Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Kalonji seeds contain thymoquinone as their primary active compound, which provides anti-inflammatory and antioxidant effects. Thymoquinone modulates immune cell activity, reduces inflammatory cytokines, and may improve insulin sensitivity. The seeds also contain thymol and carvacrol, which contribute to antimicrobial and bronchodilatory effects. These compounds work synergistically to support respiratory health and metabolic function. Evidence Level: C.
Does kalonji interact with any medications?
Yes, kalonji seeds may interact with several medications. Due to their blood sugar-lowering effects, they can enhance the action of diabetes medications, potentially causing hypoglycemia. The seeds may increase bleeding risk when combined with anticoagulants or antiplatelet drugs such as warfarin or aspirin. Additionally, kalonji may lower blood pressure and amplify the effects of antihypertensive medications. Patients taking these medications should consult a healthcare provider before use. Evidence Level: C.
What is the recommended dosage of kalonji seeds for adults?
The typical adult dosage is 1 teaspoon of whole seeds daily, or 500mg of standardized extract taken twice daily. Seeds can be consumed whole, crushed, or brewed as a tea. For metabolic support, consistent daily use over 8-12 weeks may be needed to observe benefits. Start with lower doses to assess tolerance, and always follow product-specific recommendations from reputable manufacturers. Evidence Level: C, Traditional.
Is kalonji seed safe during pregnancy?
Kalonji seeds are considered unsafe during pregnancy, particularly at therapeutic doses. Traditional use and preliminary research suggest the seeds may stimulate uterine contractions and potentially affect pregnancy outcomes. Small culinary amounts used as a spice in food are generally considered acceptable, but medicinal doses should be avoided entirely. Women who are pregnant or planning pregnancy should consult a qualified healthcare practitioner before using kalonji supplements. Evidence Level: C, Traditional.
What are the health benefits of kalonji seeds?
Kalonji seeds have been used traditionally in Indian Unani and Ayurvedic medicine as an immune tonic and respiratory remedy. Modern research suggests potential benefits for blood sugar regulation in type 2 diabetes, blood pressure management, and reducing systemic inflammation. The seeds may also support respiratory health in conditions like asthma due to their bronchodilatory properties. While promising, most evidence comes from preliminary studies, and more rigorous clinical trials are needed. Evidence Level: C, Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Nigella sativa (Kalonji) is a medicinal seed used globally for its anti-inflammatory, antioxidant, and antimicrobial properties [PMID:33281391, PMID:38016656].
Contexte
Nigella sativa, also known as black seed, black cumin, or Kalonji, is a member of the Ranunculaceae family [PMID:28195061, PMID:32020890]. It is widely used as both a food ingredient and a complementary drug in various traditional medicine systems, including Unani and Ayurveda [PMID:19500003, PMID:31799702].
Usages traditionnels
Traditionally used for the treatment of several medical disorders including dyslipidemia, obesity, hypertension [PMID:19500003], diarrhea, and asthma [PMID:11381824]. It has also been used orally as a galactogogue in India, Türkiye, and the Middle East [PMID:30000936].
Composés actifs
The seeds contain essential and fixed oils featuring thymoquinone, beta-elemene, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellicine, nigellimine, nigellidine, and alpha-hederin [PMID:30000936, PMID:29358959]. Phytosterols such as spinasterol and schottenol are also identified in the seed oil [PMID:38036874].
Mécanisme d'action
Nigella sativa exhibits calcium antagonist activity, acting as a calcium channel blocker to produce bronchodilator and spasmolytic effects [PMID:11381824]. It also demonstrates anti-proliferative and apoptotic activity against certain cancer cell lines [PMID:31433749, PMID:32020890].
Preuves cliniques
Preuve DHyperlipidemia
Nigella sativa showed significant improvement in the lipid profile of rats, comparable to the effects of simvastatin [PMID:25730783].
Preuve BGingivitis
Ethanolic solutions of N. sativa were explored for clinical efficacy in moderate-to-severe gingivitis patients [PMID:33281391].
A randomized, double-blind trial evaluated the effectiveness of powdered N. sativa in capsules on these parameters in adults [PMID:19500003].
Preuve CLong COVID
N. sativa has shown potential anti-inflammatory, antioxidant, and immunomodulatory properties that may help mitigate Long COVID symptoms [PMID:36825730].
Preuve CHepatitis B and C
Preclinical and clinical investigations suggest N. sativa may be effective against HBV and HCV infections [PMID:39980283].
Sécurité et effets indésirables
Nigella sativa is generally well tolerated, although the oil can cause allergic contact dermatitis [PMID:30000936]. One historical report mentions fatal poisoning by Nigella seed [PMID:13193171].
Grossesse et allaitement
Used as galactogogues, but no scientifically valid clinical trials support this use in humans; one study showed a slight increase in serum prolactin but no evidence of growth promotion in infants [PMID:30000936]. No data exist on excretion into breastmilk or safety in infants [PMID:30000936].
Synthèse des preuves
Evidence ranges from laboratory animal studies (D) and narrative reviews (C) to randomized controlled trials (B). While preclinical data strongly support anti-inflammatory and lipid-lowering effects, high-level clinical evidence for specific human therapeutic doses is limited.
Sources PubMed
1.PMID: 30000936 (2006) — Effects of Active Compounds of Nigella sativa in COVID-19: A Narrative Review. · Recent advances in anti-infective drug discovery
2.PMID: 36825730 (2023) — Potential of Black Seeds (Nigella sativa) in the Management of Long COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent COVID-19 Symptoms - An Insight. · Infectious disorders drug targets
3.PMID: 25730783 (2015) — Comparative evaluation of Nigella sativa (Kalonji) and simvastatin for the treatment of hyperlipidemia and in the induction of hepatotoxicity. · Pakistan journal of pharmaceutical sciences
4.PMID: 33281391 (2019) — An evaluation of the efficacy of ethanolic extract of Nigella sativa L. (Kalonji) on the clinical parameters of moderate‑to‑severe gingivitis: A split‑mouth clinical study. · Ayu
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Nigella Sativa (Black Seeds), A Potential Herb for the Pharmacotherapeutic Management of Hypertension - A Review.
· Current cardiology reviews
6.PMID: 19500003 (2009) — Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. · Journal of alternative and complementary medicine (New York, N.Y.)
7.PMID: 38016656 (2024) — Dermaceutical Utilization of Nigella sativa Seeds: Applications and Opportunities. · Drug research
8.PMID: 31433749 (2019) — In-Vitro Anti-Proliferative, Apoptotic and Antioxidative Activities of Medicinal Herb Kalonji (Nigella sativa). · Current pharmaceutical biotechnology
9.PMID: 38036874 (2024) — Chemical and Biochemical Features of Spinasterol and Schottenol. · Advances in experimental medicine and biology
10.PMID: 29358959 (2017) — A Review on the Cosmeceutical and External Applications of Nigella sativa. · Journal of tropical medicine
11.PMID: 35056865 (2022) — Biological Potentials and Phytochemical Constituents of Raw and Roasted Nigella arvensis and Nigella sativa. · Molecules (Basel, Switzerland)
12.PMID: 27904549 (2016) — Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review on clinical trials. · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
13.PMID: 16092657 (2005) — Effect of Nigella sativa (kalonji) on serum cholesterol of albino rats. · Journal of Ayub Medical College, Abbottabad : JAMC
14.PMID: 38068725 (2023) — A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome. · Nutrients
15.PMID: 39980283 (2025) — Clinical and In vitro Data Shed New Light on the Therapeutic Advantages of Black Seeds (Nigella sativa) for the Treatment of Hepatitis C and Hepatitis B Viral Infections. · Infectious disorders drug targets
16.PMID: 11381824 (2001) — Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. · JPMA. The Journal of the Pakistan Medical Association
17.PMID: 31799702 (2020) — Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals. · British journal of pharmacology
18.PMID: 30351462 (2018) — Microscopic investigations and pharmacognostic techniques used for the standardization of herbal drug Nigella sativa L. · Microscopy research and technique
19.PMID: 39313886 (2025) — An Overview of Possible Beneficial Effects of Black Seeds (Nigella Sativa) on the Management of "Disease X". · Infectious disorders drug targets
20.PMID: 36826282 (2023) — In Vitro and In Vivo Investigation of a Dual-Targeted Nanoemulsion Gel for the Amelioration of Psoriasis. · Gels (Basel, Switzerland)
21.PMID: 32020890 (2020) — Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line. · BMC complementary medicine and therapies
22.PMID: 28195061 (2016) — Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
23.PMID: 39220943 (2024) — Facile synthesis of ZnO nanoparticles using Nigella Sativa extract and its role as catalyst in production of bio-oil and degradation of methylene blue dye. · Heliyon
24.PMID: 29984327 (2018) — Anxiolytic and anti-inflammatory role of thymoquinone in arsenic-induced hippocampal toxicity in Wistar rats. · Heliyon
25.PMID: 16414763 (1995) — Antifasciolic efficacy of indigenous plant drugs: kalonji, shahterah and karanjwa in buffaloes. · Pakistan journal of pharmaceutical sciences
26.PMID: 34392118 (2022) — Impact of microwave roasting on physicochemical properties, maillard reaction products, antioxidant activity and oxidative stability of nigella seed (Nigella sativa L.) oil. · Food chemistry
27.PMID: 13193171 (1954) — [Fatal poisoning by Nigella seed]. · Maroc medical
28.PMID: 26720998 (2015) — COMPARISON OF ANTI-INFLAMMATORY ACTIVITY OF NIGELLA SATIVA AND DICLOFENAC SODIUM IN ALBINO RATS. · Journal of Ayub Medical College, Abbottabad : JAMC