Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Mai Dong contains active compounds including methylophiopogonanone, ophiopogonin, beta-sitosterol, flavonoids, and polysaccharides that contribute to its therapeutic effects. These compounds demonstrate anti-inflammatory properties and support the herb's traditional use for nourishing yin and moistening dryness. In Traditional Chinese Medicine, Mai Dong works by nourishing yin fluids, clearing heat from the heart, and calming the spirit. The polysaccharides and steroidal saponins may support mucosal integrity and immune modulation. Evidence Level: C.
Does Mai Dong interact with any medications?
Limited clinical research exists on Mai Dong's specific drug interactions. Due to its moisturizing properties, it may theoretically interact with medications that have drying effects. Patients taking immunosuppressants or diabetes medications should exercise caution, as polysaccharides in Mai Dong may affect immune function and blood sugar regulation. Always consult a qualified healthcare provider before combining Mai Dong with prescription medications. Evidence Level: C/Traditional.
What is the recommended dosage for Mai Dong?
The standard adult dosage for Mai Dong is 9-15 grams of dried root per day when prepared as a decoction. This dosage is based on Traditional Chinese Medicine clinical tradition. Dosage may vary depending on the specific formulation, condition being treated, and individual constitution. Mai Dong is typically combined with other herbs in TCM formulas rather than used alone. Always follow guidance from a qualified herbalist for personalized dosing. Evidence Level: Traditional.
Is Mai Dong safe to take during pregnancy?
Mai Dong is considered unsafe during pregnancy and should be avoided. Traditional Chinese Medicine contraindications advise against its use in pregnant women due to potential effects on uterine function. Pregnant women should not use Mai Dong without explicit guidance from a qualified healthcare provider specializing in botanical medicine. Alternative herbs with established pregnancy safety profiles should be considered instead. Evidence Level: C/Traditional.
What is Mai Dong used for in Traditional Chinese Medicine?
Mai Dong is primarily used in Traditional Chinese Medicine to nourish yin, moisten dryness, clear heart heat, and calm the spirit. It is commonly prescribed for conditions associated with yin deficiency, including dry cough, thirst, irritability, and insomnia. The herb is closely related to Ophiopogon and is often used similarly for these indications. Mai Dong's anti-inflammatory properties also support its use in addressing heat-related conditions. Evidence Level: C.
What are the side effects and contraindications of Mai Dong?
Mai Dong may cause loose stools, particularly in individuals with a cold constitution or weak spleen function. It is specifically contraindicated for those with spleen deficiency accompanied by diarrhea, as its cooling and moistening properties can worsen these conditions. Other side effects are not well documented in clinical literature. Discontinue use if digestive upset occurs and consult a qualified herbalist. Evidence Level: Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Mai Dong (including Liriope muscari and Ophiopogon japonicus) is a traditional Chinese medicine tonic used to nourish yin and promote fluid production [PMID:26826325, PMID:40882790].
Contexte
Mai Dong refers to the tuberous roots of species such as Liriope muscari, Ophiopogon japonicus, and Liriope spicata [PMID:36291700, PMID:38280236]. It is categorized by geographical origin, such as Zhe MaiDong (Zhejiang) and Chuan MaiDong (Sichuan) [PMID:36291700, PMID:33584266].
Usages traditionnels
Traditionally used to nourish yin, promote body fluid production, moisten the lung, ease the mind, clear heart fire, and treat lung dryness, dry cough, thirst, and insomnia [PMID:26826325, PMID:39366531, PMID:40882790].
Composés actifs
Active components include steroidal saponins [PMID:38658153], polysaccharides composed of beta-fructose and alpha-glucose [PMID:28732860], homoisoflavonoids (notably methylophiopogonanone A and B) [PMID:20226614], and specific glycosides such as Liriopem I, Liriopem II, and DT-13 [PMID:26073343].
Mécanisme d'action
Mechanisms include the inhibition of the IKK-NF-kappaB pathway to increase insulin secretion [PMID:32605924], suppression of oxidative stress and inflammation in lung cancer under intermittent hypoxia [PMID:36058477], and modulation of the Th17/Treg immune balance and gut microbiota in autoimmune contexts [PMID:39524804]. It may also inhibit the cGAS-STING signaling pathway to reduce oxidative stress in salivary gland epithelial cells [PMID:40882790].
Preuves cliniques
Preuve AParoxysmal Atrial Fibrillation (PAF)
Adding Liriope Tuber to conventional medicine reduced PAF frequency, left atrium diameter, and P-wave dispersion [PMID:39247398]
Shashen-Maidong decoction combined with Western medicine was evaluated for efficacy and safety in a retrospective cohort [PMID:38045652]
Preuve DCandida albicans Biofilm
Liriope muscari extract significantly reduced biofilm formation by 51.65% at 1.56 ug/mL and inhibited dimorphic transition [PMID:38786162]
Preuve DDiabetes/Hyperglycemia
Maidong polysaccharide extract increased insulin secretion and reduced blood glucose in db/db mice [PMID:32605924]
Sécurité et effets indésirables
Concerns have been raised regarding the use of paclobutrazol (a plant growth regulator) during production, which may be a health concern [PMID:33584266, PMID:38280236].
Interactions médicamenteuses
Ethanol extracts of Ophiopogon japonicus have been shown to activate the pregnane X receptor (PXR) and induce cytochrome P450 3A4 (CYP3A4), raising concerns for interactions with drugs metabolized by CYP3A4 [PMID:26137250].
