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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Nymphaea lotus, also known as water lily, is an aquatic plant used in traditional medicine across Africa and Asia for various therapeutic purposes [PMID:35144171, 32630721]. It is recognized for its antioxidant, anti-inflammatory, and pharmacological activities [PMID:35684520, 33413340].
Contexte
Nymphaea lotus is an aquatic perennial plant distributed in tropical regions, including Africa and Asia [PMID:27215682, 32630721]. It is utilized as a medicinal plant, food source, and in cosmetics [PMID:32630721].
Usages traditionnels
Traditional uses include the management of convulsive episodes in Southwestern Nigeria [PMID:35144171], treatment of pain and inflammatory diseases [PMID:33728272], cure of diarrhoea via rhizome use [PMID:27215682], management of diabetes and its complications [PMID:36645154], and treatment of neuropsychiatric conditions and male sexual disorders in Cameroon [PMID:28291734]. It is also used in the management of sleeping sickness in Angola [PMID:38611890] and as a component of traditional medicines in Thailand [PMID:35684520].
Composés actifs
The plant contains flavonoids, including myricitrin [PMID:30474534], quercetin-3-O-rhamnoside, and kaempferol-3-O-galactoside [PMID:38790706]. Other identified compounds include myricetin-3'-O-(6"-p-coumaroyl)glucoside, macrocyclic derivatives, and pentagalloyl glucose [PMID:12842147]. Extracts are also rich in total phenolics, proanthocyanidins, and tannins [PMID:41903458].
Mécanisme d'action
The herb exhibits antioxidant activity by scavenging radicals and inhibiting lipid peroxidation [PMID:33413340, 11837686]. In anticonvulsant activity, it may involve GABAergic-glutamatergic neurotransmission and antioxidant defense mechanisms [PMID:35144171]. In liver protection, it acts via the inhibition of oxidative stress [PMID:27824613]. In silico studies suggest potential binding affinity for antidiabetic targets such as dipeptidyl peptidase-4, glycogen synthase kinase 3, NADPH oxidase (NOX), and sodium-glucose co-transporter-2, as well as anti-inflammatory target cyclooxygenase-2 [PMID:36645154].
Preuves cliniques
Preuve DConvulsions/Seizures
Aqueous and ethanol extracts demonstrated anticonvulsant activity in mice against chemical-induced seizures [PMID:35144171]
Preuve DErectile Dysfunction
N. lotus (75 and 200 mg/kg/day) alleviated sexual disability in L-NAME hypertensive male rats [PMID:31467581]
Preuve DDiarrhoea
Methanol rhizome extract significantly reduced the frequency and delayed the onset of castor oil-induced and magnesium sulphate-induced diarrhoea in mice [PMID:27215682]
Preuve DChronic Liver Injury
Methanol extract protected against carbon tetrachloride-induced hepatotoxicity in rats by inhibiting oxidative stress [PMID:27824613]
Preuve DPain and Inflammation
Methanol leaf extract demonstrated significant anti-nociceptive and anti-inflammatory activities in rats and mice [PMID:33728272]
Preuve DAnxiety and Depression
Sécurité et effets indésirables
The oral median lethal dose (LD50) of methanol leaf extract was found to be greater than 5,000 mg/kg in rats and mice [PMID:33728272]. Aqueous extract of flowers (200-600 mg/kg) showed no significant toxicity in 28-day subchronic oral studies in Wistar rats [PMID:28291734]. However, ethanolic extracts of the whole plant were reported to be active in brine shrimp lethality tests and caused chromosomal aberrations in rat lymphocytes [PMID:17707603].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant antioxidant, anti-inflammatory, and neuroprotective potentials. No human clinical trials were provided in the source abstracts.
