eudesmanolide from Tanacetum balsamita L. and biological activities of extracts.