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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Hyssopus officinalis is an aromatic medicinal herb used traditionally for respiratory and gastrointestinal ailments [PMID:31643710, PMID:36503515].
Contexte
Hyssop is a perennial subshrub of the Lamiaceae family distributed from the eastern Mediterranean region to central Asia [PMID:31643710, PMID:34746475]. It is an aromatic plant containing essential oils and is used as a spice, ornamental plant, and in various cosmetic and food applications [PMID:41681651].
Usages traditionnels
It is used for the alleviation of symptoms associated with the common cold, respiratory tract infections, gastrointestinal infections, loss of appetite, fungal infections, and spasmodic conditions [PMID:31643710, PMID:35069979]. It has also been used in traditional medicine to treat seizures [PMID:36287300].
Composés actifs
The herb is rich in phenolic compounds, flavonoids (including luteolin, quercetin, apigenin, and diosmin), and rosmarinic and chlorogenic acids [PMID:35069979, PMID:34746475, PMID:35358622]. Its essential oil contains oxygenated terpene compounds, primarily monoterpene ketones such as cis-pinocamphone and isopinocamphone, as well as beta-pinene and eucalyptol [PMID:41681651, PMID:35069979, PMID:39367824].
Mécanisme d'action
Hyssop extracts have demonstrated the ability to inhibit alpha-glucosidase activity, thereby reducing intestinal carbohydrate absorption and postprandial hyperglycemia [PMID:14703310, PMID:14697274]. Methanol extracts have shown inhibitory activity against the COX-2 enzyme [PMID:35358622]. Additionally, crude extracts have shown anti-HIV activity by inhibiting reverse transcriptase (RT), syncytia formation, and p17/p24 antigen expression [PMID:1708226].
Preuves cliniques
Preuve BMild to Moderate Asthma
Patients with productive cough receiving hyssop syrup (5 ml twice daily) showed significant improvement in FEV1, Asthma Control Test (ACT) scores, and peak expiratory flow (PEF) over 4 weeks [PMID:39959798]
Sécurité et effets indésirables
Hyssop has not been implicated in causing liver injury [PMID:31643710]. However, commercial hyssop essential oils have been reported to cause human intoxication characterized by tonic-clonic convulsions [PMID:7333081]. Experimental data in rats indicate that hyssop oil can induce electrocortical clonic seizures and may have cumulative toxic effects with repeated subclinical doses [PMID:7333081].
Synthèse des preuves
Evidence consists primarily of in vitro studies, animal models (rats, fish), and one randomized clinical trial for asthma. While traditional use is widespread, safety concerns exist specifically regarding the concentrated essential oil.
Sources PubMed
1.PMID: 31643710 (2012) — The Genus Hyssopus: Traditional Use, Phytochemicals and Pharmacological Properties. · Plants (Basel, Switzerland)
2.PMID: 39959798 (2024) — Effect of Hyssop (Hyssopus officinalis) Syrup on Mild to Moderate Asthma: A Randomized Double-Blind Placebo-Controlled Trial. · Tanaffos
3.PMID: 36503515 (2022) — The impact of Hyssop (Hyssopus officinalis) extract on activation of endosomal toll like receptors and their downstream signaling pathways. · BMC research notes
4.PMID: 35617511 (2023) — Chemical compositions, yield and antioxidant activity of the essential oil of hyssop (Hyssopus officinalis L.) under intercropping with fenugreek (Trigonella foenum-graecum L.). · Natural product research
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Ontogenetic and Environmental Variability of Hyssop (Hyssopus officinalis L.) Essential Oil Composition and Activity.
