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OJ
Not CommonRésumée par IA
Oenanthe javanica
Oenanthe javanica
Troubles hépatiques en médecine traditionnelle chinoise
Oenanthe javanica exerts hepatoprotective effects primarily through its flavonoid content, including quercetin and isorhamnetin. These compounds demonstrate antioxidant activity that helps neutralize free radicals and reduce oxidative stress in liver cells. The herb also contains vitamin C, which supports the liver's natural detoxification pathways. Traditional use and preliminary research suggest these bioactive compounds may help reduce inflammation and support liver cell regeneration, though clinical evidence remains limited (Evidence Level C).
Does Oenanthe javanica interact with any medications?
There are currently no documented drug interactions for Oenanthe javanica in the scientific literature. Unlike some hepatoprotective herbs, this species does not appear to significantly affect cytochrome P450 enzymes or drug-metabolizing pathways. However, given its traditional use for liver conditions, patients taking hepatotoxic medications or drugs metabolized by the liver should consult a healthcare provider before use. The herb's mild diuretic properties may theoretically enhance the effects of diuretic medications, though no specific interactions have been reported.
What is the recommended dosage for Oenanthe javanica?
Oenanthe javanica is commonly consumed as a fresh vegetable in Asian cuisine, with no strict dosage limitations for food use. For medicinal purposes as a tea, traditional preparations use 5-10 grams of dried leaf material per day. The herb can be prepared as an infusion by steeping the leaves in hot water for 10-15 minutes. As a food vegetable, it can be eaten raw in salads or cooked in soups and stir-fries. Standardized extract dosages have not been established in clinical trials (Evidence Level C).
Is Oenanthe javanica safe during pregnancy and breastfeeding?
Oenanthe javanica is considered safe for consumption during pregnancy and breastfeeding when used as a food vegetable. The species is non-toxic and has a long history of culinary use in Asian countries without reported adverse effects. Unlike its relative Oenanthe crocata, which is highly toxic, Oenanthe javanica does not contain harmful compounds. However, pregnant women should avoid concentrated medicinal preparations due to insufficient safety data. As with any herb, pregnant women should consult their healthcare provider before using therapeutic doses.
What is Oenanthe javanica used for in traditional medicine?
Oenanthe javanica, also known as water dropwort or Chinese celery, has been used in traditional Chinese medicine primarily for liver conditions, fever reduction, and blood detoxification. The herb is valued for its hepatoprotective properties and is commonly prescribed in folk medicine to support liver health and clear heat from the body. It is also used to address various blood disorders and inflammatory conditions. Beyond medicinal use, it is widely cultivated as a nutritious vegetable rich in flavonoids, quercetin, and vitamin C (Evidence Level C, Traditional).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Oenanthe javanica, also known as water dropwort, is an aquatic perennial plant from the Apiaceae family used in Asia as a vegetable and traditional medicine [PMID:38212839, PMID:31057651]. It is recognized for its nutritional value and potential therapeutic effects, including anti-inflammatory and hepatoprotective properties [PMID:34848704, PMID:24582681].
Contexte
Oenanthe javanica is an aquatic perennial herb native to various regions across Asia that typically grows in wet soils and water [PMID:38212839, PMID:39652676]. It is rich in dietary fiber, vitamins, and minerals [PMID:38212839, PMID:34848704].
Usages traditionnels
In East Asia, specifically China, Korea, and Japan, it has been traditionally used to treat acute and chronic hepatitis, jaundice, alcohol hangovers, abdominal pain, and various inflammatory conditions [PMID:41897725, PMID:31057651, PMID:36552637].
Composés actifs
Identified compounds include coumarins (such as xanthotoxin, bergapten, and isopimpinellin), flavonoids (including isorhamnetin and hyperoside), flavonoid glycosides, organic acids, polyphenols, and volatile terpenoids (notably alpha-terpinolene and p-cymene) [PMID:31057651, PMID:27069833, PMID:28160865, PMID:16104797].
Mécanisme d'action
The herb may exert anti-inflammatory effects by inhibiting the production of inflammatory cytokines in macrophages and restricting the activation of nuclear factor-κB (NF-κB) [PMID:36552637]. Specific compounds like isorhamnetin and hyperoside inhibit inflammasome activation (NLRP3, NLRC4, and AIM2) [PMID:28160865]. Additionally, fermented extracts may attenuate the increase of hepatic enzyme markers (ALT, AST) and modulate CYP2E1, CYP4A2, and PPARγ gene expressions [PMID:24582681].
Preuves cliniques
Preuve BAlcohol hangover
A randomized, double-blind, placebo-controlled crossover trial in 36 healthy adults found that a java water-dropwort extract formulation significantly lowered the blood alcohol area under the curve (AUC) [PMID:41897725]
Preuve DInflammation/Colitis
Ethanolic extract reduced pathological damage to the colon, alleviated weight gain, and decreased colon length in mice with DSS-induced colitis [PMID:36552637]
Preuve DLiver Injury
Fermented field water-dropwort extracts (FDE) demonstrated protective effects against t-BHP-induced hepatotoxicity in HepG2 cells and CCl4-induced liver damage in rats [PMID:24582681]
Sécurité et effets indésirables
Water dropwort can serve as a second intermediate host for Fasciola species (F. hepatica and F. gigantica); consumption of contaminated plants or juices has been linked to human fascioliasis, characterized by liver abscesses and eosinophilia [PMID:26537044, PMID:36277099].
Synthèse des preuves
Evidence consists primarily of in vitro and animal studies (D) regarding hepatoprotection and anti-inflammatory effects, with one clinical trial (B) suggesting efficacy in reducing blood alcohol AUC for hangovers. Review data (C) supports its traditional use and general phytochemical profile.
Sources PubMed
1.PMID: 37895122 (2023) — Plant Extracts as Skin Care and Therapeutic Agents. · International journal of molecular sciences
2.PMID: 38212839 (2024) — Cucumber mosaic virus-induced gene and microRNA silencing in water dropwort (Oenanthe javanica (Blume) DC). · Plant methods
3.PMID: 41897725 (2026) — The Effects of Java Water-Dropwort (Oenanthe javanica) Extract on Alcohol Metabolism and Hangover Symptoms: A Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial. · Foods (Basel, Switzerland)
4.PMID: 35494709 (2020) — Therapeutic potency of fermented field water-dropwort (Oenanthe javanica (Blume) DC.) in ethanol-induced liver injury. · RSC advances
5.PMID: 37050085 (2023) — Metabolomics Analysis Reveals Metabolites and Metabolic Pathways Involved in the Growth and Quality of Water Dropwort [Oenanthe javanica (Blume) DC.] under Nutrient Solution Culture.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 24582681 (2014) — Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
7.PMID: 39652676 (2025) — Exploring optimal soil conditions for high-functional Oenanthe javanica (water dropwort) production. · Journal of the science of food and agriculture
8.PMID: 34848704 (2021) — Integrative genome, transcriptome, microRNA, and degradome analysis of water dropwort (Oenanthe javanica) in response to water stress. · Horticulture research
9.PMID: 34234795 (2021) — Effect of Salt Stress on Growth, Physiological Parameters, and Ionic Concentration of Water Dropwort (Oenanthe javanica) Cultivars. · Frontiers in plant science
10.PMID: 38205019 (2023) — Selection of suitable reference genes for qPCR normalization in different developmental stages of Oenanthe javanica. · Frontiers in plant science
11.PMID: 35464839 (2022) — Integrative Analysis of Long- and Short-Read Transcriptomes Identify the Regulation of Terpenoids Biosynthesis Under Shading Cultivation in Oenanthe javanica. · Frontiers in genetics
12.PMID: 40035850 (2025) — Identification and characterization of anthocyanins' composition and regulatory genes involved in anthocyanins biosynthesis in water dropwort (Oenanthe javanica). · Planta
13.PMID: 33019501 (2020) — Investigation of an Antioxidative System for Salinity Tolerance in Oenanthe javanica. · Antioxidants (Basel, Switzerland)
14.PMID: 33458091 (2020) — The complete chloroplast genome of Oenanthe javanica. · Mitochondrial DNA. Part B, Resources
15.PMID: 35326120 (2022) — Influence of Blanching on the Gene Expression Profile of Phenylpropanoid, Flavonoid and Vitamin Biosynthesis, and Their Accumulation in Oenanthe javanica. · Antioxidants (Basel, Switzerland)
16.PMID: 37528973 (2023) — Integrated morphological, metabolome, and transcriptome analyses revealed the mechanism of exogenous gibberellin promoting petiole elongation in Oenanthe javanica. · Frontiers in plant science
17.PMID: 16104797 (2005) — Identification of characteristic aroma-active compounds from water dropwort (Oenanthe javanica DC.). · Journal of agricultural and food chemistry
18.PMID: 31057651 (2019) — A Review of Oenanthe javanica (Blume) DC. as Traditional Medicinal Plant and Its Therapeutic Potential. · Evidence-based complementary and alternative medicine : eCAM
19.PMID: 38513909 (2024) — Exogenous methyl jasmonate treatment induced the transcriptional responses and accumulation of volatile terpenoids in Oenanthe javanica (Blume) DC. · International journal of biological macromolecules
20.PMID: 36552637 (2022) — Oenanthe javanica Ethanolic Extract Alleviates Inflammation and Modifies Gut Microbiota in Mice with DSS-Induced Colitis. · Antioxidants (Basel, Switzerland)
21.PMID: 26537044 (2015) — Monitoring of Fasciola Species Contamination in Water Dropwort by cox1 Mitochondrial and ITS-2 rDNA Sequencing Analysis. · The Korean journal of parasitology
22.PMID: 27069833 (2016) — Root extract of water dropwort, Oenanthe javanica (Blume) DC, induces protein and gene expression of phase I carcinogen-metabolizing enzymes in HepG2 cells. · SpringerPlus
23.PMID: 28160865 (2017) — Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
24.PMID: 34444382 (2021) — A New Green Model for the Bioremediation and Resource Utilization of Livestock Wastewater. · International journal of environmental research and public health
25.PMID: 36277099 (2022) — Green vegetable juice as a potential source of human fascioliasis in Korea. · One health (Amsterdam, Netherlands)
26.PMID: 42104743 (2026) — Functional Characterization of MeJA-Induced OjTIFY2 in Mediating Salt Stress Tolerance in Oenanthe javanica. · Physiologia plantarum
27.PMID: 41745584 (2026) — Mechanistic Analysis of Physiological and Metabolic Responses in Non-Jointed Water Dropwort Under Phosphorus Stress. · Metabolites
28.PMID: 34228738 (2021) — Uncovering phylogenetic relationships and genetic diversity of water dropwort using phenotypic traits and SNP markers. · PloS one
29.PMID: 33679854 (2021) — Phenotypic, Nutritional, and Antioxidant Characterization of Blanched Oenanthe javanica for Preferable Cultivar. · Frontiers in plant science