Ominaeoshi (Patrinia scabiosifolia): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Patrinia scabiosifolia work as an anti-inflammatory?

Patrinia scabiosifolia exerts its anti-inflammatory effects primarily through its active compounds, including patrinoside, scabiosides, and oleanolic acid. These constituents have been shown to inhibit the production of pro-inflammatory cytokines and modulate immune responses. Additionally, the herb demonstrates antibacterial properties, helping to clear infections that cause inflammation. While these mechanisms are supported by pharmacological studies, clinical evidence remains limited (Evidence Level C).

Is Patrinia scabiosifolia safe to use during pregnancy?

No, Patrinia scabiosifolia is considered unsafe for use during pregnancy and is strictly contraindicated. In traditional Kampo medicine, this herb is known to promote blood circulation and clear stagnation, actions which may stimulate uterine contractions and potentially lead to miscarriage. Women who are pregnant or attempting to conceive should avoid this herb entirely. There is insufficient data regarding safety during breastfeeding, so avoidance is also recommended.

What is the standard dosage for Ominaeoshi root?

The standard adult dosage for Ominaeoshi depends on the preparation form. For a dried root decoction, the typical dosage ranges from 9 to 15 grams daily. If using a standardized extract, a common dosage is approximately 500 mg. Due to the potency of this herb and its specific indications for suppurative conditions, it is best to follow the guidance of a qualified herbalist or healthcare provider for personalized dosing.

Does Patrinia scabiosifolia interact with any medications?

Currently, there are no well-documented severe drug interactions for Patrinia scabiosifolia in standard pharmaceutical databases. However, because the herb is used for liver detoxification and possesses distinct biological activity, it may theoretically interact with liver-processed medications or immunosuppressants. Patients taking prescription medications should consult a healthcare provider before use. Evidence regarding specific interactions remains limited (Evidence Level D).

What is Ominaeoshi used for in Kampo medicine?

In Kampo medicine, Ominaeoshi is primarily used to treat suppurative infections and inflammatory conditions. It is valued for its ability to clear 'toxic heat' and resolve abscesses, boils, and swellings. The herb is also utilized to support liver function and detoxification. While traditional use is well-established, clinical evidence supporting these specific applications is currently rated as Level C, indicating a need for more rigorous research.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 13 articles PubMed · modèle : gemma4:31b

Résumé

Patrinia scabiosifolia is a medicinal herb used in traditional East Asian medicine for treating various inflammatory-related diseases [PMID:34299477, PMID:28347830].

Contexte

Patrinia scabiosifolia (PS) is a member of the Caprifoliaceae family [PMID:28347830] and is closely related to Patrinia monandra and Patrinia villosa [PMID:36051369]. It has been used in traditional medicine in East Asia, Africa, and South America for over 2000 years [PMID:38164833].

Usages traditionnels

Traditionally used in folk medicines to treat inflammatory diseases such as acute appendicitis, ulcerative colitis, and pelvic inflammation in Korea and other parts of East Asia [PMID:28347830].

Composés actifs

Active compounds include iridoid glucosides (such as patriniscabiosides A and B) [PMID:34299477], lignans (including patrinianeolignan I and eudesmin) [PMID:32743961], monoterpenes (such as patriniaol A) [PMID:32743961], γ-pyrone derivatives [PMID:32743961], triterpenoid saponins [PMID:22375871], and the flavonoid acacetin [PMID:34483900].

Mécanisme d'action

Anti-inflammatory effects are mediated through the inhibition of the NF-κB pathway [PMID:34299477] and the inhibition of the IL-17/CCL2 pathway and oxidative stress [PMID:39991764]. It promotes skin regeneration by increasing phosphorylation of Akt and Erk1/2 in human keratinocytes [PMID:31250551]. Against methicillin-resistant Staphylococcus epidermidis (MRSE), it damages the cell wall and membrane and involves β-lactamase, energy metabolism, and the antioxidant system [PMID:36925724].

Preuves cliniques

Preuve DInflammatory skin diseases (Atopic Dermatitis)

PS extract inhibited the production of IL-8 and TARC in human keratinocytes and reduced AD-like lesions in NC/Nga mice [PMID:28347830].

Preuve DSolar Dermatitis (UVB-induced)

Combined extracts of Portulaca oleracea and Patrinia scabiosaefolia diminished UVB-induced inflammation and erythema in mice [PMID:39991764].

Preuve DPsycho-emotional stress/Anxiety

Dry extract of P. scabiosifolia demonstrated anxiolytic and sedative properties in male mice under acoustic stress [PMID:38164833].

Preuve DHCT-116 Cancer Cells

Compounds patriniaol A and eudesmin exhibited moderate cytotoxicity against HCT-116 cells in vitro [PMID:32743961].

Preuve DMethicillin-resistant Staphylococcus epidermidis (MRSE)

P. scabiosaefolia showed strong antibacterial activity by damaging the cell wall and membrane [PMID:36925724].

Sécurité et effets indésirables

A study on dry extract in experimental animals reported that the effectiveness and safety of the herbal preparation were proven [PMID:38164833].

Synthèse des preuves

The current evidence is based primarily on in vitro studies and animal models (Level D), demonstrating potent anti-inflammatory, antibacterial, and anxiolytic activities. No human clinical trials were provided in the abstracts.

Sources PubMed

1.PMID: 33424592 (2020) — A Systematic Study of Mechanism of Sargentodoxa cuneata and Patrinia scabiosifolia Against Pelvic Inflammatory Disease With Dampness-Heat Stasis Syndrome via Network Pharmacology Approach. · Frontiers in pharmacology
2.PMID: 34299477 (2021) — Two New Iridoid Glucosides from the Whole Plant of Patrinia scabiosifolia Link. · Molecules (Basel, Switzerland)
3.PMID: 38164833 (2023) — Evaluation of the anxiolytic activity of dry extract of Patrinia scabiosifolia under acoustic stress. · European review for medical and pharmacological sciences
4.PMID: 31250551 (2019) — Chemical Composition of Patrinia scabiosifolia Flower Absolute and Its Migratory and Proliferative Activities in Human Keratinocytes. · Chemistry & biodiversity
5.PMID: 28347830 (2017) — Inhibitory effect of Patrinia scabiosifolia Link on the development of atopic dermatitis-like lesions in human keratinocytes and NC/Nga mice.

Ominaeoshi

Sources et citations

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