· Plants (Basel, Switzerland)
6.PMID: 14703310 (2003) — Inhibitory effects of hyssop (Hyssopus officinalis) extracts on intestinal alpha-glucosidase activity and postprandial hyperglycemia. · Journal of nutritional science and vitaminology
7.PMID: 36740126 (2023) — Effect of ultrasound-assisted cold plasma pretreatment on cell wall polysaccharides distribution and extraction of phenolic compounds from hyssop (Hyssopus officinalis L.). · International journal of biological macromolecules
8.PMID: 39519905 (2024) — Comparative Study on the Response of Hyssop (Hyssopus officinalis L.), Salvia (Salvia officinalis L.), and Oregano (Origanum vulgare L.) to Drought Stress Under Foliar Application of Selenium. · Plants (Basel, Switzerland)
9.PMID: 35069979 (2022) — Hyssopus Essential Oil: An Update of Its Phytochemistry, Biological Activities, and Safety Profile. · Oxidative medicine and cellular longevity
10.PMID: 14697274 (2004) — Isolation of alpha-glusosidase inhibitors from hyssop (Hyssopus officinalis). · Phytochemistry
11.PMID: 38931043 (2024) — Green Synthesis of Silver Nanoparticles with Hyssopus officinalis and Salvia officinalis Extracts, Their Properties, and Antifungal Activity on Fusarium spp. · Plants (Basel, Switzerland)
12.PMID: 32659662 (2020) — Effects of exogenous application of citrulline on prolonged water stress damages in hyssop (Hyssopus officinalis L.): Antioxidant activity, biochemical indices, and essential oils profile. · Food chemistry
13.PMID: 36287300 (2022) — Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat. · Neurochemical research
14.PMID: 39253917 (2024) — Phytochemical Profile and Antioxidant and Protective Activities of Various Types of Extracts from Hyssopus officinalis L. and Grindelia robusta Nutt. Herb Grown in Poland. · Current topics in medicinal chemistry
15.PMID: 39367824 (2025) — Study of Hyssop Essential Oil from Southeastern Serbia. · Chemistry & biodiversity
16.PMID: 35963984 (2022) — The Effects of Methanol Extracts of Hyssopus officinalis on Model of Induced Glioblastoma Multiforme (GBM) in Rats. · Journal of molecular neuroscience : MN
17.PMID: 31775790 (2019) — Medicinal plants of the Bible-revisited. · Journal of ethnobiology and ethnomedicine
18.PMID: 37562266 (2024) — Fabrication of double nano-emulsions loaded with hyssop (Hyssopus officinalis L.) extract stabilized with soy protein isolate alone and combined with chia seed gum in controlling the oxidative stability of canola oil. · Food chemistry
19.PMID: 32148832 (2020) — The effect of encapsulated plant extract of hyssop (Hyssopus officinalis L.) in biopolymer nanoemulsions of Lepidium perfoliatum and Orchis mascula on controlling oxidative stability of soybean oil. · Food science & nutrition
20.PMID: 36337198 (2022) — Effects of dietary Hyssop, Hyssopus officinalis, extract on physiological and antioxidant responses of rainbow trout, Oncorhynchus mykiss, juveniles to thermal stress. · Frontiers in veterinary science
21.PMID: 7333081 (1981) — Toxicity of some essential plant oils. Clinical and experimental study. · Clinical toxicology
22.PMID: 34746475 (2021) — Qualitative and quantitative analysis of diosmin content of hyssop (Hyssopus officinalis) in response to salinity stress. · Heliyon
23.PMID: 33297565 (2020) — Potential Use of Hyssopus officinalis and Borago officinalis as Curing Ingredients in Pork Meat Formulations. · Animals : an open access journal from MDPI
24.PMID: 32573004 (2020) — Ameliorative Effects of a Static Magnetic Field on Hyssop (Hyssopus officinalis L.) Growth and Phytochemical Traits Under Water Stress. · Bioelectromagnetics
25.PMID: 35358622 (2022) — In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae). · Journal of ethnopharmacology
26.PMID: 1708226 (1990) — Inhibition of HIV replication by Hyssop officinalis extracts. · Antiviral research
27.PMID: 38611526 (2024) — Application of Common Culinary Herbs for the Development of Bioactive Materials. · Plants (Basel, Switzerland)