PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Agnimanthadi compound (containing Agnimantha, Mustaka, Gomutra, and Eranda Patra Kshara) was studied for weight management, though the provided abstract notes that generalized steaming (Vashpa Svedana) provided marked reduction in weight [PMID:24696576]. Another study using Shilajatu processed with Agnimantha (identified as Clerodendrum phlomidis) showed a statistically significant reduction in body weight (5.09 ± 0.24 kg) and BMI (2.06 ± 0.10 kg/m2) [PMID:22661848].
Hydroalcoholic extract (HAE) of P. integrifolia root bark demonstrated significant dose-dependent anti-atherosclerotic activity in high fat diet induced rats, reducing lipids and lipoproteins [PMID:29404027].
Topical application of P. integrifolia extract (5% W/W ointment) in rats accelerated the wound healing process [PMID:35463068].
Root extracts showed potent inhibition of COX-2 and 5-LOX in enzyme-based assays [PMID:30339925].
Safety & adverse effects
Dosage & administration
Evidence summary
PubMed sources
- 1.PMID: 27143797 (2016) — Pharmacological potentials of Premna integrifolia L. · Ancient science of life
- 2.PMID: 26600661 (2015) — Premna integrifolia L.: A review of its biodiversity, traditional uses and phytochemistry. · Ancient science of life
- 3.PMID: 23723639 (2012) — A critical review on two types of Laghupanchamula. · Ayu
- 4.PMID: 28486830 (2017) — Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: a review. · Pharmaceutical biology
- 5.PMID: 30339925 (2018) — Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor.