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PubMed · Rhododendron groenlandicum (Labrador tea), an antidiabetic plant from the traditional pharmacopoeia of the Canadian Eastern James Bay Cree, improves renal integrity in the diet-induced obese mouse model. (2016)
PubMed · Fourteen polymorphic microsatellite markers for the widespread Labrador tea (<i>Rhododendron groenlandicum</i>). (2019)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Labrador tea (Rhododendron groenlandicum) is a medicinal plant used by Indigenous peoples in North America, demonstrating potential antidiabetic and renoprotective effects in animal models [PMID:26916332, PMID:25916863].
Contexte
Labrador tea refers to the dried leaves of species such as Rhododendron groenlandicum, R. tomentosum, or R. neoglandulosum [PMID:25156477]. It is an evergreen shrub found in temperate and subarctic regions of the Northern Hemisphere [PMID:38592945].
Usages traditionnels
Used by the Cree Nations of northern Quebec and other First Nations communities as a beverage and medicinal tea [PMID:25916863, PMID:32113170]. It has been used in Native American traditional medicine to treat inflammatory pathologies including asthma, rheumatisms, and burns [PMID:17156957], and by indigenous peoples in Alaska, Canada, and Greenland for a diversity of ailments [PMID:29701283].
Composés actifs
The plant contains essential oils, flavonoids, phenolic acids, and terpenoids [PMID:38592945]. Specific identified compounds include (+)-catechin, (-)-epicatechin, quercetin [PMID:26707751, PMID:39877830], ursolic acid [PMID:39877830, PMID:29701283], and germacrone, which is a major component of its essential oil [PMID:24263998]. It is also a source of ascorbic acid [PMID:25156477].
Mécanisme d'action
In diet-induced obesity mouse models, Labrador tea stimulated the insulin-dependent Akt pathway [PMID:25916863]. In vitro, it has shown glitazone-like activity in 3T3-L1 adipogenesis bioassays [PMID:26707751, PMID:26508979].
Preuves cliniques
Preuve DDiabetes/Insulin Resistance
In a diet-induced obesity mouse model, extract significantly reduced blood glucose (13%), plasma insulin (65%), and the response to an oral glucose tolerance test (18.2%), while preventing hepatic steatosis [PMID:25916863].
Preuve DRenal Integrity
In diet-induced obese mice, the plant extract showed a tendency to improve microalbuminuria and renal fibrosis [PMID:26916332].
Preuve DInflammation
Methanol extracts of leaves and twigs inhibited nitric oxide (NO) release in LPS-stimulated RAW 264.7 macrophages [PMID:17156957].
Preuve DOral Bacteria (F. nucleatum)
Essential oils showed antibacterial activity and decreased bacterial viability in pre-formed biofilms [PMID:33182686].
Sécurité et effets indésirables
The beverage should not be consumed more than once daily due to the toxicity of ledol and grayanotoxin [PMID:25156477].
Interactions médicamenteuses
Decoctions of Rhododendron groenlandicum may have the potential to inhibit cytochrome P450 3A4 (CYP3A4)-mediated metabolism, with inhibition increasing the longer the leaves are brewed [PMID:24971793].
Posologie et administration
A common recipe involves adding one teaspoonful of dried leaves to one cup of boiling water and brewing for 5 minutes [PMID:25156477]. Consult a healthcare provider.
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), with some review-level data (Level C) regarding traditional use and phytochemistry. No human clinical trials were provided.
Sources PubMed
1.PMID: 26916332 (2016) — Rhododendron groenlandicum (Labrador tea), an antidiabetic plant from the traditional pharmacopoeia of the Canadian Eastern James Bay Cree, improves renal integrity in the diet-induced obese mouse model. · Pharmaceutical biology
2.PMID: 25916863 (2016) — Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model. · European journal of nutrition
3.PMID: 26707751 (2016) — A combination of (+)-catechin and (-)-epicatechin underlies the in vitro adipogenic action of Labrador tea (Rhododendron groenlandicum), an antidiabetic medicinal plant of the Eastern James Bay Cree pharmacopeia. · Journal of ethnopharmacology
4.PMID: 25156477 (2015) — Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. · Journal of the science of food and agriculture
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Trace elements in Labrador Tea (Rhododendron groenlandicum): How predominant sources to the plants impact the chemical composition of hot water extracts.
· Environmental research
6.PMID: 39877830 (2024) — Alaska's Flora as a Treatment for Cancer. · International journal of biopharmaceutical sciences
7.PMID: 38592945 (2024) — Phytochemical Profiling and Biological Activities of Rhododendron Subsect. Ledum: Discovering the Medicinal Potential of Labrador Tea Species in the Northern Hemisphere. · Plants (Basel, Switzerland)
8.PMID: 26508979 (2015) — Adipogenic Activity of Wild Populations of Rhododendron groenlandicum, a Medicinal Shrub from the James Bay Cree Traditional Pharmacopeia. · Evidence-based complementary and alternative medicine : eCAM
9.PMID: 24971793 (2014) — The effect of Cree traditional medicinal teas on the activity of human cytochrome P450-mediated metabolism. · Journal of ethnopharmacology
10.PMID: 29701283 (2018) — Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia. · Phytotherapy research : PTR
11.PMID: 17156957 (2007) — Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. · Journal of ethnopharmacology
12.PMID: 33182686 (2020) — Effects of Labrador Tea, Peppermint, and Winter Savory Essential Oils on Fusobacterium nucleatum. · Antibiotics (Basel, Switzerland)
13.PMID: 24263998 (1990) — Germacrone defends labrador tea from browsing by snowshoe hares. · Journal of chemical ecology