What is Piper sarmentosum in English?

Piper sarmentosum (Piper sarmentosum) is known in English as Wild Betel, Kaduk, Cha Phlu. It is traditionally used for digestive disorders, malaria, cough.

Is Piper sarmentosum safe during pregnancy?

Piper sarmentosum is generally considered safe during pregnancy, but always consult your healthcare provider.

Does Piper sarmentosum interact with medications?

Piper sarmentosum has no well-documented major drug interactions in our database, but always inform your healthcare provider about all supplements you take.

What are the side effects of Piper sarmentosum?

Recommended adult dosage: 10–30 g fresh leaves or 3–6 g dried leaves daily, preferably with food.. Generally safe at food doses; mild gastrointestinal upset possible with excessive intake.. Avoid large doses during pregnancy despite traditional safe use; high doses may stimulate uterine contractions.

How do I calculate a safe dose of Piper sarmentosum?

Use HerbAlly's free herbal dosage calculator — enter the adult reference dose for Piper sarmentosum, plus age and weight, to get a Clark's / Young's rule pediatric estimate. Never exceed the adult dose.

Piper sarmentosum (Piper sarmentosum): Benefits, Dosage, Safety & Evidence

PubMed-compiled information sheet

This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.

Compiled from 30 PubMed articles · model: gemma4:31b

Summary

Piper sarmentosum is a traditional Southeast Asian medicinal and culinary plant with demonstrated antioxidant and anti-inflammatory properties [PMID:36453484, PMID:24107234].

Background

Piper sarmentosum Roxb. (Piperaceae) is an edible medicinal plant widely distributed in India, Malaysia, Thailand, and southeastern coastal areas of China [PMID:32620264, PMID:36091787].

Traditional uses

It has been used for centuries to treat wind-cold cough, fever, rheumatism arthralgia, diarrhea dysentery, postpartum foot swelling, stomachache, toothache, diabetes, traumatic injury, inflammation, dermatitis, joint pain, hypertension, and gastric ailments [PMID:32620264, PMID:24107234, PMID:36091787, PMID:40882786].

Active compounds

Identified compounds include flavonoids such as naringenin [PMID:24107234], amide alkaloids (including pipersarmenoids A-F, pellitorine, and sarmentine) [PMID:38906388], and oroxylin A [PMID:37755961]. Other metabolites include lignans, phenylpropanoids, and aporphines [PMID:38743199].

Mechanism of action

The herb exhibits antioxidant and anti-inflammatory activities [PMID:36453484]. It may protect bone by acting as a superoxide scavenger via naringenin [PMID:24107234] and inhibit the Angiotensin-Converting Enzyme (ACE) pathway to exert antihypertensive effects [PMID:38474055]. Pellitorine may alleviate cognitive deficits by inhibiting neural inflammation and ferroptosis [PMID:40609205].

Clinical evidence

Evidence COsteoporosis and Fracture Healing

Prevented deterioration of bone histomorphometric indices and promoted fracture healing in animal models of osteoporosis induced by ovariectomy and glucocorticoids [PMID:36453484, PMID:21789393].

Evidence AHypertension and Diabetes Mellitus

Traditionally used for these conditions; systematic review and meta-analysis conducted to evaluate effects [PMID:36091787].

Evidence DStress-Induced Gastric Ulcers

Methanolic extract (500 mg/kg) was as effective as omeprazole in preventing gastric lesions in rats by modulating oxidative stress and inflammation [PMID:36712695, PMID:30697274].

Evidence DVascular Endothelial Dysfunction

Aqueous leaf extract (250 mg/kg/day) improved vasorelaxation and vascular nitric oxide levels in nicotine-induced rats [PMID:34194328].

Evidence DCognitive Deficits (CRS)

Pellitorine treatment significantly alleviated depression-like behaviors and improved cognitive function in chronic restraint stress mouse models [PMID:40609205].

Evidence summary

The majority of evidence is derived from animal models, in vitro studies, and literature reviews. While there is a systematic review/meta-analysis regarding hypertension and diabetes, most specific therapeutic claims are supported by preclinical data (Level C and D).

PubMed sources

1.PMID: 36453484 (2023) — Effects of Piper sarmentosum on Bone Health and Fracture Healing: A Scoping Review. · Endocrine, metabolic & immune disorders drug targets
2.PMID: 24107234 (2013) — Piper sarmentosum: a new hope for the treatment of osteoporosis. · Current drug targets
3.PMID: 36091787 (2022) — Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis. · Frontiers in pharmacology
4.PMID: 32620264 (2020) — Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. · Journal of ethnopharmacology
5.PMID: 38906388 (2024) — Pipersarmenoids, new amide alkaloids from Piper sarmentosum. · Fitoterapia

Piper sarmentosum

Sources & Citations

Calculate a safe dose of Piper sarmentosum

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Frequently asked questions

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Evidence summary

PubMed sources

Government sources

Piper sarmentosum

Sources & Citations

Calculate a safe dose of Piper sarmentosum

Related Herbs

Salvia pratensis

Picao Preto

Leptospermum Scoparium

Frequently asked questions

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Evidence summary

PubMed sources

Government sources