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Compiled from 25 PubMed articles · model: gemma4:31b
Summary
Alpinia calcarata is a rhizomatous perennial herb used in traditional Sri Lankan medicine, demonstrating experimental antibacterial, anti-inflammatory, and antidiabetic activities [PMID:26009694].
Background
Alpinia calcarata Roscoe (Family: Zingiberaceae), also known as lesser galangal, is a rhizomatous perennial herb cultivated in tropical regions including Sri Lanka, India, Malaysia, China, Bangladesh, Indonesia, and Thailand [PMID:26009694, PMID:37715949].
Traditional uses
In traditional practices, the rhizomes are used to treat diabetes, rheumatism, gastrointestinal problems, inflammatory diseases, cough, respiratory problems, bronchitis, asthma, and arthritis [PMID:35026343, PMID:22209884].
Active compounds
Phytochemical screening has identified polyphenols, tannins, flavonoids, steroid glycosides, and alkaloids [PMID:26009694, PMID:21589752]. Specific compounds include galangin [PMID:35026343], stigmasterol [PMID:39520721], labdane-type diterpenoids (such as calcaratarins A-E) [PMID:12357393, PMID:10924169], and essential oil components including 1,8-cineole, alpha-terpineol, camphor, eucalyptol, and carotol [PMID:37715949, PMID:32419793].
Mechanism of action
Galangin from the rhizomes inhibits IRAK-1/MAPK/NF-κB p65 and JAK-1 signaling in LPS-stimulated cells [PMID:35026343]. The herb's anti-inflammatory effects are mediated through membrane stabilizing, antihistamine, and prostaglandin synthesis inhibition activities [PMID:22209884], as well as the modulation of COX-2 and PPAR-γ in obese models [PMID:39897811]. Antinociceptive effects are mediated via opioid mechanisms [PMID:15507354]. Calcaratarin D attenuates asthma by modulating alveolar macrophage function and suppressing Arg1 (M2 macrophage marker) [PMID:36440573].
Clinical evidence
Evidence DDiabetes
Ethanolic extract (200 mg/kg) brought altered biochemical profiles in streptozotocin-induced diabetic rats back to near normal [PMID:24502532].
Evidence DInflammation/Edema
Hot water and ethanolic extracts showed anti-inflammatory activity in carrageenan-induced paw edema models in rats [PMID:22209884]. Essential oils reduced TPA-induced skin inflammation in mice [PMID:32419793].
Evidence DPain (Nociception)
Aqueous and ethanolic extracts showed dose-dependent antinociceptive activity in hot plate and formalin tests in rats [PMID:15507354].
Evidence DAsthma
Calcaratarin D reduced serum IgE levels, mucus hypersecretion, and airway hyperresponsiveness in house dust mite-induced asthma mouse models [PMID:36440573].
Evidence DObesity
Methanol leaf extract (200mg/kg) decreased adiposity and adipocyte inflammation in high-fat diet-induced obese mice [PMID:39897811].
Evidence D
Safety & adverse effects
In a study on Ehrlich's ascitic carcinoma, host toxic effects were reported as not very high and recovered gradually within a few days after treatment [PMID:22221755].
Evidence summary
The current evidence is based entirely on in vitro studies and animal models (rats and mice), representing a low overall strength of clinical evidence (Level D).
PubMed sources
1.PMID: 26009694 (2015) — Alpinia calcarata Roscoe: A potential phytopharmacological source of natural medicine. · Pharmacognosy reviews
2.PMID: 35026343 (2022) — Identification of galangin as the bioactive compound from Alpinia calcarata (Haw.) Roscoe rhizomes to inhibit IRAK-1/ MAPK/ NF-κB p65 and JAK-1 signaling in LPS stimulated RAW 264.7 cells. · Journal of ethnopharmacology
3.PMID: 24502532 (2014) — Effect of Alpinia calcarata on glucose uptake in diabetic rats-an in vitro and in vivo model. · Journal of diabetes and metabolic disorders
4.PMID: 22209884 (2012) — Alpinia calcarata Roscoe: a potent antiinflammatory agent. · Journal of ethnopharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Ethanolic rhizome extract (250 and 500 mg/kg) attenuated neurotoxicity and improved mechanical allodynia and thermal hyperalgesia in cisplatin-induced neuropathic rats [PMID:39520721].
Evidence DCancer (Ehrlich's Ascitic Carcinoma)
Ethanol extract (8 mg/kg/day i.p.) significantly decreased tumor weight and increased life span in mice [PMID:22221755].
— Investigation of Alpinia calcarata constituent interactions with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and network approach.
· Journal of molecular modeling
6.PMID: 37715949 (2024) — Antioxidant, Diabetic and Inflammatory Activities of Alpinia calcarata Roscoe Extract. · Chemistry & biodiversity
7.PMID: 12357393 (2002) — New cytotoxic bis-labdanic diterpenoids from Alpinia calcarata. · Planta medica
8.PMID: 21589752 (2010) — Standardization of Alpinia calcarata Roscoe rhizomes. · Pharmacognosy research
9.PMID: 23723656 (2012) — Comparative powder microscopy of Alpinia calcarata Roscoe and Alpinia galanga (Linn.) Willd. · Ayu
10.PMID: 39897811 (2025) — Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ. · Heliyon
11.PMID: 36082338 (2022) — Green route synthesis of alpinia calcarata functionalized gold nanoparticles for nonlinear optical applications. · Heliyon
12.PMID: 15507354 (2004) — Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats. · Journal of ethnopharmacology
13.PMID: 36440573 (2023) — Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function. · British journal of pharmacology
14.PMID: 10924169 (2000) — Diterpenoids from the rhizomes of Alpinia calcarata. · Journal of natural products
15.PMID: 41321768 (2026) — Biogenic synthesis of copper oxide nanoparticles using Alpinia calcarata extract promotes osteoblasts differentiation: An In vitro study. · Journal of oral biology and craniofacial research
16.PMID: 21547048 (2010) — Antioxidant and antifungal activities of essential oil of Alpinia calcarata Roscoe rhizomes. · Journal of Ayurveda and integrative medicine
17.PMID: 24031946 (2012) — Amylase production by endophytic fungi Cylindrocephalumsp. isolated from medicinal plant Alpinia calcarata (Haw.) Roscoe. · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
18.PMID: 30519797 (2018) — Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles. · Nano convergence
19.PMID: 22221755 (2012) — Preventive effect of ethanol extract of Alpinia calcarata Rosc on Ehrlich's ascitic carcinoma cell induced malignant ascites in mice. · Asian Pacific journal of tropical medicine
20.PMID: 21637618 (2010) — Unusual intron in the second exon of a Type III polyketide synthase gene of Alpinia calcarata Rosc. · Genetics and molecular biology
21.PMID: 39520721 (2026) — Neuroprotective potential of Alpinia calcarata and HPLC analysis of stigmasterol against cisplatin-induced neuropathy in rat model. · Natural product research
22.PMID: 30191170 (2018) — Data on the inhibitory effect of traditional plants from Sri Lanka against tyrosinase and collagenase. · Data in brief
23.PMID: 32419793 (2020) — Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. · Evidence-based complementary and alternative medicine : eCAM
24.PMID: 16646522 (2006) — Effects of aqueous extract of Alpinia calcarata rhizomes on reproductive competence of male rats. · Acta biologica Hungarica
25.PMID: 20730971 (2010) — Chemical diversity in the genus Alpinia (Zingiberaceae): comparative composition of four Alpinia species grown in Northern India. · Chemistry & biodiversity