Khaya Anthotheca (Khaya anthotheca): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Khaya anthotheca work to treat malaria?

Khaya anthotheca contains limonoids, particularly khayalactone and anthothecol, which demonstrate antimalarial activity by inhibiting Plasmodium parasite development. These compounds interfere with parasite cell membranes and disrupt essential metabolic processes. Laboratory studies show these limonoids also possess antipyretic and anti-inflammatory properties that help reduce fever symptoms. Evidence level: C (preclinical studies support mechanism; human clinical trials are limited).

Can Khaya anthotheca interact with prescription medications?

Khaya anthotheca may interact with medications metabolized by the liver, including antimalarial drugs, anticoagulants, and medications requiring precise dosing. The limonoids and alkaloids could potentially affect liver enzyme activity. Patients taking prescription medications should consult a healthcare provider before use, as formal drug interaction studies are lacking. Evidence level: D (theoretical interactions based on constituent properties).

What is the correct dosage for Khaya anthotheca bark decoction?

The traditional adult dosage is 200ml of bark decoction taken twice daily. To prepare, boil approximately 10-15 grams of dried bark in water for 15-20 minutes. This preparation is used for malaria, fever, and digestive complaints. Dosage should not exceed traditional recommendations without professional guidance. Evidence level: C (based on traditional use; standardized clinical dosing not established).

Is Khaya anthotheca safe to take during pregnancy?

Khaya anthotheca is unsafe during pregnancy and breastfeeding. The limonoids and alkaloids may stimulate uterine contractions and pose risks to fetal development. Traditional practitioners in East Africa explicitly contraindicate its use in pregnant women. Women of childbearing age should avoid this herb unless using reliable contraception. Evidence level: C (traditional contraindication supported by constituent analysis).

What are the traditional medicinal uses of Khaya anthotheca?

Khaya anthotheca bark is traditionally used in Uganda and Tanzania for treating malaria, fever, wound healing, diarrhea, and respiratory infections. The bark decoction serves as an antimalarial remedy and wound wash. Traditional healers have used this tree medicinally for generations, though scientific evidence remains preliminary. Evidence level: C (well-documented traditional use with supporting pharmacological studies).

What side effects can Khaya anthotheca cause?

Common side effects include nausea and mild digestive upset, particularly when taken on an empty stomach. Some individuals report abdominal discomfort or loose stools. People with liver disease should avoid this herb due to potential hepatotoxic effects from concentrated limonoids. Discontinue use if severe gastrointestinal symptoms develop. Evidence level: C (based on traditional use reports and constituent analysis).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 20 articles PubMed · modèle : gemma4:31b

Résumé

Khaya anthotheca (African mahogany) is a medicinal tree native to Central and Eastern Africa used traditionally to treat fevers, infections, and candidiasis [PMID:23250916, PMID:40883852, PMID:23501156].

Contexte

Khaya anthotheca is a slow-growing tree native to Central and Eastern Africa [PMID:23250916]. It is recognized as a species of African mahogany [PMID:4231052].

Usages traditionnels

Traditional uses include treating fevers, febrile conditions, microbial infections, worm infestations [PMID:23501156], and candidiasis [PMID:40883852]. In Cameroon, it is used for its anxiolytic properties and to alleviate vaginal dryness in postmenopausal women [PMID:33831470].

Composés actifs

The plant contains various limonoids, including anthothecol [PMID:17913482, PMID:4231052], anthothecanolide, 3-O-acetylanthothecanolide, 2,3-di-O-acetylanthothecanolide, and 6R,8alpha-dihydroxycarapin [PMID:15893779]. Other isolated compounds include scopoletin, 3-O-beta-D-glucopyranosylsitosterol [PMID:15787447], and grandifolione [PMID:23501156].

Mécanisme d'action

Anthothecol-encapsulated PLGA-nanoparticles inhibit pancreatic cancer stem cell growth by disrupting the binding of Gli to DNA and inhibiting Gli transcription and Gli target genes, while up-regulating E-cadherin and inhibiting N-cadherin and Zeb1 [PMID:26199979].

Preuves cliniques

Preuve DVanadium-induced anxiety and memory loss (mice)

Aqueous extract of K. anthotheca showed ameliorative effects on anxiety, memory loss, and pathologies in the brain and ovary [PMID:33831470]

Preuve DMalaria (Plasmodium falciparum)

Anthothecol demonstrated potent antimalarial activity in vitro with IC(50) values of 1.4 and 0.17 microM [PMID:17913482]

Preuve DCandidiasis

Stem barks of K. anthotheca were verified for antifungal activity against Candida albicans in vitro [PMID:39533448]

Preuve DPancreatic Cancer Stem Cells

Anthothecol-encapsulated nanoparticles inhibited cell proliferation, colony formation, and induced apoptosis in pancreatic CSCs in vitro [PMID:26199979]

Sécurité et effets indésirables

Wood dust from K. anthotheca has been linked to dermatitis in furniture factory workers, specifically due to the constituent anthothecol [PMID:4231052].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential antimalarial, antifungal, and anxiolytic activities, as well as potential for cancer stem cell inhibition.

Sources PubMed

1.PMID: 38900778 (2024) — Pharmacological and behavioral investigation of putative self-medicative plants in Budongo chimpanzee diets. · PloS one
2.PMID: 33831470 (2021) — Ameliorative effects of the aqueous extract of Khaya anthotheca (Welw.) C.DC (Meliaceae) in vanadium induced anxiety, memory loss and pathologies in the brain and ovary of mice. · Journal of ethnopharmacology
3.PMID: 15787447 (2005) — Acylperoxylated and seco-mexicanolides from stems of Khaya anthotheca. · Journal of natural products
4.PMID: 39533448 (2024) — In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda. · Tropical medicine and health
5.PMID: 4231052 (1968) — Dermatitis due to the wood dusts of Khaya anthotheca and Machaerium scleroxylon.

Khaya Anthotheca

Sources et citations

Calculer une dose sûre de Khaya Anthotheca

Terminalia Macroptera

Ximenia Americana

Waltheria Indica

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Khaya Anthotheca

Sources et citations

Calculer une dose sûre de Khaya Anthotheca

Plantes associées

Terminalia Macroptera

Ximenia Americana

Waltheria Indica

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales