Gueule-de-loup (Trametes versicolor): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does turkey tail mushroom work in the body?

Turkey tail works primarily through its bioactive polysaccharides, specifically PSK and PSP. These compounds act as immunomodulators by binding to receptors on immune cells, such as T-cells and natural killer cells, to enhance their activity. This mechanism helps the body identify and eliminate infected or abnormal cells. Evidence Level B supports its role in modulating immune response and providing antioxidant protection.

Does turkey tail mushroom interact with medications?

Turkey tail has a low risk of severe drug interactions, but caution is necessary for specific groups. Because it stimulates immune function, it may counteract immunosuppressant drugs prescribed for organ transplant recipients or autoimmune diseases. While often used alongside chemotherapy in Japan, patients must consult their oncologist before use to ensure it does not interfere with specific cancer treatments.

What is the recommended dosage for turkey tail mushroom?

For adults, the standard dosage depends on the preparation. For powdered extracts, a daily intake of 1 to 3 grams is typical. If using the dried mushroom for a decoction or tea, 2 to 9 grams daily is recommended. Consistency is important for immune support. Always adhere to product labels or seek guidance from a medical herbalist for condition-specific dosing.

Is turkey tail safe to take during pregnancy?

Turkey tail is considered unsafe during pregnancy and breastfeeding. There is insufficient safety data regarding the effects of its potent immune-modulating polysaccharides on the developing fetus or nursing infant. Consequently, pregnant women are advised to avoid turkey tail supplements. Always consult a qualified healthcare provider before starting any new herbal regimen while pregnant.

What are the main side effects of turkey tail?

Turkey tail is generally well-tolerated, but some users experience mild gastrointestinal symptoms. Common side effects include gas, bloating, and stomach upset. Users may also notice harmless darkening of the stool or nail pigmentation. Those with autoimmune conditions should avoid this herb, as stimulating the immune system could worsen their condition.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 28 articles PubMed · modèle : gemma4:31b

Résumé

Turkey Tail (Trametes versicolor) is a medicinal mushroom used as a functional food and adjuvant therapy in cancer treatment due to its immunomodulatory and anticancer properties [PMID:37513265, PMID:32466253].

Contexte

Trametes versicolor (also known as Coriolus versicolor) is a higher fungi/mushroom in the Polyporaceae family [PMID:32466253]. It is characterized as a white-rot fungus [PMID:33752945, PMID:14499133].

Usages traditionnels

It has been used in traditional Chinese medicine for over 2000 years to regulate immunity and prevent cancer [PMID:36827712, PMID:36359361, PMID:31030754, PMID:36902290].

Composés actifs

Bioactive components include (1,3)(1,6)-β-D-glucans, triterpenes, phenolic compounds, sterols [PMID:37513265], and polysaccharopeptides such as Polysaccharide Peptide (PSP) and Polysaccharide-K (PSK/Krestin) [PMID:32466253, PMID:36902290, PMID:31030754]. It also contains the enzyme laccase [PMID:36978275, PMID:41150756].

Mécanisme d'action

The mushroom exhibits immunomodulatory effects by inducing a pro-inflammatory cytokine profile and affecting various immune subsets [PMID:28932226]. Specifically, β-glucans induce the expression of Dectin-1, costimulatory molecules (CD80/86), and cytokines IL-6, IL-1β, IFN-β, and IL-10 [PMID:35215831]. In cancer cells, it can induce apoptotic cell death, poly (ADP-ribose) polymerase cleavage, and upregulate autophagy-associated marker LC3-II [PMID:36827712].

Preuves cliniques

Preuve CCancer (General/Adjuvant)

Polysaccharides (PSP and PSK) are used as adjuvant therapy to improve survival and quality of life in cancer patients [PMID:32466253, PMID:31030754].

Preuve BBreast Cancer

Findings demonstrate antiproliferative, pro-apoptotic, and immunomodulatory effects; one phase I trial reported good tolerability [PMID:41150756, PMID:19087769].

Preuve ALung Cancer

Systematic review of PSK for lung cancer included 6 RCTs and 5 nonrandomized trials, with 15 of 17 preclinical studies supporting anticancer effects [PMID:25784670].

Preuve CColorectal Cancer

Extracts show strong cell growth inhibitory activity on human colorectal tumor cells [PMID:36359361].

Preuve DHuman Papillomavirus (HPV)

A retrospective cohort study found HPV clearance was significantly higher in a group treated with a Coriolus versicolor-based vaginal gel (89.3% vs 44.7%) [PMID:42187868].

Preuve D

Sécurité et effets indésirables

A toxicological assessment in rats evaluating whole mushroom powders (mycelial biomass and primordia) was conducted to assess acute, subchronic, and genotoxicity [PMID:41230556]. One phase I clinical trial in breast cancer patients reported good tolerability [PMID:41150756].

Synthèse des preuves

Evidence ranges from in vitro studies (D) and reviews (C) to systematic reviews (A) and clinical trials (B), with the strongest evidence supporting its use as an immunomodulatory adjuvant in cancer therapy, particularly lung and breast cancers.

Sources PubMed

1.PMID: 37513265 (2023) — Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. · Molecules (Basel, Switzerland)
2.PMID: 32466253 (2020) — Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy. · Biomedicines
3.PMID: 28267306 (2002) — Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. · Recent patents on inflammation & allergy drug discovery
4.PMID: 27929633 (2002) — Trametes versicolor carboxylate reductase uncovered. · Monatshefte fur chemie
5.PMID: 36827712 (2023) — The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro.

Gueule-de-loup

Sources et citations

Calculer une dose sûre de Gueule-de-loup

Chaga

Andrographis

Maitake

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Gueule-de-loup

Sources et citations

Calculer une dose sûre de Gueule-de-loup

Plantes associées

Chaga

Andrographis

Maitake

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales