PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Methanol extracts (starting at 25mg/kg) showed anxiolytic activity in mice using the elevated plus-maze test [PMID:18539420].
Aqueous extracts and flavonoid fractions (containing rutin and isoquercitrin) produced dose-dependent antihyperalgesic and antiallodynic effects in rat models of fibromyalgia [PMID:36295818].
Non-polar and polar extracts increased survival rates, improved neurological deficits, and diminished infarct area in mice [PMID:26592749].
Methanol and ethyl acetate extracts significantly decreased the severity of seizures and increased latency to seizure in kainic acid-induced models in rats [PMID:36060909].
Methanolic extracts of Tilia americana showed hypoglycemic activity in alloxan-induced diabetic Wistar rats [PMID:31179342].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 12027081 (2002) — American linden, Tilia americana. · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- 2.PMID: 37039741 (2023) — Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020. · Phytotherapy research : PTR
- 3.PMID: 24234018 (1995) — Ethylene emission by a deciduous tree,Tilia americana, in response to feeding by introduced basswood thrips,Thrips calcaratus. · Journal of chemical ecology
- 4.PMID: 36864680 (2023) — Biochar mitigates allelopathic effects in temperate trees. · Ecological applications : a publication of the Ecological Society of America
- 5.PMID: 26240301