PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Prevented deterioration of bone histomorphometric indices and promoted fracture healing in animal models of osteoporosis induced by ovariectomy and glucocorticoids [PMID:36453484, PMID:21789393].
Traditionally used for these conditions; systematic review and meta-analysis conducted to evaluate effects [PMID:36091787].
Methanolic extract (500 mg/kg) was as effective as omeprazole in preventing gastric lesions in rats by modulating oxidative stress and inflammation [PMID:36712695, PMID:30697274].
Aqueous leaf extract (250 mg/kg/day) improved vasorelaxation and vascular nitric oxide levels in nicotine-induced rats [PMID:34194328].
Pellitorine treatment significantly alleviated depression-like behaviors and improved cognitive function in chronic restraint stress mouse models [PMID:40609205].
Evidence summary
PubMed sources
- 1.PMID: 36453484 (2023) — Effects of Piper sarmentosum on Bone Health and Fracture Healing: A Scoping Review. · Endocrine, metabolic & immune disorders drug targets
- 2.PMID: 24107234 (2013) — Piper sarmentosum: a new hope for the treatment of osteoporosis. · Current drug targets
- 3.PMID: 36091787 (2022) — Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis. · Frontiers in pharmacology
- 4.PMID: 32620264 (2020) — Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. · Journal of ethnopharmacology
- 5.PMID: 38906388 (2024) — Pipersarmenoids, new amide alkaloids from Piper sarmentosum.