Ixora coccinea (Ixora coccinea): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Ixora coccinea help with wound healing?

Ixora coccinea contains flavonoids (luteolin, rutin) and tannins that contribute to its wound-healing properties. These compounds exhibit anti-inflammatory and antioxidant activity, which may reduce oxidative stress at wound sites. Tannins provide astringent effects that help contract tissues and reduce bleeding. The plant's antimicrobial properties may also help prevent wound infection. Evidence Level: C (preliminary studies).

Does Ixora coccinea interact with any medications?

There is limited research on Ixora coccinea drug interactions. The tannin content may potentially reduce absorption of certain medications, including iron supplements and some alkaloid drugs. Due to insufficient clinical data, individuals taking prescription medications should consult a healthcare provider before using Ixora coccinea preparations. Evidence Level: C (based on constituent properties, not clinical trials).

What is the recommended dosage of Ixora coccinea?

Traditional preparations use 3-5 grams of dried flowers or leaves brewed as a tea, taken twice daily. For topical applications, a paste made from crushed fresh leaves or flowers can be applied directly to affected skin areas. Standardized extracts lack established dosing guidelines. Always follow product-specific instructions or consult a qualified herbalist. Evidence Level: Traditional/C.

Is Ixora coccinea safe during pregnancy?

Ixora coccinea is contraindicated during pregnancy. Traditional use includes stimulating menstrual flow, which may pose risks of uterine contraction and potential pregnancy complications. There is insufficient safety data for breastfeeding women. Women who are pregnant, planning pregnancy, or nursing should avoid Ixora coccinea in all forms. Evidence Level: C (based on traditional use and pharmacological properties).

What are the medicinal uses of Ixora coccinea?

Ixora coccinea has been used traditionally for wound healing, skin conditions, fever, diarrhea, and menstrual disorders. The flowers and leaves are the primary parts used medicinally. In South Asian folk medicine, preparations are applied topically for skin ailments or consumed as tea for internal conditions. Current evidence is preliminary (Level C), and more clinical research is needed.

What are the side effects of Ixora coccinea?

Common side effects include gastrointestinal upset and, with excessive use, constipation due to the high tannin content. Individuals with existing constipation should avoid internal use. Allergic reactions are possible with topical application. Discontinue use if adverse symptoms occur and seek medical attention for severe reactions. Evidence Level: C/Traditional.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Ixora coccinea is an evergreen shrub of the Rubiaceae family used in traditional medicine for various ailments, demonstrating antioxidant, antimicrobial, and anticancer properties in experimental models [PMID:22231708, PMID:38562312].

Contexte

Ixora coccinea, also known as jungle geranium or flame of the woods, is a perennial shrub and flowering plant native to Eastern India and found throughout India and other tropical/subtropical regions [PMID:22231708, PMID:38562312, PMID:30754286, PMID:28539719].

Usages traditionnels

In Ayurveda and folk medicine, the flowers, leaves, roots, and stem are used to treat diarrhea, dysentery, fever, headache, skin diseases, eye trouble, wounds, sores, ulcers, hypertension, menstrual irregularities, and sprains [PMID:22231708, PMID:25185927, PMID:24624303, PMID:24704593].

Composés actifs

The plant contains triterpene acids (ursolic acid, oleanolic acid), lupeol, sitosterol, rutin, anthocyanins, proanthocyanidins, glycosides of kaempferol and quercetin, flavonoids, phenols, tannins, alkaloids, and novel bioactive peptides (ixorapeptide I and II) [PMID:22231708, PMID:15214483, PMID:21106454, PMID:38562312].

Mécanisme d'action

The herb exhibits antioxidant activity by scavenging free radicals (DPPH, ABTS, nitric oxide) and restoring catalase and SOD activity [PMID:30333948]. It enhances wound healing by upregulating the expression of collagen type III (COL3A1) and basic fibroblast growth factor (bFGF) [PMID:24624303]. Anti-inflammatory effects are associated with the inhibition of human neutrophil polarization, phagocytic activity, and reactive oxygen species (ROS) production [PMID:24704593].

Preuves cliniques

Preuve DDiarrhea

Aqueous flower extract showed significant inhibitory activity against castor oil-induced diarrhea in rats [PMID:21731376]

Preuve DPain and Inflammation

Ethanol leaf extract significantly increased reaction time in hot-plate tests and inhibited acetic acid-induced writhing and carrageenan-induced paw edema in rodents [PMID:24468614]

Preuve DDepression

Methanol extracts (100-200 mg/kg) significantly reduced immobility duration in tail suspension and forced swim tests in mice [PMID:32454651]

Preuve DCardiac Toxicity

Methanolic leaf extract (200-400 mg/kg) reduced ST segment elevation and maintained blood pressure in doxorubicin-induced cardiac toxicity rat models [PMID:22529471]

Preuve DWound Healing

Methanol leaf extract promoted wound contraction and increased hydroxyproline quantification in rat excision models [PMID:24624303]

Preuve DCancer (In Vitro/Animal)

Synthèse des preuves

The current evidence consists primarily of in vitro studies and animal models (Level D), suggesting broad pharmacological potential, but lacks human clinical trials.

Sources PubMed

1.PMID: 38562312 (2024) — In Vitro Evaluation of Extracts From Ixora Species for a Potential Phytosomal Formulation. · Cureus
2.PMID: 22231708 (2012) — Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology. · Chinese journal of integrative medicine
3.PMID: 30333948 (2018) — Amelioration of arsenic-induced oxidative stress in CHO cells by Ixora coccinea flower extract. · 3 Biotech
4.PMID: 38800336 (2024) — In Vitro Wound Healing and Anticancer Effects of Ixora coccinea in Malignant Melanoma Cell Lines. · Cureus
5.PMID: 21731376 (2010) — Antidiarrheal activity of flowers of Ixora Coccinea Linn. in rats. · Journal of Ayurveda and integrative medicine

Ixora coccinea

Sources et citations

Calculer une dose sûre de Ixora coccinea

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Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Ixora coccinea

Sources et citations

Calculer une dose sûre de Ixora coccinea

Plantes associées

Psidium Guineense

Kaempferia rotunda

Alnus glutinosa

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales