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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Sutherlandia frutescens (syn. Lessertia frutescens), known as 'cancer bush', is a South African medicinal plant used traditionally for cancer, diabetes, and immune support [PMID:40763763, PMID:18761068].
Contexte
Sutherlandia frutescens is a perennial shrub indigenous to the drier regions of southern Africa, including South Africa, Lesotho, southern Namibia, and southeastern Botswana [PMID:40763763, PMID:18761068, PMID:38103580].
Usages traditionnels
Traditional uses include treatment of internal cancers, diabetes, stomach complaints, indigestion, poor appetite, dysentery, colds, influenza, kidney conditions, fever, uterine troubles, liver conditions, backache, rheumatoid arthritis, urinary tract infections, stress, anxiety, dropsy, and heart failure [PMID:18761068, PMID:38139414]. It is also used as a bitter tonic ('blood purifier') and anti-stress medication ('musa-pelo') [PMID:18761068].
Composés actifs
Phytochemicals include amino acids (such as L-canavanine, L-arginine, and GABA), triterpenoids, flavonoids (including 8-methoxyvestitol and mucronulatol), sugars, fatty acids, flavonoid glycosides, cycloartenol glycosides (sutherlandiosides A-D, sutherlandins), oleanane-type saponins, D-pinitol, tannins, phlobatannins, and cardiac glycosides [PMID:36616325, PMID:40733322, PMID:39519994, PMID:22654222, PMID:18808182, PMID:29544492].
Mécanisme d'action
The plant may act by repressing Hedgehog-signaling driven genes (Gli1 and Ptch1) in prostate cancer cells [PMID:26710108]. It suppresses the production of reactive oxygen species (ROS) and nitric oxide (NO) in microglia and neurons [PMID:27155670]. In vitro, it has been shown to induce apoptosis in cervical carcinoma cells [PMID:15763378] and prevent insulin resistance in human liver cells by regulating diabetes-related genes [PMID:23376105].
Preuves cliniques
Preuve BHIV/AIDS (Safety/Efficacy)
In an adaptive double-blind RCT, S. frutescens did not change HIV viral load or CD4 T-lymphocyte count over 24 weeks [PMID:26186450].
Preuve BGeneral Health (Safety)
A randomized, double-blind, placebo-controlled pilot study in healthy adults evaluated the safety of 800 mg/day of leaf powder [PMID:17476314].
Preuve CCancer
While in vitro studies show antiproliferative and pro-apoptotic effects, a review suggests its potential as a cancer treatment remains highly questionable due to unrealistic dosages in studies [PMID:40763763, PMID:15763378].
Preuve DType 2 Diabetes
In Wistar rats, the extract normalized insulin levels and increased glucose uptake in muscle and adipose tissue [PMID:16939705].
Sécurité et effets indésirables
In vitro, the plant can be cytotoxic and pro-apoptotic [PMID:37796713]. One study in HIV-seropositive adults noted that while it did not affect viral load, the mean and total burden of certain symptoms were analyzed [PMID:26186450].
Interactions médicamenteuses
There is potential for drug-herb interactions via alterations in metabolism and transportation, specifically involving cytochrome P450 enzymes and P-glycoprotein [PMID:21756221]. It may interfere with the redox-dependent activation of isoniazid and other prodrugs used for tuberculosis [PMID:27155670].
Synthèse des preuves
Evidence is primarily based on in vitro studies and animal models (Level D) and a few small-scale clinical trials (Level B). While promising in laboratory settings for anti-inflammatory and anti-diabetic effects, clinical efficacy for cancer and HIV is not well-supported by the provided data.
Sources PubMed
1.PMID: 40763763 (2025) — The "Cancer Bush" Sutherlandia (syn. Lessertia) frutescens. An Example of Promotional Research, or Is There Scientific Merit? · Planta medica
2.PMID: 27155670 (2016) — Does Concurrent Use of Some Botanicals Interfere with Treatment of Tuberculosis? · Neuromolecular medicine
3.PMID: 36616325 (2023) — The Potential of Rhizobacteria to Mitigate Abiotic Stress in Lessertia frutescens. · Plants (Basel, Switzerland)
4.PMID: 40733322 (2025) — Phytochemistry, Ethnopharmacology, and Pharmacology of Lessertia frutescens (Cancer Bush): A Comprehensive Review. · Plants (Basel, Switzerland)
5.PMID: 37796713 (2023) — The Effect of Aqueous Lessertia frutescens Extract on TM3 Leydig Cells Exposed to TNF-α in vitro.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 39519994 (2024) — Isolation of Lessertiosides A and B and Other Metabolites from Lessertia frutescens and Their Neuroprotection Activity. · Plants (Basel, Switzerland)
7.PMID: 38103580 (2024) — Adventitious root culture of Lessertia frutescens for the production of triterpenoid saponins and polysaccharides. · Journal of biotechnology
8.PMID: 24480566 (2014) — Immunomodulating polysaccharides from Lessertia frutescens leaves: isolation, characterization and structure activity relationship. · Journal of ethnopharmacology
9.PMID: 26187042 (2015) — Sutherlandia frutescens may exacerbate HIV-associated neuroinflammation. · Journal of negative results in biomedicine
10.PMID: 33776463 (2021) — The Effect of Rooibos (Aspalathus linearis), Honeybush (Cyclopia intermedia) and Sutherlandia (Lessertia frutescens) on Testicular Insulin Signalling in Streptozotocin-Induced Diabetes in Wistar Rats. · Diabetes, metabolic syndrome and obesity : targets and therapy
11.PMID: 21756221 (2011) — Drug interactions in African herbal remedies. · Drug metabolism and drug interactions
12.PMID: 38139414 (2023) — Bioprospecting for Rhizobacteria with the Ability to Enhance Drought Tolerance in Lessertia frutescens. · International journal of molecular sciences
13.PMID: 26498493 (2015) — A review of commercially important African medicinal plants. · Journal of ethnopharmacology
14.PMID: 22654222 (2011) — Comparison of the selected secondary metabolite content present in the cancer-bush Lessertia (Sutherlandia) frutescens L. Extracts. · African journal of traditional, complementary, and alternative medicines : AJTCAM
15.PMID: 34471699 (2021) — The complete chloroplast genome of Lessertia frutescens (L.) Goldblatt & J. C. Manning (Leguminosae), an important medicinal plant species from Southern Africa. · Mitochondrial DNA. Part B, Resources
16.PMID: 15763378 (2005) — Sutherlandia frutescens extracts can induce apoptosis in cultured carcinoma cells. · Journal of ethnopharmacology
17.PMID: 23376105 (2013) — Sutherlandia frutescens prevents changes in diabetes-related gene expression in a fructose-induced insulin resistant cell model. · Journal of ethnopharmacology
18.PMID: 18761068 (2008) — A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae). · Journal of ethnopharmacology
19.PMID: 17476314 (2007) — A randomized, double-blind, placebo-controlled trial of Lessertia frutescens in healthy adults. · PLoS clinical trials
20.PMID: 15374599 (2004) — The antioxidant potential of Sutherlandia frutescens. · Journal of ethnopharmacology
21.PMID: 31365763 (2019) — Role of medicinal plants in HIV/AIDS therapy. · Clinical and experimental pharmacology & physiology
22.PMID: 29544492 (2018) — The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds. · BMC complementary and alternative medicine
23.PMID: 22579002 (2012) — Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism. · Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
24.PMID: 26585972 (2015) — Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages. · International immunopharmacology
25.PMID: 18808182 (2008) — Cycloartane glycosides from Sutherlandia frutescens. · Journal of natural products
26.PMID: 26186450 (2015) — Consumption of Sutherlandia frutescens by HIV-Seropositive South African Adults: An Adaptive Double-Blind Randomized Placebo Controlled Trial. · PloS one
27.PMID: 34220044 (2021) — Soil nutrient status of KwaZulu-Natal savanna and grassland biomes causes variation in cytokinin functional groups and their levels in above-ground and underground parts of three legumes. · Physiology and molecular biology of plants : an international journal of functional plant biology
28.PMID: 26710108 (2015) — Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. · PloS one
29.PMID: 16939705 (2007) — Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet. · Journal of ethnopharmacology
30.PMID: 27575007 (2016) — An Investigation into the Immunomodulatory Activities of Sutherlandia frutescens in Healthy Mice. · PloS one