Polygonum Aviculare Herb (Polygonum aviculare): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Polygonum aviculare work for kidney stones?

Polygonum aviculare contains bioactive flavonoids, particularly avicularin and quercetin, which provide diuretic and anti-inflammatory effects. The herb's silica content helps strengthen urinary tract connective tissue. Its diuretic action increases urine volume, potentially helping flush small stones and prevent crystal formation. Additionally, caffeic acid contributes antioxidant and mild antimicrobial properties. These mechanisms support its traditional use for urinary stones, though evidence level C is based on ethnopharmacological data and in vitro studies rather than clinical trials.

Is Polygonum aviculare safe during pregnancy?

Polygonum aviculare is considered unsafe during pregnancy and should be avoided. The herb's diuretic properties and potential uterine effects pose risks during pregnancy. Some Polygonum species contain compounds that may stimulate uterine contractions. Breastfeeding women should also avoid this herb due to insufficient safety data. Women who are pregnant, planning pregnancy, or breastfeeding should consult a qualified healthcare provider before using any herbal remedies. This contraindication is based on traditional knowledge and pharmacological reasoning (Evidence level C).

What is the recommended dosage for Polygonum aviculare?

The typical adult dosage for Polygonum aviculare is 3-6 grams of dried herb prepared as a tea, taken up to three times daily. Alternatively, 4ml of tincture can be used daily. For urinary stone support, the herb is often consumed as an infusion. Always start with the lower dosage range to assess tolerance. Do not exceed recommended amounts without professional guidance. These recommendations are based on traditional use (Evidence level C) rather than standardized clinical trials.

Does Polygonum aviculare interact with medications?

Polygonum aviculare may interact with diuretic medications, as its natural diuretic properties could enhance effects and increase dehydration or electrolyte imbalance risks. Due to increased urination, it may affect how quickly certain drugs are eliminated from the body. Those taking lithium should exercise caution, as diuresis can alter lithium levels and potentially cause toxicity. Always consult a healthcare provider before combining this herb with prescription medications. Evidence level C is based on pharmacological reasoning rather than documented interaction studies.

What are the traditional uses of Polygonum aviculare?

Polygonum aviculare, commonly known as knotgrass, has been used across European, Traditional Chinese Medicine, and Native American healing traditions. European folk medicine employs it primarily for urinary stones and kidney support. In respiratory applications, it serves as an expectorant for coughs. Native American traditions used it topically for wound healing due to its astringent properties. The herb also demonstrates mild antimicrobial and anti-inflammatory effects. Current evidence level C supports these traditional applications, derived from ethnobotanical records and preliminary pharmacological studies.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 29 articles PubMed · modèle : gemma4:31b

Résumé

Polygonum aviculare L. (common knotgrass) is an annual herbaceous plant with demonstrated antioxidant, anti-inflammatory, and enzyme-inhibitory properties [PMID:16874403, 39683107, 31792306].

Contexte

Polygonum aviculare L., also known as common knotgrass or prostrate knotweed, is an annual herbaceous weed found in temperate regions worldwide [PMID:26047342, 35464762]. It is a member of the Polygonaceae family [PMID:26929003, 31644102].

Usages traditionnels

It has been used as a traditional folk medicine in Asian, African, Latin American, and Middle Eastern countries to treat inflammatory diseases such as arthritis and airway inflammation [PMID:39683107]. It is also known to be beneficial for treating gastroduodenal ulcer, hypertension, diarrhea, hemorrhage, and hemorrhoids [PMID:24270289], and is widely used in traditional Chinese medicine to treat urinary stones [PMID:41679836].

Composés actifs

Active constituents include flavonol-3-O-glycosides, flavonol-3-O-(2''-galloyl)-glycosides, and flavonol aglycones [PMID:31792306]. Specific identified compounds include quercetin, quercitrin hydrate, caffeic acid, rutin [PMID:26929003], hyperoside [PMID:35566359], and flavonol glucuronides [PMID:26047342, 24028968]. Essential oils contain (E)-β-farnesene, dodecanal, and β-caryophyllene [PMID:36558187]. A novel rhamnogalacturonan I (RG-I) pectin named PAPN1 has also been isolated [PMID:41679836].

Mécanisme d'action

The herb may mediate anti-inflammatory activity through the induction of heme oxygenase-1 (HO-1) and inhibition of inducible nitric oxide synthase (iNOS) [PMID:39683107]. It has been shown to activate the Wnt/β-catenin pathway to induce cutaneous wound healing [PMID:26929003]. In airway smooth muscle, it inhibits precontraction via L-type voltage-dependent Ca2+ channels (LVDCCs), TRPC3, and/or STIM/Orai channels [PMID:29449621]. It also inhibits porcine pancreatic lipase by inducing tertiary structural changes in the enzyme [PMID:31792306].

Preuves cliniques

Preuve DNephrolithiasis (Urinary stones)

Oral administration of isolated PAPN1 (10, 20, and 40 mg/kg/day) significantly reduced renal calcium oxalate crystal deposition in a dose-dependent manner and improved renal function in vivo [PMID:41679836]

Preuve DCutaneous wounds

Extract efficiently re-epithelized wounds generated on mice by accelerating the migration of HaCaT keratinocytes [PMID:26929003]

Preuve DChronic fatigue/Neuroinflammation

Extract reduced fatigue and attenuated symptoms in a mouse model of restraint stress [PMID:29655685]

Preuve DAirway smooth muscle contraction

Extract and quercetin inhibit precontraction in mouse and human airway smooth muscle [PMID:29449621]

Preuve DEMF-induced sperm damage

Herbal extract (50 mg/kg) was evaluated for its ability to diminish hazardous effects of EMF exposure in mice [PMID:22308654]

Synthèse des preuves

The current evidence consists primarily of in vitro studies and animal models (Level D), demonstrating significant pharmacological potential in anti-inflammatory, antioxidant, and wound-healing activities. No human clinical trials were provided in the source abstracts.

Sources PubMed

1.PMID: 31644102 (2012) — The genome sequence of common knotgrass, Polygonum aviculare L. (Polygonaceae). · CITED REFERENCE
2.PMID: 31792306 (2019) — Inhibitory characteristics of flavonol-3-O-glycosides from Polygonum aviculare L. (common knotgrass) against porcine pancreatic lipase. · Scientific reports
3.PMID: 29449621 (2018) — Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle. · Scientific reports
4.PMID: 39683107 (2024) — Hydroethanolic Extract of Polygonum aviculare L. Mediates the Anti-Inflammatory Activity in RAW 264.7 Murine Macrophages Through Induction of Heme Oxygenase-1 and Inhibition of Inducible Nitric Oxide Synthase. · Plants (Basel, Switzerland)
5.PMID: 35464762 (2022) — Antioxidant Molecules Isolated from Edible Prostrate Knotweed: Rational Derivatization to Produce More Potent Molecules.

Polygonum Aviculare Herb

Sources et citations

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