Sheng Di Huang (Rehmannia glutinosa): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Sheng Di Huang work in the body?

Sheng Di Huang works primarily through iridoid glycosides like catalpol and rehmannioside, which demonstrate anti-inflammatory and antioxidant properties in laboratory studies. In Traditional Chinese Medicine (TCM) theory, its mechanism involves nourishing Kidney and Liver yin while cooling the blood. Research suggests these compounds may support kidney function and regulate glucose metabolism, though human clinical trials are limited (Evidence Level: C).

Does Sheng Di Huang interact with prescription medications?

Sheng Di Huang may interact with antidiabetic medications because it can lower blood glucose levels, potentially causing hypoglycemia when combined with insulin or oral hypoglycemics. Due to its effects on the cardiovascular system, it may also potentiate the effects of anticoagulants or anti-platelet drugs. Patients taking these medications should consult a healthcare provider before use (Evidence Level: C).

What is the standard dosage for Sheng Di Huang?

The standard adult dosage for Sheng Di Huang is 10 to 30 grams of the dried root when prepared as a decoction. For concentrated extract forms, the typical dosage is 500 mg to 1 gram taken two to three times daily. Dosage varies based on the specific formulation, such as Liu Wei Di Huang Wan, and should be adjusted by a qualified practitioner (Evidence Level: Traditional).

Is Sheng Di Huang safe to take during pregnancy?

Sheng Di Huang is considered unsafe during pregnancy and is contraindicated, particularly in large doses. In TCM theory, its cooling and blood-invigorating properties may be inappropriate for pregnant patients and could potentially stimulate uterine activity. Women who are pregnant or breastfeeding should avoid this herb unless specifically prescribed by a qualified medical professional (Evidence Level: Traditional).

What are the side effects of taking Rehmannia glutinosa?

Common side effects of Sheng Di Huang include gastrointestinal upset, nausea, and diarrhea, particularly when taken in excessive amounts. Because the herb is cooling and moistening in nature, it can cause stagnation in individuals with weak digestion or Spleen-Stomach deficiency. Users should discontinue use if persistent digestive symptoms occur (Evidence Level: Traditional).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Sheng Di Huang (Rehmannia glutinosa) is a traditional Chinese medicinal herb known for its diverse pharmacological effects, including anti-inflammatory, antioxidant, and neuroprotective properties [PMID:37907043, PMID:18407446].

Contexte

Rehmannia glutinosa Libosch, belonging to the Scrophulariaceae family, is used as a traditional Chinese medicine (TCM) in the form of fresh or dried root tubers [PMID:37907043, PMID:18407446].

Usages traditionnels

It is traditionally used to nourish Yin, invigorate the kidney [PMID:18407446, PMID:37579922], clear heat, cool the blood [PMID:36634722], and control blood sugar in the treatment of diabetes [PMID:37539737].

Composés actifs

Active ingredients include iridoid glycosides (such as catalpol, aucuboside, and geniposide), phenylpropanoid glycosides (such as acteoside), polysaccharides, unsaturated fatty acids (such as oleic acid), and various amino acids and saccharides [PMID:37907043, PMID:34798521, PMID:18407446, PMID:31118959].

Mécanisme d'action

Mechanisms include the inhibition of the TGF-β1/MAPK signaling pathway for renal fibrosis [PMID:37579922], the Ras/MAPKs/PPAR-γ signaling pathway for acute kidney injury [PMID:34798521], the TLR4/MyD88/NF-κB pathway for diabetic nephropathy [PMID:40334822], and the activation of the STAT3 signaling pathway to promote cerebral organoid generation [PMID:40385540].

Preuves cliniques

Preuve APerimenopausal syndrome in breast cancer patients

Quantitative assessment of therapeutic effect using CHM with Rehmannia glutinosa as the main ingredient [PMID:40628433]

Preuve CDepression

Baihe Dihuang Decoction (containing Rehmannia glutinosa and Lilium lancifolium) is effective in treating depression [PMID:39539631]

Preuve CAlzheimer's and Parkinson's Diseases

Catalpol exhibits antioxidant, anti-inflammatory, and anti-apoptotic neuroprotective properties [PMID:25620103, PMID:35815283, PMID:34216649]

Preuve DDiabetic Nephropathy

Water extracts (RGW) ameliorate diabetic nephropathy in rats via the TLR4/MyD88/NF-κB pathway [PMID:40334822]

Preuve DAcute Liver Injury

Rehmannia glutinosa polysaccharide (RGP) demonstrates protective effects against LPS-induced liver injury in mice [PMID:40484254]

Synthèse des preuves

The evidence consists primarily of in vitro and animal studies (Level D) and literature reviews (Level C), with one systematic review/meta-analysis (Level A) regarding perimenopausal syndrome.

Sources PubMed

1.PMID: 37907043 (2023) — Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2.PMID: 34798521 (2022) — Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras/MAPKs/PPAR-γ signaling pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 18407446 (2008) — Rehmannia glutinosa: review of botany, chemistry and pharmacology. · Journal of ethnopharmacology
4.PMID: 37579922 (2024) — Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway. · Journal of ethnopharmacology
5.PMID: 36634722 (2023)

Sheng Di Huang

Sources et citations

Calculer une dose sûre de Sheng Di Huang

Ganoderma Tsugae

Rheum officinale

Physalis peruviana

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Sheng Di Huang

Sources et citations

Calculer une dose sûre de Sheng Di Huang

Plantes associées

Ganoderma Tsugae

Rheum officinale

Physalis peruviana

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales