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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Symphytum asperum
Caucasian comfrey species widely naturalized; used topically like common comfrey for wound healing and musculoskeletal injuries.
Prickly Comfrey (Symphytum asperum) is a Caucasian species of comfrey naturalized in many regions, used topically for wound healing and musculoskeletal injuries. Its key active compounds include allantoin (promotes cell proliferation), rosmarinic acid (anti-inflammatory), and pyrrolizidine alkaloids (hepatotoxic). Evidence level B supports its topical use for wound healing and inflammation, but internal use is contraindicated due to hepatotoxicity.
Allantoin stimulates fibroblast proliferation and collagen synthesis, accelerating wound closure and tissue regeneration. Rosmarinic acid inhibits cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), reducing prostaglandin and leukotriene production, thereby exerting anti-inflammatory effects. Mucilage forms a protective film over wounds, promoting moist healing. Pyrrolizidine alkaloids (PAs) are hepatotoxic via metabolic activation to reactive metabolites that cause veno-occlusive disease; thus only PA-free topical preparations are considered safe.
Caucasian comfrey species widely naturalized; used topically like common comfrey for wound healing and musculoskeletal injuries.
Prickly Comfrey (Symphytum asperum) is a Caucasian species of comfrey naturalized in many regions, used topically for wound healing and musculoskeletal injuries. Its key active compounds include allantoin (promotes cell proliferation), rosmarinic acid (anti-inflammatory), and pyrrolizidine alkaloids (hepatotoxic). Evidence level B supports its topical use for wound healing and inflammation, but internal use is contraindicated due to hepatotoxicity.
Allantoin stimulates fibroblast proliferation and collagen synthesis, accelerating wound closure and tissue regeneration. Rosmarinic acid inhibits cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), reducing prostaglandin and leukotriene production, thereby exerting anti-inflammatory effects. Mucilage forms a protective film over wounds, promoting moist healing. Pyrrolizidine alkaloids (PAs) are hepatotoxic via metabolic activation to reactive metabolites that cause veno-occlusive disease; thus only PA-free topical preparations are considered safe.