Synthèse des preuves
Evidence consists primarily of in vitro studies, animal models (mice/rats), and one systematic review/meta-analysis of RCTs for atrial fibrillation. Clinical data for other conditions are limited to retrospective or preclinical research.
Sources PubMed
1.PMID: 36058477 (2022) — Shashen-Maidong Decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation. · Journal of ethnopharmacology
2.PMID: 39419302 (2025) — Mechanism of Shashen-Maidong herb pair in treating hepatocellular carcinoma using network pharmacology and experimental validation. · Journal of ethnopharmacology
3.PMID: 36291700 (2022) — Quality Evaluation of Ophiopogon japonicus from Two Authentic Geographical Origins in China Based on Physicochemical and Pharmacological Properties of Their Polysaccharides. · Biomolecules
4.PMID: 38786162 (2024) — Inhibition of Candida albicans Biofilm Formation and Attenuation of Its Virulence by Liriope muscari. · Antibiotics (Basel, Switzerland)
5.PMID: 39524804 (2024) — Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gut microbiota and restoration of Th17/Treg immune balance.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 40574364 (2025) — Mechanism of Shashen Maidong Decoction in the Treatment of Radiation Pneumonitis Based on Network Pharmacology and Molecular Docking. · Current pharmaceutical design
7.PMID: 40882790 (2026) — Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sjögren's syndrome by reducing oxidative stress in salivary gland epithelial cells. · Journal of ethnopharmacology
8.PMID: 33584266 (2020) — A Novel Method to Identify Three Quality Grades of Herbal Medicine Ophiopogonis Radix by Microscopic Quantification. · Frontiers in pharmacology
9.PMID: 40468932 (2025) — Shashen Maidong Decoction's Effects on Chronic Bronchitis: A Multi-Method Approach. · Current pharmaceutical design
10.PMID: 39209002 (2025) — ShaShen-MaiDong decoction attenuates bleomycin-induced pulmonary fibrosis by inhibiting TGF-β/smad3, AKT/MAPK, and YAP/TAZ pathways. · Journal of ethnopharmacology
11.PMID: 39366531 (2024) — Mechanism of DT-13 regulating macrophages in diabetic wound healing. · Cellular signalling
12.PMID: 38280236 (2024) — Quality variation of maidong (Ophiopogon japonicus and Liriope spicata) - A HPTLC-based approach. · Journal of pharmaceutical and biomedical analysis
13.PMID: 36578338 (2022) — De Novo transcriptome combined with physiological analyses revealed key genes for cadmium accumulation in Zhe-Maidong (Ophiopogon japonicus). · Frontiers in plant science
14.PMID: 32354363 (2020) — Photosynthetic performance and growth responses of Liriope muscari (Decne.) L.H. Bailey (Asparagaceae) planted within poplar forests having different canopy densities. · BMC ecology
15.PMID: 20226614 (2010) — Characterization of homoisoflavonoids in different cultivation regions of Ophiopogon japonicus and related antioxidant activity. · Journal of pharmaceutical and biomedical analysis
16.PMID: 36432743 (2022) — Genetic Structure of the Liriope muscari Polyploid Complex and the Possibility of Its Genetic Disturbance in Japan. · Plants (Basel, Switzerland)
17.PMID: 30743664 (2011) — First Report of the Spiral Nematode Scutellonema brachyurum on Lilyturf in the United States. · Plant disease
18.PMID: 26826325 (2016) — Ophiopogon japonicus--A phytochemical, ethnomedicinal and pharmacological review. · Journal of ethnopharmacology
19.PMID: 26411727 (2016) — Multiple mechanism confers natural tolerance of three lilyturf species to glyphosate. · Planta
20.PMID: 38658153 (2024) — [Uncovering the molecular mechanisms behind steroidal saponin accumulation in Liriope muscari (Decne.) Baily through transcriptome sequencing and bioinformatics analysis]. · Sheng wu gong cheng xue bao = Chinese journal of biotechnology
21.PMID: 39247398 (2024) — Effectiveness and safety of Liriope Tuber (Liriopis seu Ophiopogonis Tuber, Maidong) included traditional herbal medicine for patients with paroxysmal atrial fibrillation: A systematic review, meta-analysis, and network analysis. · Integrative medicine research
22.PMID: 37189139 (2023) — Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer. · BMC complementary medicine and therapies
23.PMID: 28732860 (2017) — Structure features and in vitro hypoglycemic activities of polysaccharides from different species of Maidong. · Carbohydrate polymers
24.PMID: 26073343 (2015) — Novel cytotoxic steroidal glycosides from the roots of Liriope muscari. · Chinese journal of natural medicines
25.PMID: 38045652 (2023) — The Efficacy and Safety of Shashen-Maidong Decoction Combined with Western Medicine in the Treatment of Omicron Infected Individuals Over 85 Years Old: A Retrospective Study. · Infection and drug resistance
26.PMID: 32605924 (2020) — A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-κB pathway and IL-1β-induced islet inflammation and increases insulin secretion. · The Journal of biological chemistry
27.PMID: 26137250 (2015) — Ophiopogon japonicus strains from different cultivation regions exhibit markedly different properties on cytotoxicity, pregnane X receptor activation and cytochrome P450 3A4 induction. · Biomedical reports
28.PMID: 38285695 (2024) — Saengmaeksan, a traditional polyherbal formulation containing Panax ginseng, improves energy metabolism during exercise. · PloS one
29.PMID: 31341902 (2019) — Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats. · BioMed research international
30.PMID: 40686161 (2025) — [Tracing origin of "Qinggong Maidong" production area based on analysis of literature and historical materials and identification of characteristics of Qinggong medicinal materials and cultural relics]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica