PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 26 PubMed articles · model: gemma4:31b
Summary
Salvia pratensis is a common meadow plant found in temperate zones worldwide [PMID:39753866], which has been investigated for its antioxidant, anti-cancer, and neuroprotective properties [PMID:41929771, PMID:41436290, PMID:36771054].
Background
Salvia pratensis L. is a gynodioecious, protandrous perennial member of the Lamiaceae family [PMID:28564294, PMID:31455268]. It is widely distributed in temperate zones and is often used as an adulterant or substitute for Salvia officinalis (sage) [PMID:39753866, PMID:30000875, PMID:19104481].
Traditional uses
It is sometimes used in traditional medicine as a substitute for sage (Salvia officinalis) [PMID:19104481].
Active compounds
The plant contains phenolic compounds, including hydroxycinnamic acids (caffeic, p-coumaric, and ferulic acids) [PMID:41977699], and flavonoids [PMID:39753866, PMID:36771054]. Its essential oil is characterized by E-caryophyllene (26.4%) and a linalool-rich profile with sesquiterpene derivatives [PMID:19104481, PMID:41977699]. Other identified components include abietane diterpenoids in the roots [PMID:17253248] and the phenylpropanoid glycoside acteoside [PMID:41436290].
Mechanism of action
Extracts of S. pratensis exhibit inhibitory activity against the amyloid aggregation of α-synuclein in vitro and in neuroblastoma cells [PMID:41436290]. In triple-negative breast cancer cells, it exhibits anti-cancer effects through miR-34a-5p signaling [PMID:41929771].
Clinical evidence
Evidence DParkinson's Disease (In Vitro/Cell Models)
Extracts exhibit robust inhibitory activity against the amyloid aggregation of α-synuclein [PMID:41436290]
Evidence DTriple-Negative Breast Cancer (In Vitro)
Leaf extracts exhibit anti-cancer effects via miR-34a-5p signaling [PMID:41929771]
Evidence DFungal Infection (Rhizopus stolonifer)
Non-polar herbal extracts caused high inhibition of Rhizopus growth [PMID:17912643]
Evidence summary
The current evidence is primarily based on in vitro studies, phytochemical profiling, and botanical research (Level D). There are no human clinical trials provided in the abstracts.
PubMed sources
- 1.PMID: 30000875 (2006) — Development of 18 microsatellite markers for Salvia pratensis. · Applications in plant sciences
- 2.PMID: 41436290 (2026) — Acteoside exerts neuroprotective effects by preventing α-synuclein aggregation and oxidative stress in models of Parkinson's disease. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
- 3.PMID: 39753866 (2025) — Salvia pratensis L. extracts as potential eco-friendly herbicides for sustainable agricultural applications. · Scientific reports
- 4.PMID: 36771054 (2023) — Biosynthesis of Silver Nanoparticles Using Salvia pratensis L. Aerial Part and Root Extracts: Bioactivity, Biocompatibility, and Catalytic Potential. · Molecules (Basel, Switzerland)
- 5.PMID: 19104481 (2008) — Chemical composition of essential oil and leaf anatomy of Salvia bertolonii Vis. and Salvia pratensis L. (Sect. Plethiosphace, Lamiaceae).