What is Piper sarmentosum (Piper sarmentosum) used for?

Piper sarmentosum (Piper sarmentosum) is traditionally used for troubles digestifs, paludisme, toux. Always consult a healthcare professional before use.

Is Piper sarmentosum safe during pregnancy?

Piper sarmentosum is generally considered safe during pregnancy, but always consult your healthcare provider.

Does Piper sarmentosum interact with medications?

Piper sarmentosum has no well-documented major drug interactions in our database, but always inform your healthcare provider about all supplements you take.

What are the side effects of Piper sarmentosum?

Recommended adult dosage: 10–30 g fresh leaves or 3–6 g dried leaves daily, preferably with food.. Generally safe at food doses; mild gastrointestinal upset possible with excessive intake.. Avoid large doses during pregnancy despite traditional safe use; high doses may stimulate uterine contractions.

Piper sarmentosum (Piper sarmentosum)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Piper sarmentosum is a traditional Southeast Asian medicinal and culinary plant with demonstrated antioxidant and anti-inflammatory properties [PMID:36453484, PMID:24107234].

Contexte

Piper sarmentosum Roxb. (Piperaceae) is an edible medicinal plant widely distributed in India, Malaysia, Thailand, and southeastern coastal areas of China [PMID:32620264, PMID:36091787].

Usages traditionnels

It has been used for centuries to treat wind-cold cough, fever, rheumatism arthralgia, diarrhea dysentery, postpartum foot swelling, stomachache, toothache, diabetes, traumatic injury, inflammation, dermatitis, joint pain, hypertension, and gastric ailments [PMID:32620264, PMID:24107234, PMID:36091787, PMID:40882786].

Composés actifs

Identified compounds include flavonoids such as naringenin [PMID:24107234], amide alkaloids (including pipersarmenoids A-F, pellitorine, and sarmentine) [PMID:38906388], and oroxylin A [PMID:37755961]. Other metabolites include lignans, phenylpropanoids, and aporphines [PMID:38743199].

Mécanisme d'action

The herb exhibits antioxidant and anti-inflammatory activities [PMID:36453484]. It may protect bone by acting as a superoxide scavenger via naringenin [PMID:24107234] and inhibit the Angiotensin-Converting Enzyme (ACE) pathway to exert antihypertensive effects [PMID:38474055]. Pellitorine may alleviate cognitive deficits by inhibiting neural inflammation and ferroptosis [PMID:40609205].

Preuves cliniques

Preuve COsteoporosis and Fracture Healing

Prevented deterioration of bone histomorphometric indices and promoted fracture healing in animal models of osteoporosis induced by ovariectomy and glucocorticoids [PMID:36453484, PMID:21789393].

Preuve AHypertension and Diabetes Mellitus

Traditionally used for these conditions; systematic review and meta-analysis conducted to evaluate effects [PMID:36091787].

Preuve DStress-Induced Gastric Ulcers

Methanolic extract (500 mg/kg) was as effective as omeprazole in preventing gastric lesions in rats by modulating oxidative stress and inflammation [PMID:36712695, PMID:30697274].

Preuve DVascular Endothelial Dysfunction

Aqueous leaf extract (250 mg/kg/day) improved vasorelaxation and vascular nitric oxide levels in nicotine-induced rats [PMID:34194328].

Preuve DCognitive Deficits (CRS)

Pellitorine treatment significantly alleviated depression-like behaviors and improved cognitive function in chronic restraint stress mouse models [PMID:40609205].

Synthèse des preuves

The majority of evidence is derived from animal models, in vitro studies, and literature reviews. While there is a systematic review/meta-analysis regarding hypertension and diabetes, most specific therapeutic claims are supported by preclinical data (Level C and D).

Sources PubMed

1.PMID: 36453484 (2023) — Effects of Piper sarmentosum on Bone Health and Fracture Healing: A Scoping Review. · Endocrine, metabolic & immune disorders drug targets
2.PMID: 24107234 (2013) — Piper sarmentosum: a new hope for the treatment of osteoporosis. · Current drug targets
3.PMID: 36091787 (2022) — Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis. · Frontiers in pharmacology
4.PMID: 32620264 (2020) — Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. · Journal of ethnopharmacology
5.PMID: 38906388 (2024) — Pipersarmenoids, new amide alkaloids from Piper sarmentosum.

Piper sarmentosum

Sources et citations

Acacia nilotica

Salvia pratensis

Picao Preto

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Piper sarmentosum

Sources et citations

Plantes associées

Acacia nilotica

Salvia pratensis

Picao Preto

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales