Sang Shen (Morus alba (fruit)): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Sang Shen work in the body?

Sang Shen (mulberry fruit) contains active compounds including anthocyanins like cyanidin and pelargonidin, along with resveratrol and quercetin. These constituents provide antioxidant activity that helps neutralize free radicals and reduce oxidative stress. In Traditional Chinese Medicine, Sang Shen nourishes blood and enriches Yin, supporting the Liver and Kidney organ systems. This mechanism explains its traditional use for symptoms like dizziness, tinnitus, and constipation from dryness. Evidence level: C.

Does Sang Shen interact with any medications?

There are currently no well-documented drug interactions for Sang Shen in the scientific literature. However, due to its antioxidant properties and potential effects on blood glucose metabolism, individuals taking diabetes medications or anticoagulants should consult a healthcare provider before using therapeutic doses. Sang Shen may theoretically enhance the effects of laxatives due to its moistening properties. Always disclose all herbal supplements to your healthcare provider. Evidence level: C.

What is the recommended dosage for Sang Shen?

The standard adult dosage for Sang Shen is 9-15 grams of dried fruit daily, or 30-60 grams of fresh mulberry fruit daily. The dried fruit can be prepared as a decoction, taken in powdered form, or incorporated into food. For therapeutic use in TCM formulas, dosage may vary based on individual constitution and the specific condition being addressed. Consult a qualified herbalist for personalized recommendations. Evidence level: Traditional.

Is Sang Shen safe to take during pregnancy?

Sang Shen is generally considered safe during pregnancy when consumed in normal food amounts. In Traditional Chinese Medicine, it is classified as a gentle tonic herb that nourishes blood and enriches Yin without strong purging or moving actions that could disrupt pregnancy. However, pregnant women should consult a qualified healthcare provider before using concentrated or therapeutic doses. As with any herb during pregnancy, moderation and professional guidance are recommended. Evidence level: Traditional.

What is Sang Shen used for in TCM?

In Traditional Chinese Medicine, Sang Shen is used to nourish blood and enrich Yin, primarily supporting the Liver and Kidney organ systems. It is prescribed for Liver and Kidney Yin deficiency patterns manifesting as dizziness, tinnitus, premature graying of hair, and constipation from intestinal dryness. The fruit's moistening quality makes it particularly useful for dryness-related conditions. Modern research has identified antioxidant activity from its anthocyanin and resveratrol content. Evidence level: C.

What are the side effects of Sang Shen?

Sang Shen is generally well-tolerated, but side effects can occur in susceptible individuals. The most common adverse effect is diarrhea, particularly in those with weak Spleen function or pre-existing loose stools. For this reason, Sang Shen is contraindicated in cases of diarrhea and Spleen deficiency. Individuals with cold or weak digestion should use this herb with caution. Discontinue use if digestive upset occurs and consult a qualified herbalist.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Sang Shen (Morus alba fruit) is a traditional medicinal fruit from East Asia known for its diverse bioactivities, including antioxidant and neuroprotective effects [PMID:29129054, PMID:37111108].

Contexte

Morus alba L. is a member of the Moraceae family widely planted in Asia and used as both a food and a traditional medicine [PMID:29883416, PMID:29129054].

Usages traditionnels

It has been used in traditional medicine for thousands of years in East Asia to treat various infectious and internal ailments [PMID:37111108, PMID:36592613].

Composés actifs

Bioactive components include anthocyanins (specifically cyanidin 3-glucoside), rutin, quercetin, chlorogenic acid, polysaccharides, alkaloids, flavonoids, and resveratrol [PMID:29129054, PMID:29883416, PMID:24716151, PMID:39451250].

Mécanisme d'action

Mechanisms include the modulation of apoptotic pathways and matrix metalloproteinases (MMPs) to block cancer progression, activation of the Nrf2/ARE signaling pathway to protect against hepatocyte lipotoxicity, and inhibition of acetylcholinesterase (AChE) and oxidative stress to improve cognitive function [PMID:24716151, PMID:31537067, PMID:37597050].

Preuves cliniques

Preuve DCognitive Deficit/Memory Impairment

Morus alba fruit extract ameliorated cognitive deficits and memory impairment in streptozotocin-induced mouse models by modulating oxidative and cholinergic systems [PMID:36947332, PMID:37597050]

Preuve DGastrointestinal Motility

Morus alba fruit (MAF) accelerated intestinal transit rate in mice, suggesting potential as a prokinetic agent [PMID:37111108]

Preuve DHepatotoxicity

Mulberry fruit polysaccharides (MFP-II) attenuated palmitic acid-induced hepatic lipotoxicity in vitro [PMID:31537067]

Preuve DCisplatin-Induced Kidney Damage

Six identified phytosterols from M. alba fruit displayed protective effects against cisplatin-induced LLC-PK1 cell damage [PMID:34834844]

Preuve DSkin Hyperpigmentation

Mulberry fruit extracts are used as cosmetic skin-lightening agents due to their capacity to inhibit tyrosinase [PMID:40806718]

Sécurité et effets indésirables

Mulberry fruit can cause IgE-mediated allergic reactions, including generalized urticaria, chest tightness, breathing difficulty, and abdominal cramping in sensitized individuals [PMID:25729628].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), with several review articles (Level C) summarizing potential health benefits. There is a lack of human clinical trial data.

Sources PubMed

1.PMID: 37111108 (2023) — Prokinetic Activity of Mulberry Fruit, Morus alba L. · Nutrients
2.PMID: 29129054 (2017) — The Mulberry (Morus alba L.) Fruit-A Review of Characteristic Components and Health Benefits. · Journal of agricultural and food chemistry
3.PMID: 29883416 (2018) — Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review. · Antioxidants (Basel, Switzerland)
4.PMID: 24716151 (2013) — Mulberry ( sang shèn zǐ) and its bioactive compounds, the chemoprevention effects and molecular mechanisms in vitro and in vivo. · Journal of traditional and complementary medicine
5.PMID: 40806718 (2025) — Inhibition of Tyrosinase and Melanogenesis by a White Mulberry Fruit Extract. · International journal of molecular sciences

Sang Shen

Sources et citations

Calculer une dose sûre de Sang Shen

Coprosma Robusta

Cassia Senna

Porphyra umbilicalis

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Sang Shen

Sources et citations

Calculer une dose sûre de Sang Shen

Plantes associées

Coprosma Robusta

Cassia Senna

Porphyra umbilicalis

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales