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Withania coagulans
Relative of ashwagandha used in Ayurveda and Unani medicine for diabetes, and as vegetarian milk coagulant for cheese.
Withania coagulans, a close relative of ashwagandha, is used in Ayurveda and Unani medicine primarily for its antidiabetic, hepatoprotective, and anti-inflammatory properties, as well as a traditional milk coagulant. Its key active compounds include withanolides (e.g., withacoagin), diosgenin, and tropane alkaloids, which contribute to its diverse pharmacological actions.
The antidiabetic effects of Withania coagulans are mediated through activation of PPAR-γ, enhancement of insulin sensitivity, and inhibition of α-glucosidase, leading to reduced postprandial hyperglycemia. Its withanolides also inhibit NF-κB signaling, providing anti-inflammatory and hepatoprotective benefits. Additionally, the herb may modulate thyroid function by influencing T3 and T4 levels, though the exact receptor pathways remain under investigation.
Relative of ashwagandha used in Ayurveda and Unani medicine for diabetes, and as vegetarian milk coagulant for cheese.
Withania coagulans, a close relative of ashwagandha, is used in Ayurveda and Unani medicine primarily for its antidiabetic, hepatoprotective, and anti-inflammatory properties, as well as a traditional milk coagulant. Its key active compounds include withanolides (e.g., withacoagin), diosgenin, and tropane alkaloids, which contribute to its diverse pharmacological actions.
The antidiabetic effects of Withania coagulans are mediated through activation of PPAR-γ, enhancement of insulin sensitivity, and inhibition of α-glucosidase, leading to reduced postprandial hyperglycemia. Its withanolides also inhibit NF-κB signaling, providing anti-inflammatory and hepatoprotective benefits. Additionally, the herb may modulate thyroid function by influencing T3 and T4 levels, though the exact receptor pathways remain under investigation.