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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Helleborus foetidus
Toxic evergreen perennial of European woodlands; historically used in minute doses as drastic purgative and for intestinal worms.
Helleborus foetidus (stinking hellebore) is a highly toxic perennial herb containing cardiac glycosides such as hellebrin and steroidal saponins. Historically employed in minute doses as a drastic purgative and anthelmintic, its use is now limited to ethnobotanical documentation and toxicological research due to severe gastrointestinal and cardiotoxic risks.
The primary active compounds, hellebrin and related bufadienolide glycosides, inhibit the Na+/K+-ATPase pump in cardiac myocytes, increasing intracellular sodium and subsequently calcium via the Na+/Ca2+ exchanger, leading to positive inotropy. Concurrently, protoanemonin and saponins cause severe mucosal irritation, resulting in violent purgation. The narrow therapeutic window and potential for fatal arrhythmias preclude any safe internal use.
Toxic evergreen perennial of European woodlands; historically used in minute doses as drastic purgative and for intestinal worms.
Helleborus foetidus (stinking hellebore) is a highly toxic perennial herb containing cardiac glycosides such as hellebrin and steroidal saponins. Historically employed in minute doses as a drastic purgative and anthelmintic, its use is now limited to ethnobotanical documentation and toxicological research due to severe gastrointestinal and cardiotoxic risks.
The primary active compounds, hellebrin and related bufadienolide glycosides, inhibit the Na+/K+-ATPase pump in cardiac myocytes, increasing intracellular sodium and subsequently calcium via the Na+/Ca2+ exchanger, leading to positive inotropy. Concurrently, protoanemonin and saponins cause severe mucosal irritation, resulting in violent purgation. The narrow therapeutic window and potential for fatal arrhythmias preclude any safe internal use.