How does Javanese turmeric work for liver health?

Javanese turmeric works primarily through xanthorrhizol, a potent active compound that exhibits hepatoprotective properties. It stimulates bile production and secretion, a process known as a choleretic effect, which aids digestion and liver detoxification. Evidence Level A research indicates that curcuminoids within the herb also reduce inflammation by inhibiting pro-inflammatory cytokines, supporting its traditional use for liver and gallbladder function.

Does Javanese turmeric interact with medications?

Javanese turmeric may interact with medications metabolized by the liver or those affecting blood clotting. Because it stimulates bile flow, it can alter the absorption of certain drugs. Individuals taking anticoagulants or antiplatelet drugs should exercise caution due to potential additive effects. Always consult a healthcare provider before combining this herbal supplement with prescription medications.

What is the recommended dosage for Javanese turmeric?

The standard adult dosage for Javanese turmeric is 250-500mg of a standardized extract taken daily. Alternatively, one can consume approximately 2g of the dried rhizome prepared as a tea. It is best taken with meals to enhance absorption and reduce potential gastrointestinal upset. Always follow specific product label instructions or professional guidance.

Is Javanese turmeric safe during pregnancy?

No, Javanese turmeric is considered unsafe during pregnancy. It stimulates uterine contractions and increases bile flow, which poses significant risks during gestation. Breastfeeding women should also avoid this herb due to a lack of safety data. It is crucial to consult a doctor before use if pregnant or planning to become pregnant.

Who should not take Javanese turmeric?

Individuals with bile duct obstruction, gallstones, or severe liver disease should avoid Javanese turmeric. Because it actively stimulates bile secretion, use can exacerbate existing blockages or induce gallstone colic. Those with known allergies to the Zingiberaceae family, such as ginger or common turmeric, should also avoid it due to the risk of rare allergic reactions.

Curcuma javanais (Curcuma xanthorrhiza)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Curcuma xanthorrhiza, also known as Javanese turmeric or Temulawak, is a medicinal plant native to Indonesia used for its anti-inflammatory, antioxidant, and antimicrobial properties [PMID:34194529, PMID:38239285].

Contexte

Curcuma xanthorrhiza Roxb. is a member of the Zingiberaceae family originating from Java Island, Indonesia [PMID:37346311, PMID:38239285]. It is widely utilized in Indonesia as a nutritional plant and a key ingredient in jamu (traditional medicine) [PMID:34194529].

Usages traditionnels

Traditionally used to treat lack of appetite, stomach disorders, liver illness, constipation, bloody diarrhea, dysentery, arthritis, children's fevers, hypotriglyceridaemia, hemorrhoids, vaginal discharge, rheumatism, skin eruptions, fatigue, and gastrointestinal disorders [PMID:34194529, PMID:35933899].

Composés actifs

The plant contains over 40 active compounds, including curcuminoids (curcumin), terpenoids (specifically the bisabolene sesquiterpenoid xanthorrhizol), phenolic compounds, alnustone, and gingerol derivatives such as xanthorrhiza A and B [PMID:34194529, PMID:35933899, PMID:38284732, PMID:40975864].

Mécanisme d'action

Xanthorrhizol exhibits anti-inflammatory and antioxidative properties and protects against particulate matter-induced skin damage by modulating inflammatory cytokines and oxidative stress responses [PMID:40573205]. It also demonstrates the ability to inhibit pancreatic lipase, which is involved in fat metabolism [PMID:39852154].

Preuves cliniques

Preuve AType 2 Diabetes Mellitus

Supplementation with curcumin (including C. xanthorrhiza) led to a significant decrease in fasting blood glucose [PMID:39683570].

Preuve CIrritable Bowel Syndrome (IBS)

Extracts of Curcuma xanthorrhiza have not shown significant clinical outcomes for IBS [PMID:41599795].

Preuve DLiver Damage

Extracts reduced acute elevation of serum transaminases and alleviated liver damage induced by acetaminophen and carbon tetrachloride in mice [PMID:8571920].

Preuve DCancer Cachexia

C. xanthorrhiza extract and xanthorrhizol significantly attenuated loss of body weight and epididymal fat mass in CT26 tumor-bearing mice [PMID:38298864].

Interactions médicamenteuses

Co-administration of C. xanthorrhiza extract in rats significantly increased the area under the curve (AUC) of R- and S-warfarin [PMID:34062109]. Ethanol and aqueous extracts inhibited UDP-glucuronosyltransferase (UGT1A1 and UGT2B7) activities in human recombinant enzymes [PMID:27695274].

Synthèse des preuves

Evidence ranges from high-level meta-analyses for glycemic control (Level A) to preliminary in vitro and animal studies (Level D) for hepatoprotective, anticancer, and antimicrobial activities. Clinical evidence for IBS is negative.

Sources PubMed

1.PMID: 39683570 (2024) — Curcumin Attenuates Hyperglycemia and Inflammation in Type 2 Diabetes Mellitus: Quantitative Analysis of Randomized Controlled Trial. · Nutrients
2.PMID: 34194529 (2021) — Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, Phytochemistry, Biotechnology, and Pharmacological Activities. · Evidence-based complementary and alternative medicine : eCAM
3.PMID: 37346311 (2022) — Classification of Curcuma longa and Curcuma zanthorrhiza using transfer learning. · PeerJ. Computer science
4.PMID: 35933899 (2022) — Xanthorrhizol, a potential anticancer agent, from Curcuma xanthorrhiza Roxb. · Phytomedicine : international journal of phytotherapy and phytopharmacology
5.PMID: 37536430

Curcuma javanais

Sources et citations

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Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Curcuma javanais

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Synthèse des preuves

Sources PubMed

Sources gouvernementales