Fiche d'information compilée à partir de PubMed
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Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Tipuana tipu is a leguminous tree indigenous to Argentina and used extensively in urban landscaping [PMID:12710729]. It is studied for its potential antioxidant, anti-inflammatory, and antidiabetic properties [PMID:38671392, PMID:42245235].
Contexte
Tipuana tipu (Benth.) Kuntze is a tree of the Fabaceae family (Papilionoideae) indigenous to Argentina and widely used in urbanism, particularly in Southern Brazil [PMID:12710729, PMID:37312011].
Usages traditionnels
Tipuana tipu is described as a leguminous plant traditionally valued for various medicinal properties [PMID:42245235].
Composés actifs
The flowers contain bioactive components analyzed via LC-MS/MS [PMID:38671392]. Leaf extracts contain flavonoids including kaempferol, quercetin, rutin, and chlorogenic acid [PMID:24144158, PMID:25169776]. Epicuticular waxes of leaves, branches, and flowers contain aliphatic alcohols, alkanes, aliphatic acids, and lupeol and b-amyrin hexadecanoates [PMID:12710729]. Essential oils from different parts of the tree contain sesquiterpene hydrocarbons (e.g., β-caryophyllene, germacrene D) in roots, and non-terpene hydrocarbons (e.g., n-tetradecane, 1,7-dimethylnaphthalene, n-octadecane) in pods, leaves, stems, and flowers [PMID:26916976]. Leaf leachates are characterized by condensed tannins and oxalic acid (cyclohexyl hexyl ester) [PMID:41480725].
Mécanisme d'action
In silico docking suggests that phytocompounds from T. tipu leaves (nonadecanol, alpinumisoflavone, β-sitosterol glucoside, protocatechualdehyde, and protocatechuic acid) may bind with carbohydrate-digesting enzymes α-amylase and α-glucosidase [PMID:42245235]. Methanol extracts of flowers have shown inhibitory activity against iNOS, NO production, and pro-inflammatory cytokines including NF-KB, TNF-R2, TNF-α, IL-1β, and IL-6 in LPS-activated RAW 264.7 macrophages [PMID:38671392].
Preuves cliniques
Preuve DHyperglycemia
Methanolic extract of T. tipu (METT) demonstrated glucose-lowering activity in streptozotocin-induced diabetic rats [PMID:42245235]
Preuve DInflammation
Leaf extracts containing acylated kaempferol glycosides showed anti-inflammatory activity in a carrageenin-induced rat paw oedema model [PMID:25169776]
Preuve DOxidative Stress
Methanol extracts of flowers exhibited antioxidant activity in DPPH, ABTS, and FRAP assays [PMID:38671392]
Sécurité et effets indésirables
Tipuana tipu pollen has been reported as a potential new allergen capable of triggering allergic symptoms [PMID:38683076].
Synthèse des preuves
The current evidence for Tipuana tipu is primarily based on in vitro assays and animal models (Level D), focusing on phytochemical profiling and preliminary pharmacological activities such as antioxidant, anti-inflammatory, and antihyperglycemic effects.
Sources PubMed
- 1.PMID: 37312011 (2023) — Predatory Arthropods Associated with the Invasive Tipu Psyllid, Platycorypha nigrivirga, in Southern Spain. · Neotropical entomology
- 2.PMID: 38671392 (2024) — LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches. · BMC complementary medicine and therapies
- 3.PMID: 38683076 (2024) — [Aerobiological study in Lima, Perú. ¿Tipuana-Tipu, perhaps a new allergen?]. · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
- 4.PMID: 42245235 (2026) — Antidiabetic effects of Tipuana tipu leaves: in silico docking and experimental study in streptozotocin-induced diabetic rats. · In silico pharmacology
- 5.PMID: 12710729 (2003) — Chemical composition of Tipuana tipu, a source for tropical honey bee products.