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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Glycyrrhiza glabra (deglycyrrhizinated)
Processed licorice with glycyrrhizin removed, used safely for gastric ulcers and GI mucous membranes.
Deglycyrrhizinated licorice (DGL) is a processed form of Glycyrrhiza glabra with the steroid-like compound glycyrrhizin removed, making it safe for long-term gastrointestinal use without mineralocorticoid side effects. It is primarily used for peptic ulcers, gastric mucosal protection, GERD, and aphthous stomatitis, with key active compounds including isoliquiritigenin, liquiritigenin, and glabridin. Evidence supports its efficacy in promoting mucosal healing and reducing ulcer recurrence.
DGL exerts gastroprotective effects through multiple mechanisms: isoliquiritigenin and liquiritigenin inhibit 15-hydroxyprostaglandin dehydrogenase, increasing local prostaglandin E2 levels which enhance mucus secretion and bicarbonate production. Flavonoids like glabridin scavenge reactive oxygen species and reduce gastric inflammation. Additionally, DGL stimulates epithelial growth factor (EGF) and nitric oxide pathways, promoting angiogenesis and mucosal repair. Unlike whole licorice, DGL lacks glycyrrhizin, thus avoiding 11β-hydroxysteroid dehydrogenase inhibition and subsequent pseudohyperaldosteronism.
Processed licorice with glycyrrhizin removed, used safely for gastric ulcers and GI mucous membranes.
Deglycyrrhizinated licorice (DGL) is a processed form of Glycyrrhiza glabra with the steroid-like compound glycyrrhizin removed, making it safe for long-term gastrointestinal use without mineralocorticoid side effects. It is primarily used for peptic ulcers, gastric mucosal protection, GERD, and aphthous stomatitis, with key active compounds including isoliquiritigenin, liquiritigenin, and glabridin. Evidence supports its efficacy in promoting mucosal healing and reducing ulcer recurrence.
DGL exerts gastroprotective effects through multiple mechanisms: isoliquiritigenin and liquiritigenin inhibit 15-hydroxyprostaglandin dehydrogenase, increasing local prostaglandin E2 levels which enhance mucus secretion and bicarbonate production. Flavonoids like glabridin scavenge reactive oxygen species and reduce gastric inflammation. Additionally, DGL stimulates epithelial growth factor (EGF) and nitric oxide pathways, promoting angiogenesis and mucosal repair. Unlike whole licorice, DGL lacks glycyrrhizin, thus avoiding 11β-hydroxysteroid dehydrogenase inhibition and subsequent pseudohyperaldosteronism.