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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Paeonia + Glycyrrhiza Kampo
Japanese Kampo two-herb formula for muscle cramps and PCOS.
Kampo Shakuyaku-kanzo-to is a traditional Japanese two-herb formula combining Paeonia lactiflora and Glycyrrhiza glabra, standardized for paeoniflorin and glycyrrhizin content. It is primarily used for muscle cramps, spasms, and abdominal pain, and has emerging applications in polycystic ovary syndrome (PCOS) due to its anti-androgenic effects. The formula exhibits antispasmodic, anti-inflammatory, and hormone-modulating activities, but its use is limited by risks of pseudoaldosteronism and hypokalemia from glycyrrhizin.
Paeoniflorin exerts antispasmodic effects by modulating calcium channels and enhancing GABA-A receptor activity, reducing neuronal excitability and smooth muscle contraction. Glycyrrhizin and its metabolite glycyrrhetinic acid inhibit 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), increasing local cortisol availability and causing mineralocorticoid-like effects (pseudoaldosteronism). Additionally, glycyrrhetinic acid inhibits 5α-reductase and aromatase, reducing testosterone conversion to dihydrotestosterone and estrogen, thereby lowering androgen levels in PCOS. The combination also suppresses COX-2 and NF-κB pathways, contributing to anti-inflammatory and analgesic actions.
Japanese Kampo two-herb formula for muscle cramps and PCOS.
Kampo Shakuyaku-kanzo-to is a traditional Japanese two-herb formula combining Paeonia lactiflora and Glycyrrhiza glabra, standardized for paeoniflorin and glycyrrhizin content. It is primarily used for muscle cramps, spasms, and abdominal pain, and has emerging applications in polycystic ovary syndrome (PCOS) due to its anti-androgenic effects. The formula exhibits antispasmodic, anti-inflammatory, and hormone-modulating activities, but its use is limited by risks of pseudoaldosteronism and hypokalemia from glycyrrhizin.
Paeoniflorin exerts antispasmodic effects by modulating calcium channels and enhancing GABA-A receptor activity, reducing neuronal excitability and smooth muscle contraction. Glycyrrhizin and its metabolite glycyrrhetinic acid inhibit 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), increasing local cortisol availability and causing mineralocorticoid-like effects (pseudoaldosteronism). Additionally, glycyrrhetinic acid inhibits 5α-reductase and aromatase, reducing testosterone conversion to dihydrotestosterone and estrogen, thereby lowering androgen levels in PCOS. The combination also suppresses COX-2 and NF-κB pathways, contributing to anti-inflammatory and analgesic actions.