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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Gleditsia japonica
Japanese honeylocust; pods used in Japanese folk medicine as expectorant and anti-inflammatory.
Gleditsia japonica, commonly known as Japanese honeylocust, is a medicinal plant whose pods are traditionally used in Japanese folk medicine as an expectorant and anti-inflammatory agent. Modern research indicates potential applications for cough with phlegm, skin diseases, and constipation, attributed to its content of saponins, flavonoids, alkaloids, and tannins. However, clinical evidence remains limited (Level C), and safety concerns include gastrointestinal irritation and uterine stimulation.
The expectorant action is primarily mediated by triterpenoid saponins (e.g., gleditsiosides) that reduce mucus viscosity and enhance mucociliary clearance via activation of airway epithelial chloride channels. Anti-inflammatory effects involve inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) pathways, reducing prostaglandin and leukotriene synthesis, as well as suppression of NF-κB signaling by flavonoids. The laxative effect is attributed to saponin-induced irritation of intestinal mucosa, stimulating peristalsis, while alkaloids may contribute to uterine smooth muscle contraction.
Japanese honeylocust; pods used in Japanese folk medicine as expectorant and anti-inflammatory.
Gleditsia japonica, commonly known as Japanese honeylocust, is a medicinal plant whose pods are traditionally used in Japanese folk medicine as an expectorant and anti-inflammatory agent. Modern research indicates potential applications for cough with phlegm, skin diseases, and constipation, attributed to its content of saponins, flavonoids, alkaloids, and tannins. However, clinical evidence remains limited (Level C), and safety concerns include gastrointestinal irritation and uterine stimulation.
The expectorant action is primarily mediated by triterpenoid saponins (e.g., gleditsiosides) that reduce mucus viscosity and enhance mucociliary clearance via activation of airway epithelial chloride channels. Anti-inflammatory effects involve inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) pathways, reducing prostaglandin and leukotriene synthesis, as well as suppression of NF-κB signaling by flavonoids. The laxative effect is attributed to saponin-induced irritation of intestinal mucosa, stimulating peristalsis, while alkaloids may contribute to uterine smooth muscle contraction.