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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Strophanthus hispidus
West African vine historically used as arrow poison and in modern medicine as a source of cardiac glycosides similar to digitalis for heart conditions.
Strophanthus hispidus is a West African vine historically employed as an arrow poison and later as a source of cardiac glycosides, notably ouabain and strophanthin, for managing heart failure and arrhythmias under strict medical supervision. Its potent inotropic and chronotropic effects are mediated by inhibition of the Na+/K+-ATPase pump, but its narrow therapeutic index and high toxicity preclude self-medication.
The primary active compounds, ouabain and strophanthin, bind to and inhibit the Na+/K+-ATPase pump in cardiac myocytes, leading to increased intracellular sodium and subsequent calcium influx via the Na+/Ca2+ exchanger. This elevates intracellular calcium, enhancing myocardial contractility (positive inotropy) and reducing heart rate through vagomimetic effects. Additionally, these glycosides may modulate baroreceptor sensitivity and autonomic tone, contributing to blood pressure regulation. The presence of saponins may contribute to irritant and hemolytic effects, but their role in cardiac activity is secondary.
West African vine historically used as arrow poison and in modern medicine as a source of cardiac glycosides similar to digitalis for heart conditions.
Strophanthus hispidus is a West African vine historically employed as an arrow poison and later as a source of cardiac glycosides, notably ouabain and strophanthin, for managing heart failure and arrhythmias under strict medical supervision. Its potent inotropic and chronotropic effects are mediated by inhibition of the Na+/K+-ATPase pump, but its narrow therapeutic index and high toxicity preclude self-medication.
The primary active compounds, ouabain and strophanthin, bind to and inhibit the Na+/K+-ATPase pump in cardiac myocytes, leading to increased intracellular sodium and subsequent calcium influx via the Na+/Ca2+ exchanger. This elevates intracellular calcium, enhancing myocardial contractility (positive inotropy) and reducing heart rate through vagomimetic effects. Additionally, these glycosides may modulate baroreceptor sensitivity and autonomic tone, contributing to blood pressure regulation. The presence of saponins may contribute to irritant and hemolytic effects, but their role in cardiac activity is secondary.