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VO
Not CommonRésumée par IA
Viola Odorata Herb
Viola odorata
remède contre le mucus respiratoire en médecine populaire européenne
Viola odorata contains mucilage compounds that form a soothing protective layer over mucous membranes in the respiratory tract. This demulcent action helps reduce irritation and inflammation while loosening thick mucus, making it easier to expel. The herb also contains salicylates which provide mild anti-inflammatory effects. Traditional use and pharmacopological studies support these expectorant properties, though clinical evidence remains limited (Evidence Level C).
Does sweet violet interact with blood thinners or other medications?
Viola odorata contains natural salicylates, which may theoretically interact with anticoagulant medications like warfarin and antiplatelet drugs such as aspirin or clopidogrel. Individuals taking blood-thinning medications should consult a healthcare provider before use. Due to its mild sedative properties, sweet violet may also enhance the effects of CNS depressants including benzodiazepines and sleep medications. No clinical drug interaction studies have been conducted (Evidence Level C).
What is the recommended dosage for Viola odorata tea?
The standard adult dosage for Viola odorata is 2-4 grams of dried leaves and flowers prepared as a hot infusion (tea), taken up to three times daily for respiratory conditions. For skin inflammation, a cooled infusion or poultice can be applied topically. Start with the lower dose to assess individual tolerance. These recommendations are based on traditional use and pharmacopoeial standards rather than clinical trials (Evidence Level C).
Is Viola odorata safe to take during pregnancy?
Viola odorata is considered unsafe during pregnancy and should be avoided. The herb contains salicylates and other compounds that may stimulate uterine contractions or affect fetal development, particularly at therapeutic doses. Traditional contraindications specifically warn against use during pregnancy. Women who are pregnant, breastfeeding, or attempting to conceive should not use sweet violet preparations without guidance from a qualified healthcare practitioner.
What is sweet violet used for in herbal medicine?
Viola odorata has been used in European and Unani traditional medicine primarily as a respiratory remedy. It acts as an expectorant and demulcent to soothe coughs, bronchitis, and sore throats. Additional traditional applications include treating headaches, insomnia, and skin inflammation due to its mild anti-inflammatory and sedative properties. While these uses are well-established in folk medicine, scientific evidence supporting them remains limited (Evidence Level C).
Who should not take Viola odorata?
Viola odorata is contraindicated for pregnant women, particularly at higher doses. Individuals with salicylate sensitivity or allergy to aspirin should avoid this herb due to its natural salicylate content. Those taking anticoagulant or antiplatelet medications should consult a healthcare provider before use. People with known allergies to plants in the Violaceae family should exercise caution. Rare gastrointestinal upset may occur in sensitive individuals.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Viola odorata, also known as sweet violet or English violet, is a perennially herbaceous plant found in Europe and Asia with various medicinal applications [PMID:37694059].
Contexte
Viola odorata is a tough, perennially herbaceous flowering plant native to Europe and Asia [PMID:37694059].
Usages traditionnels
In traditional Persian medicine, it is used to manage cough, fever, common cold, headache, insomnia, epilepsy, constipation, palpitation, dyspnea, dysuria, and skin diseases [PMID:28948657]. It is also traditionally used for the treatment of diabetes [PMID:33490239] and neuropsychiatric disorders [PMID:29775777].
Composés actifs
Phytochemical constituents include coumarins (such as umbelliferone and esculetin), caffeic acid, methyl salicylate, flavonoids (quercetin, kaempferol), glycosides (rutin), and terpenoids (stigma sterol) [PMID:37694059]. It also contains procyanidins (specifically procyanidin C1) [PMID:35487935], anthocyanins [PMID:35591648], and cyclic peptides known as cyclotides (e.g., cycloviolacin O1, cycloviolacin O2, and vodo-C1) as well as acyclotides (e.g., violacin A) [PMID:31812106, PMID:37099442, PMID:36107799, PMID:38679329].
Mécanisme d'action
Procyanidin C1 from V. odorata inhibits Na+,K+-ATPase [PMID:35487935]. Certain flavonoid derivatives may involve a serotonergic mechanism for antidepressant-like effects [PMID:29775777]. The plant's extracts have demonstrated the ability to reduce intracellular reactive oxygen species (ROS) and inhibit cellular tyrosinase [PMID:27516984, PMID:28392894]. Additionally, the cyclotide vodo-C1 has been identified as a ligand for the cannabinoid type 2 receptor (CB2R) [PMID:38679329].
Preuves cliniques
Preuve AInsomnia
A systematic review and meta-analysis of five clinical trials (224 patients) showed significant improvement in total PSQI scores, subjective sleep quality, and sleep duration compared to placebo [PMID:35734476].
Preuve BChronic Insomnia
Intranasal drops of violet oil significantly improved sleep and Insomnia Severity Index (ISI) scores over one month [PMID:25763239].
Preuve BFever in children
Topical application of viola oil (20 drops) to the umbilicus significantly reduced mean axillary temperature after 30 minutes compared to placebo [PMID:31250761].
Preuve BCOVID-19
A randomized double-blind controlled trial evaluated the efficacy of sweet violet syrup in alleviating manifestations of COVID-19 infection [PMID:36535329].
Preuve BInsomnia in patients with depression or OCD
A pilot randomized double-blind placebo-controlled trial investigated the use of V. odorata syrup as an add-on therapy for sleep quality [PMID:32073874].
Preuve B
Sécurité et effets indésirables
V. odorata oil was reported as safe for fever control in febrile neutropenic children [PMID:31250761]. In B16F10 murine melanoma cells, the extract showed no cytotoxicity [PMID:28392894].
Synthèse des preuves
Evidence ranges from high-level systematic reviews for insomnia (Level A) and several randomized controlled trials for fever and sleep (Level B), to in vitro and animal studies regarding antioxidant, anti-cancer, and antimicrobial properties (Level D).
Sources PubMed
1.PMID: 37694059 (2023) — Detection of Coumarin Derivatives of Viola odorata Cultivated in Iraq. · Journal of pharmacy & bioallied sciences
2.PMID: 35487935 (2022) — Procyanidin C1 from Viola odorata L. inhibits Na+,K+-ATPase. · Scientific reports
3.PMID: 36838663 (2023) — Commercially Available Viola odorata Oil, Chemical Variability and Antimicrobial Activity. · Molecules (Basel, Switzerland)
4.PMID: 35734476 (2022) — The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis. · Frontiers in neurology
5.PMID: 31812106 (2020) — An overview of acyclotides: Past, present and future. · Phytochemistry
6.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
A randomized triple-blind controlled trial assessed the effects of V. odorata syrup (5ml twice daily) on sleep quality [PMID:38177831].
PMID: 37099442 (2023) — Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans. · Journal of natural products
7.PMID: 35115562 (2022) — The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite. · Scientific reports
8.PMID: 41960579 (2026) — The genome sequence of the sweet violet, Viola odorata L. (Malpighiales: Violaceae). · Wellcome open research
9.PMID: 28948657 (2017) — A Critical Review on Phytochemistry, Pharmacology of Viola odorata L. and Related Multipotential Products in Traditional Persian Medicine. · Phytotherapy research : PTR
10.PMID: 27516984 (2016) — Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species. · Avicenna journal of phytomedicine
11.PMID: 34981485 (2021) — Role of Herbal Medicines in the Management of Brain Injury. · Advances in experimental medicine and biology
12.PMID: 38628881 (2023) — Herbal Treatment of COPD and Asthma According to Persian Medicine: a Review of Current Evidence. · Tanaffos
13.PMID: 36107799 (2023) — Cyclic cystine knot and its strong implication on the structure and dynamics of cyclotides. · Proteins
14.PMID: 35591648 (2022) — Impact of Drying Conditions on Antioxidant Activity of Red Clover (Trifolium pratense), Sweet Violet (Viola odorata) and Elderberry Flowers (Sambucus nigra). · Materials (Basel, Switzerland)
15.PMID: 35490427 (2022) — Native Iranian Medicinal Plants with Anti-Vaginal Infection Properties: A Systematic Review. · Infectious disorders drug targets
16.PMID: 25763239 (2014) — Efficacy of Viola odorata in Treatment of Chronic Insomnia. · Iranian Red Crescent medical journal
17.PMID: 35292687 (2022) — Larvicidal and adulticidal effects of some Egyptian oils against Culex pipiens. · Scientific reports
18.PMID: 33490239 (2020) — In Silico Prediction of the Mode of Action of Viola odorata in Diabetes. · BioMed research international
19.PMID: 36535329 (2023) — Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: A randomized double-blind controlled trial. · Journal of ethnopharmacology
20.PMID: 38177831 (2024) — Effects of Viola odorata syrup on sleep quality in menopausal women: a randomized, triple-blind, controlled trial. · Sleep & breathing = Schlaf & Atmung
21.PMID: 29775777 (2018) — Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): Pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism. · Fitoterapia
22.PMID: 30292877 (2018) — Production of bioactive cyclotides in somatic embryos of Viola odorata. · Phytochemistry
23.PMID: 28392894 (2017) — Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells. · Iranian journal of basic medical sciences
24.PMID: 20564007 (2010) — A new "era" for cyclotide sequencing. · Biopolymers
25.PMID: 32073874 (2020) — Effects of Viola odorata as an Add-On Therapy on Insomnia in Patients with Obsession or Depression: A Pilot Randomized Double-Blind Placebo-Controlled Trial. · Journal of alternative and complementary medicine (New York, N.Y.)
26.PMID: 32056127 (2020) — Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells. · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
27.PMID: 32507426 (2020) — Efficacy of Sweet Violet (Viola odorata) flower oil on the symptoms of adults with allergic rhinitis: A double-blind randomized placebo-controlled clinical trial. · Complementary therapies in medicine
28.PMID: 31250761 (2020) — The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial. · Current drug discovery technologies
29.PMID: 30387611 (2018) — Discovery and Characterization of Cyclotides from Rinorea Species. · Journal of natural products
30.PMID: 38679329 (2024) — Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor. · The Journal of biological chemistry