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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Asarum canadense
Low-growing woodland perennial with distinctive kidney-shaped leaves and ginger-like rhizome; used by Indigenous peoples as condiment and medicine.
Wild Ginger (Asarum canadense) is a low-growing woodland perennial historically used by Indigenous peoples as a condiment and digestive tonic. Its primary active compounds include aristolochic acid, methyleugenol, and asarone, which contribute to both its traditional carminative effects and its well-documented nephrotoxic and carcinogenic risks. Due to the presence of aristolochic acid, medicinal use is not recommended, and only small culinary amounts are considered safe.
Aristolochic acid, a major constituent, undergoes metabolic activation by N-hydroxylation via cytochrome P450 (CYP1A1/2) to form DNA adducts, leading to nephrotoxicity and carcinogenicity through p53 mutation and renal tubular injury. Methyleugenol and asarone exhibit weak GABAergic modulation and anti-inflammatory activity via COX-2 inhibition, but these effects are overshadowed by toxicity. The phenylpropanoids and terpenes contribute to mild carminative and spasmolytic actions through smooth muscle relaxation, likely via calcium channel blockade.
Low-growing woodland perennial with distinctive kidney-shaped leaves and ginger-like rhizome; used by Indigenous peoples as condiment and medicine.
Wild Ginger (Asarum canadense) is a low-growing woodland perennial historically used by Indigenous peoples as a condiment and digestive tonic. Its primary active compounds include aristolochic acid, methyleugenol, and asarone, which contribute to both its traditional carminative effects and its well-documented nephrotoxic and carcinogenic risks. Due to the presence of aristolochic acid, medicinal use is not recommended, and only small culinary amounts are considered safe.
Aristolochic acid, a major constituent, undergoes metabolic activation by N-hydroxylation via cytochrome P450 (CYP1A1/2) to form DNA adducts, leading to nephrotoxicity and carcinogenicity through p53 mutation and renal tubular injury. Methyleugenol and asarone exhibit weak GABAergic modulation and anti-inflammatory activity via COX-2 inhibition, but these effects are overshadowed by toxicity. The phenylpropanoids and terpenes contribute to mild carminative and spasmolytic actions through smooth muscle relaxation, likely via calcium channel blockade.