PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Ethyl acetate extracts showed in vitro activity against chloroquine-sensitive and chloroquine-resistant strains; a novel diarylheptanoid inhibited parasite growth by 69%-74% in vitro [PMID:18996179, PMID:32713200]
Siphonochilone exhibited significant cytotoxic effects on pancreatic, breast, lung, colon, and liver cancer cell lines (IC50 22-124 μM) [PMID:38742918]. However, a new siphonochilone derivative showed poor antitumor effect [PMID:38585140].
Ethanolic extracts exhibited high inhibitory activity against cyclooxygenase (COX) in vitro [PMID:10075117]
A diarylheptanoid demonstrated anti-leishmanial activity via a Th1-mediated pro-inflammatory response and inhibition of LdTopoII [PMID:37199276]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 34011227 (2022) — A new sesquiterpene from South African wild ginger (Siphonochilus aethiopicus (Schweinf) B.L. Burtt). · Natural product research
- 2.PMID: 33039627 (2021) — Ethnomedicinal uses, biological activities, phytochemistry and conservation of African ginger (Siphonochilus aethiopicus): A commercially important and endangered medicinal plant. · Journal of ethnopharmacology
- 3.PMID: 23983325 (2012) — Bioactive diterpenes and sesquiterpenes from the rhizomes of wild ginger (Siphonochilus aethiopicus (Schweinf) B.L Burtt). · African journal of traditional, complementary, and alternative medicines : AJTCAM
- 4.PMID: 32713200 (2021) — Antiplasmodial activity of a novel diarylheptanoid from Siphonochilus aethiopicus. · Natural product research
- 5.PMID: 11830157