How does Schisandra sphenanthera protect the liver?

Schisandra sphenanthera protects the liver through its lignan compounds, particularly schisantherin and gomisin. These constituents enhance glutathione synthesis, boost antioxidant enzyme activity, and inhibit lipid peroxidation in hepatocytes. The lignans also modulate cytochrome P450 enzymes and may promote liver cell regeneration. Traditional Chinese Medicine has used this herb for centuries as a hepatoprotective agent, though modern clinical evidence remains preliminary (Level C).

Can Schisandra sphenanthera interact with medications?

Yes, Schisandra sphenanthera may interact with medications metabolized by the liver. Its lignans can induce or inhibit cytochrome P450 enzymes, potentially altering blood levels of drugs including warfarin, cyclosporine, and certain statins. This interaction could increase toxicity or reduce efficacy of these medications. Patients taking prescription drugs should consult a healthcare provider before using Schisandra supplements. Evidence level: C, based on pharmacological studies.

What is the recommended dosage for Schisandra sphenanthera?

Traditional dosage for Schisandra sphenanthera is 3-9 grams of dried berries prepared as a decoction. Standardized extracts typically recommend 500mg daily. The herb is traditionally consumed as a tea or in powdered form. Dosage may vary depending on the specific preparation and intended use. Follow product label instructions or consult a qualified herbalist, as individual needs may differ. Evidence for optimal dosing is limited (Level C).

Is Schisandra sphenanthera safe during pregnancy?

No, Schisandra sphenanthera is contraindicated during pregnancy, particularly in early stages. The herb contains compounds that may stimulate uterine contractions and potentially affect fetal development. Traditional use and available evidence classify it as unsafe for pregnant women. Those who are pregnant, planning pregnancy, or breastfeeding should avoid this herb entirely. Consult a healthcare provider for safe alternatives. Safety classification: Level D.

What are the side effects of Schisandra sphenanthera?

Schisandra sphenanthera is generally well-tolerated, but some individuals may experience heartburn and gastrointestinal upset due to its sour, acidic nature. People with peptic ulcers should avoid this herb as it may irritate the gastric lining. Other reported effects include mild appetite changes and occasional headaches. Most adverse effects are mild and resolve with discontinuation. Start with lower doses to assess tolerance. Evidence level: C.

Schisandra Sphenanthera (Schisandra sphenanthera)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Schisandra sphenanthera is a medicinal herb from the Magnoliaceae family, primarily grown in southern China, Taiwan, and Vietnam, used for various therapeutic purposes [PMID:34559620].

Contexte

Schisandra sphenanthera (S. sphenanthera), also known as Nan-Wuweizi, is a species of the Schisandra genus in the Magnoliaceae family [PMID:34559620, PMID:18849034]. It is often used as a restorative, tonic, and nutritional supplement [PMID:27813307].

Usages traditionnels

Traditionally used for the treatment of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, insomnia [PMID:34559620], coughs, palpitation, and spermatorrhea [PMID:34678416]. It is also used for 'thirst-quenching' related to diabetes mellitus [PMID:40471999, PMID:39740377].

Composés actifs

Approximately 310 natural constituents have been isolated, including lignans (such as Schisandrol B and anwulignan), triterpenes, volatile oils, and polysaccharides [PMID:34559620, PMID:39809031, PMID:34131018].

Mécanisme d'action

Bioactive compounds like Schisandrol B regulate bile acid homeostasis via the pregnane X receptor (PXR) [PMID:39809031]. Other mechanisms include the modulation of sweet taste receptor pathways, IRS/PI3K, and AMPK/mTOR pathways in the context of diabetes [PMID:39740377].

Preuves cliniques

Preuve DNon-alcoholic fatty liver disease (NAFLD)

Wuzhi capsule (S. sphenanthera extract) attenuated liver steatosis and inflammation in a mouse model [PMID:30522014]

Preuve DIntestinal Ischemia/Reperfusion (II/R)

Oral anwulignan increased mesenteric blood microcirculatory flow velocity and reduced pathologic injury of the jejunum in rats [PMID:34131018]

Preuve DDepression-like behavior

Schisandrol B alleviated depression-like behavior in mice by regulating the brain-liver-gut axis [PMID:39809031]

Preuve DType 2 Diabetes Mellitus (T2DM)

Petroleum ether extracts and other fractions prevented hyperglycemia and insulin resistance in rat models [PMID:38718889, PMID:40471999]

Preuve DSARS-CoV-2

Ethanolic extracts and specific 7,8-secolignans potently inhibited SARS-CoV-2 3CLpro and inflammation in vitro [PMID:39262656]

Interactions médicamenteuses

S. sphenanthera can induce metabolic drug-drug interactions by inhibiting cytochrome P450 and P-glycoprotein activities [PMID:35359848]. It has been shown to alter the pharmacokinetics of tacrolimus in a dose- and time-dependent manner in rats [PMID:32768638], and negative treatment outcomes may occur when taken concurrently with common cancer treatments [PMID:36707434].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D) and comprehensive reviews (Level C), with a lack of human clinical trial data in the provided abstracts.

Sources PubMed

1.PMID: 34559620 (2021) — Schisandra sphenanthera: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications. · The American journal of Chinese medicine
2.PMID: 18849034 (2009) — Analysis of Schisandra chinensis and Schisandra sphenanthera. · Journal of chromatography. A
3.PMID: 39809031 (2025) — Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor. · Phytomedicine : international journal of phytotherapy and phytopharmacology
4.PMID: 34678416 (2022) — A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils. · Journal of ethnopharmacology
5.PMID: 29352909

Schisandra Sphenanthera

Sources et citations

Prunus serotina

Xiao Yao San Patent

Pfaffia Paniculata

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Schisandra Sphenanthera

Sources et citations

Plantes associées

Prunus serotina

Xiao Yao San Patent

Pfaffia Paniculata

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales