Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Rauvolfia vomitoria lower blood pressure?
Rauvolfia vomitoria works primarily through its reserpine content, which depletes catecholamines (norepinephrine, epinephrine, and dopamine) from nerve terminals. This depletion reduces sympathetic nervous system activity, leading to vasodilation and decreased heart rate. The result is a gradual but sustained reduction in blood pressure. Reserpine also depletes serotonin in the brain, contributing to its sedative effects on mental conditions. Evidence level: C.
What are the drug interactions of Rauvolfia vomitoria?
Rauvolfia vomitoria has significant drug interactions due to its reserpine content. It should not be combined with MAO inhibitors, other antihypertensive medications, digitalis, or CNS depressants. Concurrent use with antidepressants may reduce efficacy. The herb can potentiate effects of blood pressure medications, causing dangerous hypotension. Patients taking any prescription medications should consult a physician before use. Evidence level: C.
What is the correct dosage for Rauvolfia vomitoria?
Rauvolfia vomitoria should only be used under direct physician supervision. There is no established safe self-medication dosage due to variable alkaloid content between plants and the narrow therapeutic window of reserpine. Traditional preparations vary considerably in strength. The potential for serious side effects, including severe depression and cardiac complications, necessitates professional medical oversight for appropriate dosing. Evidence level: C.
Is Rauvolfia vomitoria safe during pregnancy?
No, Rauvolfia vomitoria is unsafe during pregnancy and is contraindicated. The active alkaloids, particularly reserpine, cross the placenta and may cause fetal harm including bradycardia, respiratory distress, and hypothermia in newborns. The herb may also stimulate uterine contractions. Women who are pregnant, planning pregnancy, or breastfeeding should avoid this herb entirely. Evidence level: C.
What are the side effects of Rauvolfia vomitoria?
Common side effects include depression (a serious concern due to serotonin depletion), nasal congestion, gastrointestinal disturbances, fatigue, and bradycardia. More severe effects can include hypotension, weight gain, and exacerbation of Parkinson's disease symptoms. Depression caused by reserpine can persist for months after discontinuation. This herb is contraindicated in patients with history of depression, Parkinson's disease, or cardiac conditions. Evidence level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Rauvolfia vomitoria is a medicinal plant used in traditional African and Asian medicine for various conditions, including psychosis, diabetes, and hypertension [PMID:34592080, 33470534, 34335835].
Contexte
Rauvolfia vomitoria is an ethno-botanical plant widely distributed in tropical regions of Africa and Asia [PMID:37216495, 33470534].
Usages traditionnels
Traditional uses include the management of several human diseases, specifically psychosis [PMID:34592080], hypertension [PMID:34335835], infectious diarrhea [PMID:34007296], malaria [PMID:15814260], and the enhancement of male sexual and reproductive activity [PMID:31692024]. It is also used in Nigerian traditional medicine to treat type 2 diabetes, often as a tea combined with Citrus aurantium [PMID:38744382].
Composés actifs
The plant contains monoterpene indole alkaloids, including reserpine, yohimbine, ajmaline, ajmalicine, and serpentine [PMID:33470534, 27437669]. Specific isolated alkaloids include rauvomitorine A-I, rauvines A and B, and rauvomine A-G [PMID:32580106, 33044757, 32827693]. Phenolic components and alpha-amyrin palmitate have also been identified [PMID:37216495, 7475126].
Mécanisme d'action
In vitro studies show inhibition of acetylcholinesterase (AChE), arginase, and ACE [PMID:37216495, 32738570]. It exhibits anti-diabetic activity through the inhibition of alpha-amylase and alpha-glucosidase [PMID:40156817]. Additionally, it demonstrates antioxidant properties, reducing free radicals and inhibiting lipid peroxidation [PMID:34592080].
Preuves cliniques
Preuve DType 2 Diabetes
Rauvolfia-Citrus tea causes normalization of blood glucose and reduction of ectopic lipid accumulation in genetic diabetic mice and humans with T2D [PMID:38744382].
Preuve DSeizures
Phenol extract relieved pentylenetetrazol-induced seizures and protected temporal lobe structures in Swiss mice [PMID:40217363].
Preuve DColorectal Cancer
Total alkaloids (RVA) acted as a chemosensitizer for 5-fluorouracil, significantly reducing final tumor weight in mice [PMID:36174417, 36688051].
Preuve DSexual Performance
Ethanolic extract enhanced sexual behavior and reproductive function in male rats [PMID:31692024].
Preuve DInflammation/Arthritis
A combination of R. vomitoria root bark with other plants suppressed carrageenin-induced edema and reduced ankle swelling in rats [PMID:1921424, 1943160].
Preuve DMalaria
Ethanolic extracts showed significant antiplasmodial activity against chloroquine-resistant Plasmodium falciparum in vitro [PMID:15814260].
Sécurité et effets indésirables
R. vomitoria root bark may adversely affect the brain functionally and structurally, as evidenced by decreased grooming frequency and altered amygdala microstructure in mice [PMID:32006225]. Acute toxicity tests at 2000 mg/kg in the Beninese flora study were conducted, though specific adverse outcomes for R. vomitoria were not detailed in the abstract [PMID:34007296].
Interactions médicamenteuses
R. vomitoria total alkaloids (RVA) exhibit synergistic effects with 5-fluorouracil in colorectal cancer therapy [PMID:36174417] and certain sarpagine-type alkaloids show synergy with cisplatin against ovarian cancer cells [PMID:41313936, 42308054].
Synthèse des preuves
The current evidence is primarily based on in vitro assays and animal models (Level D), with limited mention of human application in traditional tea formulations. No high-level clinical trials (RCTs) or systematic reviews were provided.
Sources PubMed
1.PMID: 37216495 (2023) — Chemical composition, antioxidant, and enzyme inhibitory properties of Rauwolfia vomitoria extract. · Journal of complementary & integrative medicine
2.PMID: 40217363 (2024) — Rauvolfia vomitoria phenol extract relieves pentylenetetrazol-induced seizures in Swiss mice and protects some temporal lobe structures. · Acta epileptologica
3.PMID: 36688051 (2022) — Identification of chemosensitizing agents of colorectal cancer in Rauvolfia vomitoria using an NMR-based chemometric approach. · Frontiers in chemistry
4.PMID: 34592080 (2020) — Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat's brain in vitro. · Journal of basic and clinical physiology and pharmacology
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— In Vitro and In Vivo Investigation of the Antidiabetic Mechanisms of Action of Rauvolfia vomitoria leaf.
· Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
6.PMID: 31692024 (2020) — In vivo effects of Rauvolfia vomitoria (Apocynaceae) ethanolic extract on sexual performance and reproductive activity in male rats. · Andrologia
7.PMID: 32738570 (2020) — Monoterpene indole alkaloids with acetylcholinesterase inhibitory activity from the leaves of Rauvolfia vomitoria. · Bioorganic chemistry
8.PMID: 33044757 (2020) — Cytotoxic Yohimbine-Type Alkaloids from the Leaves of Rauvolfia vomitoria. · Chemistry & biodiversity
9.PMID: 36174417 (2022) — A serum metabolomics study based on LC-MS: Chemosensitization effects of Rauvolfia vomitoria Afzel. combined with 5- fluorouracil on colorectal cancer mice. · Journal of pharmaceutical and biomedical analysis
10.PMID: 32827693 (2020) — Peraksine derivatives with potential anti-inflammatory activities from the stems of Rauvolfia vomitoria. · Fitoterapia
11.PMID: 27157629 (2016) — Why ritual plant use has ethnopharmacological relevance. · Journal of ethnopharmacology
12.PMID: 38416335 (2024) — Characterization, Anti-glycation, Anti-inflammation, and Lipase Inhibitory Properties of Rauvolfia vomitoria Leaf Extract: In Vitro and In Silico Evaluations for Obesity Treatment. · Applied biochemistry and biotechnology
13.PMID: 32580106 (2020) — Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities. · Phytochemistry
14.PMID: 28718654 (2017) — Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria. · Organic letters
15.PMID: 33470534 (2021) — Simultaneous determination of five alkaloids from Rauvolfia vomitoria in rat plasma by LC-MS/MS: Application to a comparative pharmacokinetic study in normal and type 2 diabetic rats. · Journal of separation science
16.PMID: 38744382 (2024) — Standardization parameters and synergism of source plant materials for the antidiabetic efficacy of the Rauvolfia-Citrus tea. · Fitoterapia
17.PMID: 35596240 (2020) — Attenuation of potassium dichromate and sodium arsenite toxicities by methanol extract of Rauvolfia vomitoria in mice. · Journal of basic and clinical physiology and pharmacology
18.PMID: 42308054 (2026) — Diverse Monoterpene Indole Alkaloids with Unprecedented Chemical Architectures from Rauvolfia vomitoria and Their Potential as Cisplatin Sensitizers. · The Journal of organic chemistry
19.PMID: 41872917 (2026) — Diabetes mellitus in ECOWAS: an overview of the safety and efficacy of medicinal plants used in traditional medicine practices. · Tropical medicine and health
20.PMID: 32006225 (2020) — Murine's amygdala microstructure and elevated plus maze activities following R. vomitoria root bark and G. latifolium leaf extracts administration. · Anatomical science international
21.PMID: 34007296 (2021) — Toxicological Characterization of Ten Medicinal Plants of the Beninese Flora Used in the Traditional Treatment of Diarrheal Diseases. · Evidence-based complementary and alternative medicine : eCAM
22.PMID: 19619631 (2009) — Mutagenic screening of some commonly used medicinal plants in Nigeria. · Journal of ethnopharmacology
23.PMID: 35270103 (2022) — Ethnobotanical Survey of Local Flora Used for Medicinal Purposes among Indigenous People in Five Areas in Lagos State, Nigeria. · Plants (Basel, Switzerland)
24.PMID: 41313936 (2026) — SMART-guided discovery of Sarpagine-type monoterpene indole alkaloids from Rauvolfia vomitoria and the synergistic effects with cisplatin against human ovarian cancer cells. · Bioorganic chemistry
25.PMID: 27437669 (2016) — Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry. · Phytochemical analysis : PCA
26.PMID: 1921424 (1991) — Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: I. · Journal of ethnopharmacology
27.PMID: 1943160 (1991) — Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: II. · Journal of ethnopharmacology
28.PMID: 34335835 (2021) — Ethnopharmacological Survey on Treatment of Hypertension by Traditional Healers in Bukavu City, DR Congo. · Evidence-based complementary and alternative medicine : eCAM
29.PMID: 7475126 (1995) — Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: III. · Journal of ethnopharmacology
30.PMID: 15814260 (2005) — In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. · Journal of ethnopharmacology