Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
PubMed · Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. (2024)
PubMed · The Effectiveness of <i>Rhodiola rosea</i> L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. (2022)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Fu Zi Hong Jing Tian
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
Fu Zi Hong Jing Tian contains active compounds including salidroside, rosavins, and tyrosol, which appear to modulate the body's stress response system. Research suggests these compounds may influence neurotransmitters like serotonin and dopamine while supporting mitochondrial energy production. The herb is believed to enhance oxygen utilization at the cellular level, which may explain its traditional use for altitude adaptation. Salidroside has demonstrated antioxidant and neuroprotective properties in preclinical studies. Evidence level: C (preliminary clinical evidence).
Can Rhodiola crenulata interact with medications?
Yes, Fu Zi Hong Jing Tian may interact with certain medications. Due to its stimulant-like properties, it should not be combined with stimulant medications or caffeine-containing products without medical supervision. The herb may also interact with antidepressants, particularly MAO inhibitors and SSRIs, potentially increasing the risk of serotonin syndrome or excessive stimulation. Individuals taking blood pressure or cardiovascular medications should consult a healthcare provider, as Rhodiola species may affect cardiovascular function. Always disclose all supplements to your prescribing physician.
What is the recommended dosage for Fu Zi Hong Jing Tian?
The typical adult dosage for Rhodiola crenulata is 200-400mg of standardized extract daily, or 3-6 grams of dried root prepared as a decoction. Standardized extracts should contain consistent levels of salidroside and rosavins for reliable effects. For altitude sickness prevention, begin supplementation several days before ascent. Take doses earlier in the day to avoid sleep disruption. Clinical evidence for optimal dosing remains limited (Evidence level: C), so follow product-specific recommendations and consult a qualified practitioner for personalized guidance.
Is Fu Zi Hong Jing Tian safe during pregnancy and breastfeeding?
Fu Zi Hong Jing Tian is contraindicated during pregnancy and should be avoided. The herb's stimulant properties and effects on uterine tissue pose potential risks to fetal development and pregnancy maintenance. There is insufficient safety data for use during breastfeeding, so nursing mothers should also avoid this herb. Women attempting to conceive should discontinue use. Traditional Tibetan medicine texts historically restricted use in pregnant populations. Consult a qualified healthcare provider for safe alternatives to manage fatigue or altitude concerns during pregnancy.
What is the difference between Rhodiola crenulata and Rhodiola rosea?
Rhodiola crenulata (Fu Zi Hong Jing Tian) and Rhodiola rosea are distinct species with different phytochemical profiles and traditional uses. R. crenulata grows at higher altitudes in Tibet and the Himalayas and contains higher concentrations of salidroside relative to rosavins. R. rosea, native to Arctic and European regions, typically contains more rosavins. Both species share adaptogenic properties, but R. crenulata has stronger traditional documentation for altitude sickness in Tibetan Sowa Rigpa medicine. Most clinical research has focused on R. rosea, so evidence for R. crenulata remains more limited.
What are the side effects of Fu Zi Hong Jing Tian?
Fu Zi Hong Jing Tian is generally well-tolerated at recommended doses, but some users report side effects. The most common complaint is insomnia or sleep disturbance, particularly when taken late in the day due to the herb's stimulating properties. Mild gastrointestinal effects including nausea or stomach discomfort may occur in some individuals. People with bipolar disorder should avoid this herb, as it may trigger manic episodes. Headaches and irritability have been reported occasionally. Discontinue use if you experience persistent adverse effects and consult a healthcare provider.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Rhodiola crenulata is a traditional Tibetan medicinal herb used primarily for treating high-altitude sickness and fatigue [PMID:38503156, 40699724]. It demonstrates neuroprotective, antioxidant, and anti-inflammatory properties across various models [PMID:37955364, 27224273].
Contexte
Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba is a perennial herbaceous plant of the Crassulaceae family found in cold high-altitude regions (2800 to 5600m), primarily distributed in China, Nepal, and Bhutan [PMID:41936838, 38615983]. The roots are the primary medicinal part of the plant [PMID:41936838].
Usages traditionnels
Traditionally used in Tibetan and Eastern medicine to treat high-altitude sickness, fatigue, diabetes, hemoptysis, pneumonia, cough, and gynecological disorders such as leucorrhea [PMID:40504978, 41936838, 40699724].
Composés actifs
Key bioactive components include salidroside (a major compound), tyrosol, crenulatin, catechin gallate, eriodictyol, rhodiooctanoside, quercetin, luteolin, kaempferol, and ellagic acid [PMID:27224273, 40699724, 41226160].
Mécanisme d'action
Mechanisms include activation of the AMPK pathway to regulate glucose and lipid metabolism [PMID:28830211, 25925970], stimulation of the PI3K-AKT-MAPK signaling pathway to enhance mitochondrial function [PMID:36610162], and regulation of the AMPK/Sirt1/HIF-1α pathway for mitochondrial protection [PMID:40354296]. It also inhibits the Wnt/β-catenin signaling pathway in glioblastoma [PMID:25998182] and regulates the decadienylcarnitine/NLRP3/GSDMD axis to inhibit cell pyroptosis [PMID:40850654].
Preuves cliniques
Preuve AAcute High Altitude Disease (AHAD)
Rhodiola crenulata extract (RCE) is effective in improving arterial oxygen saturation (SaO2) and arterial partial pressure of oxygen (PaO2) [PMID:40584626]
Preuve BAerobic Exercise Performance
Supplementation of R. crenulata and Cordyceps sinensis during high altitude training markedly lengthened exhaustive run time compared to placebo [PMID:25251930]
Sécurité et effets indésirables
A systematic review of 19 RCTs analyzed adverse event incidence to assess safety in patients with acute high altitude disease [PMID:40584626].
Synthèse des preuves
Evidence is strongest (Level A) for the treatment of acute high altitude disease via systematic review and meta-analysis. Other findings are primarily based on animal models (rats/mice) and in vitro cell lines (Level D), demonstrating potential for treating diabetic kidney disease, NAFLD, and neurodegenerative conditions.
Sources PubMed
1.PMID: 38503156 (2024) — Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. · Phytomedicine : international journal of phytotherapy and phytopharmacology
2.PMID: 36610162 (2023) — Salidroside intensifies mitochondrial function of CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 40504978 (2025) — Mechanistic insights of Rhodiola crenulata in treating diabetic kidney disease via network pharmacology. · Journal of molecular endocrinology
4.PMID: 40584626 (2025) — Efficacy and safety of Rhodiola crenulata extract in the treatment of acute high altitude disease, based on studies involving populations in China: A systematic review and meta-analysis. · Frontiers in pharmacology
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Immunmodulatory and Antiproliferative Properties of Rhodiola Species.
· Planta medica
6.PMID: 37955364 (2023) — Field Collection and Laboratory Routine Identification of Rhodiola crenulata. · Journal of visualized experiments : JoVE
7.PMID: 40699724 (2025) — Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Network Pharmacology Reveal the Mechanisms of Rhodiola crenulata in Improving Non-Alcoholic Fatty Liver Disease. · Current issues in molecular biology
8.PMID: 40354296 (2025) — Mechanistic Insights into Salidroside's Mitochondrial Protection via AMPK/Sirt1/HIF-1α Pathway in Hypoxic HT22 Cells. · Journal of visualized experiments : JoVE
9.PMID: 32138536 (2020) — Neuroprotective Effect of Rhodiola crenulata in D-Galactose-Induced Aging Model. · The American journal of Chinese medicine
10.PMID: 42096998 (2026) — Rhodiosin promotes cerebral angiogenesis in mice with ischemic stroke via PI3K/Akt pathway activation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
11.PMID: 38794164 (2024) — Pharmacokinetic-Pharmacodynamic Correlation Analysis of Rhodiola crenulata in Rats with Myocardial Ischemia. · Pharmaceuticals (Basel, Switzerland)
12.PMID: 28830211 (2017) — Rhodiola crenulata Attenuates High Glucose Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. · The American journal of Chinese medicine
13.PMID: 29871587 (2018) — Evaluation of Rhodiola crenulata on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line. · Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
14.PMID: 40850654 (2026) — Rhodiola crenulata extract inhibits cell pyroptosis to ameliorate pulmonary vascular remodeling in rats through the regulation of decadienylcarnitine/NLRP3/GSDMD axis. · Journal of ethnopharmacology
15.PMID: 35526732 (2022) — Chemical characteristics of Rhodiola Crenulata and its mechanism in acute mountain sickness using UHPLC-Q-TOF-MS/MS combined with network pharmacology analysis. · Journal of ethnopharmacology
16.PMID: 38615983 (2024) — Overexpression of Rhodiola crenulata glutathione peroxidase 5 increases cold tolerance and enhances the pharmaceutical value of the hairy roots. · Gene
17.PMID: 35432456 (2022) — Genome-wide Identification and Expression Analysis of RcMYB Genes in Rhodiola crenulata. · Frontiers in genetics
18.PMID: 31931595 (2020) — Rhodiola crenulata Suppresses High Glucose-Induced Matrix Metalloproteinase Expression and Inflammatory Responses by Inhibiting ROS-Related HMGB1-TLR4 Signaling in Endothelial Cells. · The American journal of Chinese medicine
19.PMID: 34306163 (2021) — Quality Evaluation of Randomized Controlled Trials of Rhodiola Species: A Systematic Review. · Evidence-based complementary and alternative medicine : eCAM
20.PMID: 25251930 (2014) — Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training. · High altitude medicine & biology
21.PMID: 25998182 (2015) — Rhodiola crenulata inhibits Wnt/β-catenin signaling in glioblastoma. · The Journal of surgical research
22.PMID: 41936838 (2026) — Research progress from traditional medicine to chemical composition, pharmacological activity, and clinical application of Rhodiola crenulata. · Journal of ethnopharmacology
23.PMID: 32855685 (2020) — Rhodiola Crenulata ameliorates exhaustive exercise-induced fatigue in mice by suppressing mitophagy in skeletal muscle. · Experimental and therapeutic medicine
24.PMID: 41226160 (2025) — Inhibition Profiling of Rhodiola crenulata on Lactate Dehydrogenase Isoenzymes. · Molecules (Basel, Switzerland)
25.PMID: 25925970 (2015) — Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
26.PMID: 16837437 (2006) — Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. · Asia Pacific journal of clinical nutrition
27.PMID: 31012483 (2019) — Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions. · The Cochrane database of systematic reviews
28.PMID: 37089935 (2023) — Efficacy and safety of three species of Rhodiola L. in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. · Frontiers in pharmacology
29.PMID: 23710233 (2013) — Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats. · Evidence-based complementary and alternative medicine : eCAM