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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ochrosia elliptica
Tree of Pacific islands and Australia, source of ellipticine anticancer alkaloid, used in traditional Pacific medicine.
Ochrosia elliptica is a Pacific Islands and Australian tree whose bark and leaves contain the anticancer alkaloid ellipticine and related compounds. Traditionally used for fever and skin infections, modern research focuses on ellipticine's topoisomerase II inhibition and DNA intercalation, though clinical use is limited due to toxicity. Key active compounds include ellipticine, 9-methoxyellipticine, and various flavonoids.
Ellipticine acts primarily as a topoisomerase II poison, stabilizing the DNA–topoisomerase II cleavage complex and inducing double-strand breaks. It also intercalates into DNA and inhibits topoisomerase I at higher concentrations. The compound undergoes cytochrome P450 (CYP3A4, CYP1A1/2) metabolism to generate reactive intermediates that contribute to both anticancer activity and hepatotoxicity. Flavonoids in the plant may provide antioxidant and anti-inflammatory effects through NF-κB and COX-2 inhibition.
Tree of Pacific islands and Australia, source of ellipticine anticancer alkaloid, used in traditional Pacific medicine.
Ochrosia elliptica is a Pacific Islands and Australian tree whose bark and leaves contain the anticancer alkaloid ellipticine and related compounds. Traditionally used for fever and skin infections, modern research focuses on ellipticine's topoisomerase II inhibition and DNA intercalation, though clinical use is limited due to toxicity. Key active compounds include ellipticine, 9-methoxyellipticine, and various flavonoids.
Ellipticine acts primarily as a topoisomerase II poison, stabilizing the DNA–topoisomerase II cleavage complex and inducing double-strand breaks. It also intercalates into DNA and inhibits topoisomerase I at higher concentrations. The compound undergoes cytochrome P450 (CYP3A4, CYP1A1/2) metabolism to generate reactive intermediates that contribute to both anticancer activity and hepatotoxicity. Flavonoids in the plant may provide antioxidant and anti-inflammatory effects through NF-κB and COX-2 inhibition.