Passiflora alata (Passiflora alata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Passiflora alata work for anxiety?

Passiflora alata contains flavonoids including chrysin, vitexin, orientin, and luteolin that modulate GABA receptors in the brain. These compounds enhance GABA activity, producing calming and sedative effects similar to conventional anxiolytics. The herb's anti-inflammatory properties may also contribute to its therapeutic effects. Research on the specific mechanism remains limited. Evidence level: C.

Can I take Passiflora alata with other medications?

Passiflora alata interacts with central nervous system depressants including benzodiazepines, barbiturates, and alcohol. Combining it with sedatives may cause additive drowsiness and excessive sedation. It may also interact with antidepressants and antianxiety medications. Consult a healthcare provider before combining with prescription medications, especially those affecting the nervous system. Evidence level: C.

What is the recommended dosage for Passiflora alata?

Adults typically take Passiflora alata as tea prepared with 5-10 grams of dried leaves per cup, consumed up to three times daily. Capsule formulations are commonly dosed at 200mg three times daily. Dosage varies by product strength and concentration. Follow product label instructions and consult a qualified healthcare practitioner for personalized recommendations. Evidence level: Traditional.

Is Passiflora alata safe during pregnancy?

No, Passiflora alata is contraindicated during pregnancy. The herb's sedative compounds may affect fetal development and uterine activity. Pregnant women should avoid this herb entirely. Safety during breastfeeding has not been established, so lactating women should also avoid it. Evidence level: C, based on pharmacological activity and traditional contraindications.

What are the side effects of Passiflora alata?

Common side effects include drowsiness and mild gastrointestinal effects such as nausea or stomach discomfort. These effects are generally mild and reversible upon discontinuation. Avoid driving or operating machinery until you know how the herb affects you. Discontinue use if allergic reactions or severe symptoms occur. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Passiflora alata is a native South American flowering plant used in folk medicine as a sedative and tranquilizer [PMID:11268119, 15619554]. It is also commercially valued for its edible fruit [PMID:25117349, 38674353].

Contexte

Passiflora alata is a native flowering plant from the Amazon, geographically spread from Peru to Brazil [PMID:33092066]. It is an official species of the Brazilian Pharmacopoeia since 1929 [PMID:33092066, 19799991].

Usages traditionnels

Used in folk medicine as sedatives and tranquilizers [PMID:11268119, 15619554, 19799991].

Composés actifs

The plant contains polyphenols, flavonoids (including vitexin, isoorientin, rutin, and catechin), tannins, and saponins [PMID:27385958, 36009222, 15619554]. Aroma components include linalool and beta-ionone [PMID:35561053, 27598839].

Mécanisme d'action

Aqueous leaf extracts modulate bone marrow-derived professional antigen-presenting cells (BM-pAPCs) by decreasing the expression of indoleamine 2,3-dioxygenase (IDO) and CD86, which polarizes T cells to a Treg profile [PMID:35202987].

Preuves cliniques

Preuve DAnxiety

Hydroethanol and aqueous extracts induced anxiolytic-like effects in rats without affecting memory processes [PMID:11268119, 18598170]

Preuve DInflammation

Aqueous leaf extracts inhibited leukocyte migration and reduced exudate formation in mouse models of carrageenan-induced pleurisy [PMID:17215089]

Preuve DType 1 Diabetes (NOD mice)

Aqueous leaf extract decreased diabetes incidence, reduced infiltrative cells in pancreatic islets, and increased glutathione in the kidney and liver [PMID:24269180]

Preuve DTumor Proliferation

Leaf extract (PaLE) showed antitumor activity in S180-tumor bearing mice, with cell proliferation inhibition > 75% in several cell lines [PMID:33092066]

Preuve DSedation

Aqueous extracts from the pericarp and leaves decreased locomotor activity in mice in a dose-dependent manner [PMID:23893399]

Sécurité et effets indésirables

Acute toxicity tests in mice showed no deaths up to 4800 mg/kg p.o. [PMID:19799991]. However, antitumor treatments (100-150 mg/kg/day) were associated with reduced body mass, reduced food consumption, and increased spleen mass with histopathological changes in white pulp [PMID:33092066]. Rats treated with 300 mg/kg p.o. for 14 days showed signs of irritability [PMID:19799991].

Synthèse des preuves

The evidence consists primarily of in vitro studies and animal models (rats/mice), indicating potential anxiolytic, anti-inflammatory, and antioxidant properties. There are no human clinical trials provided in the abstracts.

Sources PubMed

1.PMID: 25117349 (2014) — Analysis of transferability of microsatellite primers (SSR) in wild Passiflora species and intraspecific genetic diversity in Passiflora alata. · Genetics and molecular research : GMR
2.PMID: 27385958 (2012) — Biological activities of extracts from cultivated Granadilla Passiflora alata. · EXCLI journal
3.PMID: 35561053 (2022) — Elucidation of aroma compounds in passion fruit (Passiflora alata Ait) using a molecular sensory approach. · Journal of food biochemistry
4.PMID: 38674353 (2024) — Cytogenomic Characterization of Transposable Elements and Satellite DNA in Passiflora L. Species. · Genes
5.PMID: 11268119 (2001) — Comparative pharmacological study of hydroethanol extracts of Passiflora alata and Passiflora edulis leaves. · Phytotherapy research : PTR

Passiflora alata

Sources et citations

Calculer une dose sûre de Passiflora alata