Sources PubMed
1.PMID: 30474534 (2020) — Effects of Myricitrin and Relevant Molecular Mechanisms. · Current stem cell research & therapy
2.PMID: 35144171 (2022) — Anticonvulsant activity of Nymphaea lotus Linn. extract in mice: The role of GABAergic-glutamatergic neurotransmission and antioxidant defence mechanisms. · Epilepsy research
3.PMID: 36809964 (2023) — Comparative transcriptome analysis reveals the regulatory mechanisms of two tropical water lilies in response to cold stress. · BMC genomics
4.PMID: 31467581 (2019) — Nymphaea lotus Linn. (Nymphaeaceae) Alleviates Sexual Disability in L-NAME Hypertensive Male Rats. · Evidence-based complementary and alternative medicine : eCAM
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Aqueous leaf extract exhibited anxiolytic and antidepressant-like activity in mice [PMID:29881419]
Preuve DAfrican Trypanosomiasis
Dichloromethane extract of leaves and leaflets exhibited in vitro activity against Trypanosoma brucei rhodesiense [PMID:38611890]
— Differential Flavonoid and Other Phenolic Accumulations and Antioxidant Activities of Nymphaea lotus L. Populations throughout Thailand.
· Molecules (Basel, Switzerland)
6.PMID: 33413340 (2021) — Ethanolic extract of Nymphaea lotus L. (Nymphaeaceae) leaves exhibits in vitro antioxidant, in vivo anti-inflammatory and cytotoxic activities on Jurkat and MCF-7 cancer cell lines. · BMC complementary medicine and therapies
7.PMID: 33728272 (2021) — Anti-nociceptive, anti-inflammatory and possible mechanism of anti-nociceptive action of methanol leaf extract of Nymphaea lotus Linn (Nymphaeceae). · Journal of traditional and complementary medicine
8.PMID: 32708113 (2020) — A Critical Cross-Species Comparison of Pollen from Nelumbo nucifera Gaertn. vs. Nymphaea lotus L. for Authentication of Thai Medicinal Herbal Tea. · Plants (Basel, Switzerland)
9.PMID: 32630721 (2020) — Enrichment in Antioxidant Flavonoids of Stamen Extracts from Nymphaea lotus L. Using Ultrasonic-Assisted Extraction and Macroporous Resin Adsorption. · Antioxidants (Basel, Switzerland)
10.PMID: 29881419 (2018) — Evaluation of Anxiolytic and Antidepressant-like Activity of Aqueous Leaf Extract of Nymphaea Lotus Linn. in Mice. · Iranian journal of pharmaceutical research : IJPR
11.PMID: 36645154 (2023) — In silico prediction of the possible antidiabetic and anti-inflammatory targets of Nymphaea lotus-derived phytochemicals and mechanistic insights by molecular dynamics simulations. · Journal of biomolecular structure & dynamics
12.PMID: 27215682 (2016) — The effect of methanol rhizome extract of Nymphaea lotus Linn. (Nymphaeaceae) in animal models of diarrhoea. · Journal of ethnopharmacology
13.PMID: 38611890 (2024) — Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b. rhodesiense. · Molecules (Basel, Switzerland)
14.PMID: 37484424 (2023) — GC-MS analysis of aqueous extract of Nymphaea lotus and ameliorative potential of its biosynthesized gold nanoparticles against cadmium-induced kidney damage in rats. · Heliyon
15.PMID: 28291734 (2017) — Safety assessment of the aqueous extract of the flowers of Nymphaea lotus Linn (Nymphaeaceae): Acute, neuro- and subchronic oral toxicity studies in albinos Wistar rats. · Journal of complementary & integrative medicine
16.PMID: 38790706 (2024) — Anti-Aging Potential of the Two Major Flavonoids Occurring in Asian Water Lily Using In Vitro and In Silico Molecular Modeling Assessments. · Antioxidants (Basel, Switzerland)
17.PMID: 17707603 (2007) — Toxicity and mutagenic activity of some selected Nigerian plants. · Journal of ethnopharmacology
18.PMID: 27824613 (2017) — Methanol extract of Nymphaea lotus ameliorates carbon tetrachloride-induced chronic liver injury in rats via inhibition of oxidative stress. · Journal of basic and clinical physiology and pharmacology
19.PMID: 41903458 (2026) — Dose-dependent effects of Nymphaea lotus extract in semen extenders on sperm quality and fertility in Thai native roosters during cooled and cryopreserved storage. · Poultry science
20.PMID: 11837686 (2001) — Total phenolics concentration and antioxidant potential of extracts of medicinal plants of Pakistan. · Zeitschrift fur Naturforschung. C, Journal of biosciences
21.PMID: 12842147 (2003) — Two very unusual macrocyclic flavonoids from the water lily Nymphaea lotus. · Phytochemistry