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Notopterygium incisium
Notopterygium incisium
Conditions de froid et de vent en médecine traditionnelle chinoise
PubMed · Anti-Inflammatory Phenolic Acid Esters from the Roots and Rhizomes of Notopterygium incisium and Their Permeability in the Human Caco-2 Monolayer Cell Model. (2017)
PubMed · A study on the mutagenicity of 102 raw pharmaceuticals used in Chinese traditional medicine. (1991)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Notopterygium incisium
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
How does Notopterygium incisium work to relieve pain?
Notopterygium incisium contains active compounds including notopterol, isoimperatorin, and various coumarins that contribute to its therapeutic effects. These compounds exert anti-inflammatory and analgesic properties through modulation of inflammatory pathways and pain signaling mechanisms. Research suggests the coumarin components may inhibit pro-inflammatory mediators, while notopterol has demonstrated analgesic activity in preclinical studies. In Traditional Chinese Medicine terms, the herb dispels wind-cold and unblocks painful obstruction, explaining its traditional use for rheumatic conditions and headache. Evidence level: C.
Is Notopterygium incisium safe to take during pregnancy?
Notopterygium incisium is contraindicated during pregnancy and should be avoided by pregnant women. Traditional Chinese Medicine considers this herb unsafe during pregnancy due to its warming, dispersing properties and potential effects on uterine activity. Additionally, individuals with Yin deficiency with heat patterns should avoid this herb according to TCM principles. Women who are pregnant or trying to conceive should consult a qualified healthcare provider before using any herbal supplements. Evidence level: Traditional.
Does Notopterygium incisium interact with any medications?
Limited clinical data exists regarding drug interactions with Notopterygium incisium. The coumarin compounds present in this herb may theoretically interact with anticoagulant and antiplatelet medications, potentially increasing bleeding risk. Patients taking warfarin, aspirin, clopidogrel, or other blood-thinning medications should exercise caution and consult a healthcare provider before use. Additionally, the herb may affect metabolism of certain drugs processed by cytochrome P450 enzymes. Always inform your healthcare provider of all herbal supplements you are taking. Evidence level: C.
What is the recommended dosage for Notopterygium incisium?
The standard adult dosage for Notopterygium incisium is 3-9 grams of dried rhizome daily, typically prepared as a decoction in Traditional Chinese Medicine. This herb is commonly combined with other TCM herbs in formulations tailored to individual patterns and conditions. Dosage may vary based on the specific condition being treated, the formulation used, and individual patient factors. Always follow the guidance of a qualified TCM practitioner or healthcare provider for personalized dosing recommendations. Evidence level: Traditional.
What is Notopterygium incisium used for in Traditional Chinese Medicine?
Notopterygium incisium is used in Traditional Chinese Medicine primarily for wind-cold conditions, including headache (particularly occipital headache) and rheumatic joint pain. The herb is valued for its ability to dispel wind-cold, relieve pain, and address dampness in the body. It is commonly prescribed for conditions characterized by joint stiffness, body aches, and headache accompanied by aversion to cold. The herb's documented anti-inflammatory and analgesic properties support these traditional applications. Evidence level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Notopterygium incisium, known as 'Qianghuo', is a Chinese endemic herb used in traditional medicine for its anti-inflammatory and analgesic properties [PMID:39064831, PMID:39094757].
Contexte
Notopterygium incisium is a plant genus belonging to the Apiaceae (Umbelliferae) family, endemic to high-altitude regions of China such as Tibet and Gansu [PMID:39064831, PMID:28336469, PMID:28696392]. The medicinal parts are primarily the roots and rhizomes [PMID:39064831, PMID:39094757].
Usages traditionnels
It is traditionally used to treat headaches, colds, rheumatoid arthritis, and to disperse 'cold' and painful obstructions from wind and damp [PMID:39064831, PMID:39094757, PMID:28336469, PMID:31908072]. It is also used in Qianghuo Yufeng Decoction for liver and kidney insufficiency, mental paralysis, and dementia [PMID:39094757, PMID:31783135].
Composés actifs
The herb contains over 500 compounds, including volatile oils, coumarins (such as notopterol and isoimperatorin), enynes, sesquiterpenes, flavonoids, phenolic acid esters, and polysaccharides (NIP) [PMID:39064831, PMID:40020461, PMID:41053923, PMID:37143438, PMID:28587222]. Notopterol is identified as a major constituent [PMID:2285981, PMID:36986461].
Mécanisme d'action
Mechanisms include inhibition of the TLR4-NF-κB pathway for neuroinflammation [PMID:39094757], inhibition of PI3K/Akt/GPX4-mediated ferroptosis in osteoarthritis [PMID:40020461], and modulation of the cAMP signaling pathway to reduce synovial inflammation [PMID:41053923]. Notopterol also acts via α7nAChR-dependent metabolic reprogramming of macrophages [PMID:41442994] and inhibits the NF-κB pathway while activating the PI3K/Akt/Nrf2 pathway in periodontal tissue [PMID:37819772]. Polysaccharides (NIP) inhibit NF-κB and JAK/STAT3 signaling [PMID:37143438].
Preuves cliniques
Preuve BAxial undifferentiated spondyloarthritis
Qiangji Recipe (containing N. incisium) was used as an adjunctive treatment in a four-week study [PMID:25790672]
Preuve DOsteoarthritis (Animal Model)
Notopterol significantly alleviated pain, gait abnormalities, and attenuated cartilage degradation in mice [PMID:40020461]; Isoimperatorin reduced synovial inflammation in rats [PMID:41053923]
Preuve DAlzheimer's Disease (Animal Model)
Root extract (NRE) rescued cognitive deficits and attenuated amyloid-beta, tau, and neuroinflammation pathology in APP/PS1 mice [PMID:31783135, PMID:39094757]
Preuve DNeuropathic Pain (Animal Model)
Water extract reduced cold allodynia by regulating TRPA1 in mice [PMID:36587876]
Notopterol improved exercise capacity and alleviated cardiac dysfunction by suppressing P2X7R and pyroptosis signals [PMID:36986461]
Preuve D
Sécurité et effets indésirables
In a study of 102 raw pharmaceuticals, Notopterygium incisium was found to be positive in chromosomal aberration and micronucleus assays in mice [PMID:2027343].
Synthèse des preuves
The majority of evidence is derived from in vitro studies and animal models (Level D), focusing on anti-inflammatory and neuroprotective effects. There is limited clinical data (Level B) regarding its use in complex herbal recipes for spondyloarthritis.
Sources PubMed
1.PMID: 39064831 (2024) — Phytochemistry and Biological Profile of the Chinese Endemic Herb Genus Notopterygium. · Molecules (Basel, Switzerland)
2.PMID: 39094757 (2024) — Notopterygium incisum roots extract (NRE) alleviates neuroinflammation pathology in Alzheimer's disease through TLR4-NF-κB pathway. · Journal of ethnopharmacology
3.PMID: 40020461 (2025) — Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis. · International immunopharmacology
4.PMID: 2285981 (1990) — Isolation of two new coumarin glycosides from Notopterygium forbesii and evaluation of a Chinese crude drug, qiang-huo, the underground parts of N. incisum and N. forbesii, by high-performance liquid chromatography. · Chemical & pharmaceutical bulletin
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Rhizoma et radix significantly alleviated skin symptoms and reduced inflammation in IMQ-induced mice [PMID:41253925]
— Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
· Journal of cellular and molecular medicine
6.PMID: 36587876 (2023) — Water extract of Notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1. · Journal of ethnopharmacology
7.PMID: 28336469 (2017) — A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum. · Journal of ethnopharmacology
8.PMID: 31908072 (2020) — Rapid discrimination of Notopterygium incisum and Notopterygium franchetii based on characteristic compound profiles detected by UHPLC-QTOF-MS/MS coupled with multivariate analysis. · Phytochemical analysis : PCA
10.PMID: 30639766 (2019) — Species delimitation and interspecific relationships of the endangered herb genus Notopterygium inferred from multilocus variations. · Molecular phylogenetics and evolution
11.PMID: 35722110 (2022) — Notopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat. · Frontiers in cardiovascular medicine
12.PMID: 2027343 (1991) — A study on the mutagenicity of 102 raw pharmaceuticals used in Chinese traditional medicine. · Mutation research
13.PMID: 35390234 (2023) — A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways. · Journal of basic and clinical physiology and pharmacology
14.PMID: 28587222 (2017) — Anti-Inflammatory Phenolic Acid Esters from the Roots and Rhizomes of Notopterygium incisium and Their Permeability in the Human Caco-2 Monolayer Cell Model. · Molecules (Basel, Switzerland)
15.PMID: 37143438 (2023) — Structure Characterization and Anti-Rheumatoid Arthritis Activity of a Polysaccharide from Notopterygium incisum. · Molecular nutrition & food research
16.PMID: 41253925 (2025) — Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation. · Scientific reports
17.PMID: 19781618 (2009) — Quantitative analysis of chemical constituents in different commercial parts of Notopterygium incisum by HPLC-DAD-MS. · Journal of ethnopharmacology
18.PMID: 33035753 (2020) — Homotherapy for heteropathy active components and mechanisms of Qiang-Huo-Sheng-Shi decoction for treatment of rheumatoid arthritis and osteoarthritis. · Computational biology and chemistry
19.PMID: 36386198 (2022) — Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature. · Frontiers in pharmacology
20.PMID: 41442994 (2026) — Notopterol attenuates synovitis via α7nAChR-dependent metabolic reprogramming of macrophage polarisation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
21.PMID: 38867371 (2024) — Two Undescribed Coumarins from Notopterygium Incisum with Anti-Inflammatory Activity. · Chemistry & biodiversity
23.PMID: 25790672 (2015) — [Adjunctive treatment of axial undifferentiated spondyloarthritis by Qiangji Recipe: a clinical study]. · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
24.PMID: 38685511 (2024) — Chemical constituents from Notopterygium incisum and their anti-neuroinflammatory activity. · Fitoterapia
25.PMID: 31783135 (2020) — Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology. · Journal of ethnopharmacology
26.PMID: 41237013 (2025) — Chromatography-guided purification and characterization of p-hydroxyphenethyl anisate as a potent anti-melanogenesis component from the concentrated Chinese medicine, Qiang Huo. · Preparative biochemistry & biotechnology
27.PMID: 37819772 (2023) — Notopterol Inhibits the NF-κB Pathway and Activates the PI3K/Akt/Nrf2 Pathway in Periodontal Tissue. · Journal of immunology (Baltimore, Md. : 1950)
28.PMID: 28696392 (2017) — Comparative Transcriptome Analysis Reveals Adaptive Evolution of Notopterygium incisum and Notopterygium franchetii, Two High-Alpine Herbal Species Endemic to China. · Molecules (Basel, Switzerland)