How does Glechoma hederacea work for respiratory conditions?

Glechoma hederacea exerts its effects through active compounds like rosmarinic acid, saponins, and terpenes. Rosmarinic acid provides anti-inflammatory and antioxidant properties, helping to soothe irritated mucous membranes. The saponins are believed to act as expectorants, facilitating the clearance of mucus from the respiratory tract. While these mechanisms are pharmacologically plausible, specific clinical trials confirming these effects in humans are limited (Evidence Level: C/Traditional).

Does ground ivy interact with any prescription medications?

There is limited clinical data regarding specific drug interactions for Glechoma hederacea. However, due to its traditional use as a diuretic and its effects on the kidneys, it may theoretically potentiate the effects of diuretic drugs or interfere with medications processed by the kidneys. Because it contains compounds that can irritate the stomach, it may also affect the absorption of oral medications. Patients taking prescription drugs should consult a healthcare provider before use (Evidence Level: D).

Is ground ivy safe to take during pregnancy?

No, Glechoma hederacea is considered unsafe during pregnancy. Traditional usage and safety classifications indicate that it may stimulate uterine contractions or cause fetal distress. Due to the potential for adverse effects on the pregnancy and a lack of safety data, pregnant women should strictly avoid consuming this herb. It is also contraindicated during breastfeeding (Evidence Level: D/Traditional).

What is the recommended dosage for Glechoma hederacea tea?

The standard adult dosage for Glechoma hederacea tea is 1 to 2 teaspoons of the dried aerial parts per cup of boiling water. This infusion is typically taken up to three times per day. Users should not exceed this recommended dosage without professional guidance, as higher doses may increase the risk of adverse effects (Evidence Level: Traditional).

Can you take ground ivy if you have epilepsy?

No, individuals with epilepsy should not take Glechoma hederacea. The herb is contraindicated for those with seizure disorders because it may lower the seizure threshold, potentially triggering a seizure. This risk is likely due to specific chemical constituents affecting the nervous system. Patients with epilepsy should seek alternative remedies for respiratory issues (Evidence Level: D).

Glechoma hederacea (Glechoma hederacea)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Glechoma hederacea, commonly known as ground ivy, is an aromatic perennial plant used in folk medicine for its anti-inflammatory, antibacterial, and hepatoprotective properties [PMID:35336701, 42173111].

Contexte

Glechoma hederacea (ground ivy or gill-over-the-ground) is a member of the Lamiaceae family [PMID: 24850617, 35742016]. It is distributed across Europe and eastern Asia [PMID: 27870903].

Usages traditionnels

Traditionally used in folk medicine to treat inflammatory disorders [PMID: 24850617], asthma, bronchitis, cholelithiasis, colds, and inflammation [PMID: 35651699]. In traditional Chinese medicine, it is prescribed for cholelithiasis, dropsy, abscess, diabetes, inflammation, and jaundice [PMID: 28416441]. It is also used for gastrointestinal disorders, liver/bile diseases, respiratory ailments, and skin disorders [PMID: 42173111].

Composés actifs

Main bioactive components include polyphenolic compounds such as rosmarinic acid, chlorogenic acid, caffeic acid, and ferulic acid [PMID: 38069297, 35336701, 31152813]. Other identified compounds include flavonoids (rutin, apigenin, luteolin), pentacyclic triterpenes (ursolic acid, oleanolic acid) [PMID: 33450770, 31362424, 24477256], and various terpenoids including sesquiterpene and diterpene glycosides [PMID: 35651699].

Mécanisme d'action

Glechoma hederacea ethanol extract suppresses RANKL-mediated osteoclastogenesis by abrogating free cytosolic Ca(2+) oscillations [PMID: 24850617]. It exhibits antioxidant activity by reducing reactive oxygen species (ROS) and preventing DNA damage in macrophages [PMID: 38069297, 31152813]. Certain flavonoids (apigenin and luteolin) act as xanthine oxidase inhibitors [PMID: 24477256].

Preuves cliniques

Preuve DCholestatic liver injury

Hot water extracts showed protective effects against cholestatic liver injury in a bile duct-ligated rat model, improving serum biochemicals and reducing oxidative stress [PMID: 28416441]

Preuve DGallstone formation

Extract (Hitrechol®) was evaluated for its protective effect against gallstone development in rodent models [PMID: 34261 la71]

Preuve DS. aureus infected skin wounds

A 5% methanolic extract hydrogel showed significant wound healing potential in a rat model [PMID: 35942893]

Preuve DOsteoclastogenesis

Ethanol extract markedly suppressed multi-nucleated cell formation, TRAP activity, and NFATc1 expression in bone marrow-derived macrophages [PMID: 24850617]

Sécurité et effets indésirables

General toxicity was assessed using the brine shrimp lethality assay [PMID: 12490241], but specific adverse effects in humans are not detailed in the provided abstracts.

Synthèse des preuves

The current evidence is primarily based on in vitro cell line studies and in vivo rodent models (Level D), demonstrating significant antioxidant, anti-inflammatory, and hepatoprotective potential.

Sources PubMed

1.PMID: 24850617 (2014) — Glechoma hederacea Suppresses RANKL-mediated Osteoclastogenesis. · Journal of dental research
2.PMID: 38069297 (2023) — Studying the Functional Potential of Ground Ivy (Glechoma hederacea L.) Extract Using an In Vitro Methodology. · International journal of molecular sciences
3.PMID: 35651699 (2022) — Terpenoids from Glechoma hederacea var. longituba and their biological activities. · Beilstein journal of organic chemistry
4.PMID: 33450770 (2021) — Simultaneous Quantification of Ursolic and Oleanolic Acids in Glechoma hederacea and Glechoma hirsuta by UPLC/MS/MS. · Planta medica
5.PMID: 12490241 (2002) — Biological activity of Glechoma hederacea.

Glechoma hederacea

Sources et citations

Kumarahou

Speedwell Herb

Allium Cepa Herb

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Glechoma hederacea

Sources et citations

Plantes associées

Kumarahou

Speedwell Herb

Allium Cepa Herb

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales